The distant metastasis is the primary cause of cancer morbidity and mortality for bladder (BLCA) paitents. All recommended therapy it largely depends on how far has invaded. It been confirmed that epithelial to mesenchymal transition (EMT) leading reason BLCA which makes difficult cure. aim present study identify BLCA-related genes can be used as new prognostic biomarker treatment target, investigate functional mechanisms TEAD4 in EMT dysregulation.The "limma" R package was differentially...

An output-capacitorless low-dropout regulator (OCL-LDO) with simple structure and fast transient response is proposed for system-on-chip (SoC) applications. A super source follower inserted into a cascoded flipped voltage to drive the power transistor, which forms fast-local loop quick turn-on. robust overshoot detection circuit consuming only leakage current turn-off. The combination of these two techniques significantly reduce overshoot/undershoot voltages achieve settling time during load...

Scutellarin inhibits hypoxia-induced and moderately high glucose–induced proliferation vascular endothelial growth factor (VEGF) expression in human retinal cells (HRECs); thus, it could be a potential therapy for diabetic retinopathy. However, how scutellarin VEGF is unknown. In our study, HRECs were treated with glucose and/or hypoxia-mimetic agent cobalt chloride to stimulate cell proliferation, migration, angiogenesis, the effects of on these processes analyzed through viability assay,...

A general approach based on a natural basis function expansion to cancel the temperature-curvature of base-emitter voltage in bipolar transistors embedded bandgap references is presented. The proposed method can be applied widely used Banba, Kuijk, and Brokaw structures build with sub-ppm/°C temperature coefficients. Current version embodiments self-bootstrapping concept are provided. Error sources that potentially affect reference performance analyzed their effects coefficient minimized...

A fully integrated low-dropout regulator (LDO) with ultra-fast transient settling is proposed to provide a clean supply for digital circuits in nano-scale technology. super source follower (SSF) inserted into the cascode flipped voltage (FVF) topology drive power transistor fast turn-on. The positive detection (PTD) circuit NMOS pull-down. combined effects of these two techniques significantly attenuate load induced spikes. LDO designed 130 nm CMOS process and consumes 100 μA quiescent...

Resistor string is one of the classic digital-to-analog converter (DAC) architectures and has dominant applications where guaranteed monotonicity important. For high-resolution DACs, gradient errors limit linearity performance by causing mismatch in resistor arrays. In this paper, a low-cost practical DAC structure with error suppression proposed. It achieves high dividing into multiple smaller substrings placing them pattern up to 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML"...

Recent studies have revealed the role of actin dynamics in regulation yeast aging. Although target rapamycin (TOR) complex, serine/threonine kinase Sch9, and Ras2 been shown to play important roles aging for a long time, relationship between these regulators has not yet reported. In this study we investigated polarization tor1Δ, sch9Δ, ras2Δ mutant cells. We found that structures cells were more dynamic than those wild type. Destruction with jasplakinolide decreased life span mutants....

This paper proposes a 77GHz millimeter wave radar-based rear occupant detection system in vehicle. The major focus is detecting forgotten children vehicle's seats. radar TX chirp signal configuration selected to detect slight movements of people (like breathing). RX IF processed through 2D-FFT build two-dimension heat map. Then, the Constant False Alarm Detection (CFAR) algorithm used for object and 2D cloud points image obtained which can visualize presence Moreover, simulated vehicle...

This paper presents a general approach to extract V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">GO</sub> from the base emitter voltage of bipolar transistor. is silicon bandgap at zero Kelvin and it physical constant independent temperature. The proposed method can be implemented on any widely used Banba, Kuijk, Brokaw or resistorless structures build references with sub-ppm/°C temperature coefficient. One embodiment based Kuijk structure...

