A5021039155- Neuroscience and Neuropharmacology Research
- Pharmacological Receptor Mechanisms and Effects
- Neuroinflammation and Neurodegeneration Mechanisms
- Computational Drug Discovery Methods
- Amino Acid Enzymes and Metabolism
- CRISPR and Genetic Engineering
- Ion channel regulation and function
- Retinal Development and Disorders
- Epilepsy research and treatment
- Cholinesterase and Neurodegenerative Diseases
- Plant nutrient uptake and metabolism
- Fungal and yeast genetics research
- Plant tissue culture and regeneration
- Microtubule and mitosis dynamics
- Receptor Mechanisms and Signaling
- Transgenic Plants and Applications
- Tryptophan and brain disorders
University of Ottawa
2016-2021
Ottawa Hospital
2016
Washington University in St. Louis
2006-2010
International Potato Center
2006
The sigma-1 receptor (<i>σ</i>-1R) is an endoplasmic reticulum resident chaperone protein involved in a plethora of cellular functions, and whose disruption has been implicated wide range diseases. Genetic analysis revealed two <i>σ</i>-1R mutants neuromuscular disorders. A point mutation (E102Q) the ligand-binding domain results juvenile form amyotrophic lateral sclerosis (ALS16), 20 amino-acid deletion (Δ31–50) putative cytosolic leads to distal hereditary motor neuropathy. We investigated...
How dividing cells monitor the effective transmission of genomes during mitosis is poorly understood. Budding yeast use a signaling pathway known as spindle position checkpoint (SPC) to ensure arrival one end mitotic in nascent daughter cell. An important question how SPC activity coordinated with mother–daughter polarity. We sought identify factors at bud neck, junction between mother and bud, which contribute signaling. In this paper, we show that protein kinase Elm1 an obligate regulator...
Ischemic stroke is the second leading cause of death worldwide. Following an ischemic event, neuronal triggered by uncontrolled glutamate release to overactivation sensitive N-methyl-d-aspartate receptor (NMDAR). For gating, NMDARs require not only binding glutamate, but also glycine or a glycine-like compound as co-agonist. Low doses enhance NMDAR function, whereas high trigger glycine-induced internalization (GINI) in vitro. Here, we report that following vivo, GINI occurs and provides...
Abstract Background One evident hallmark of Alzheimer's Disease (AD) is the irregular accumulation proteins such as Aβ and pTau. This could alleviate ER stress trigger an integrated signaling cascade called unfolded protein response (UPR). UPR reduces number misfolded further inhibits abnormal accumulation. Targeting may therefore be effective treatment for AD. interest that plays a role in modulating Sigma‐1 receptor (Sig1R). Sig1R agonists have been shown to neuroprotective anti‐amnesic AD...
Abstract Glycine fulfills several roles in biology including protein synthesis, inhibitory transmission via glycine receptor activation and excitatory through glutamate-sensitive N-methyl-D-aspartate receptors (NMDARs). Low doses enhance NMDAR function while high trigger glycine-induced internalization (GINI) vitro. The physiological relevance of GINI has been questioned given that the high-affinity transporter type 1 (GlyT1), located on astrocytes neurons, maintains synaptic concentrations...
Abstract Ischemic stroke is the second leading cause of death worldwide. Compelling evidence demonstrates that following an ischemic event, neuronal triggered by uncontrolled glutamate release to overactivation sensitive N-methyl-D-aspartate receptor (NMDAR). For gating, NMDARs require not only binding glutamate, but also glycine or a glycine-like compound as co-agonist. Glycine fulfills several roles in biology including protein synthesis, inhibitory transmission via activation and...