Abstract Objective To determine the critical roles of PU.1/cathepsin S activation in regulating inflammatory responses macrophages during periodontitis. Background Cathepsin (CatS) is a cysteine protease and exerts important immune response. Elevated CatS has been found gingival tissues periodontitis patients involved alveolar bone destruction. However, underlying mechanism CatS‐driven IL‐6 production remains unclear. Methods Western blot was applied to measure mature cathepsin S(mCatS)...

As one of the important vital features human body, acquisition a speech signal plays an role in human–computer interaction. In this study, voice sounds are gathered and identified using Doppler radar. The skin on neck vibrates when person speaks, which causes vocal cords to vibrate as well. vibration received by radar will produce unique micro-Doppler according words with different pronunciations. Following conversion these signals into feature maps, maps categorized identified. recognition...

This paper presents a Concurrent Sampling (CS) method for measuring multitude of analog DC voltages concurrently using local digitization. Boolean results after digitization are routed in an IJTAG compatible fashion. Analog quantities no longer across the die, thus overcoming several limitations Test Buses. Furthermore, proposed enables real-time measurement voltages, addressing growing need Automotive test and reliability. The is applied to circuit consisting widely used blocks such as...

Nuclear receptor subfamily 4 group A member 1 (NR4A1) acts as a myogenic factor in muscle development and regeneration; however, it remains unclear how Nr4a1 regulates myoblast physiology. In this study, report role for Nr4a1-mediated regulation of cell adhesion tissue. Nr4a1-overexpression myoblast, Nr4a1-konckdown mice gastrocnemius following an injection with adenovirus vector expression (Nr4a1-AAV) were used to observe the changes adhesion. was found enhance cell-cell contact molecule...

This paper presents a simple structure to extract V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">GO</sub> , the silicon bandgap voltage at zero Kelvin. Based on traditional Kuijk structure, third diode with temperature constant current is used curvature TlnT term. A novel Gm cell-based summer proposed perform correction. single trimming method implemented trim out PTAT errors and calibrate gain of summer. The reference circuit simulated in...

This paper presents a clock-less digital pulse stretcher which takes short as input and produces detectable that is longer than required minimum duration. The proposed structure has high sensitivity to width height capable of detecting deep sub-nanosecond pulses. enables wide variety applications ranging from characterization radiation-induced single-event transients detection glitch attacks tamper resistance for security. Implementation the in 130nm process validates analytical...

Gradient errors in device arrays cause mismatch between parameters, which turn degrade linearity performance of data converters realized with these arrays. A practical "outputs averaging" technique for string DACs is presented to release complex routing problems gradient reduction patterns. An N-bit divided into multiple substrings and the substrings' outputs are averaged reduce induced nonlinearity. novel layout methodology, called "periodic INL shift", further developed suppress quadratic...

This paper presents an analog duty cycle corrector with feedback. A differential charge pump fast startup is used to detect the error and outputs a control voltage for current-starved inverters adjust pulse width. The current designed be adaptive input frequency, so wide frequency range achieved without requiring large load capacitor. circuit in 130nm CMOS process can correct 4-100 MHz clocks 25-75% range. simulation results show that output limited 1.5% power consumption 50 μW at 100 MHz.

A general methodology of device array mismatch characterization is introduced, analyzed and verified. Instead measuring each device's parameter individually, the configured as a data converter information extracted from differential linearity (DNL) converter. Systematic random are characterized separately using proposed decomposition method with robustness to additive measurement noise. An 8-bit high precision resistor fabricated in Globalfoundries 0.13μm TaN thin film process. Measurement...

Abstract Background : Traditionally, it is believed that large tumor suppressor 1 (LATS1) a negative regulator of oncogene. But the latest research showed LATS1 has an opposite effect in some tumors. We found cancer-promoting BLCA, but specific mechanism unknown. Methods RNAi method was used for related genetic functional analysis. CCK-8 and colony formation assay were to explore cellular viabilities proliferation BLCA cells transfected with siRNAs (si-LATS1), vitro. Flow Cytometry (FCM)...