A5031650276- Viral Infections and Immunology Research
- Animal Disease Management and Epidemiology
- Immune cells in cancer
- Pediatric health and respiratory diseases
- Cytokine Signaling Pathways and Interactions
- Urinary Tract Infections Management
- PARP inhibition in cancer therapy
- Chemotherapy-induced cardiotoxicity and mitigation
- Immune Response and Inflammation
- German Literature and Culture Studies
- T-cell and B-cell Immunology
- Radiation Therapy and Dosimetry
- Herpesvirus Infections and Treatments
- Pharmacological Receptor Mechanisms and Effects
- Whipple's Disease and Interleukins
- Immune Cell Function and Interaction
- Surgical site infection prevention
- Nosocomial Infections in ICU
- Historical Studies and Socio-cultural Analysis
- DNA Repair Mechanisms
- Pelvic floor disorders treatments
- Viral gastroenteritis research and epidemiology
- Immunotherapy and Immune Responses
- Cardiac Ischemia and Reperfusion
- Retinal Development and Disorders
Université de Toulouse
2023-2024
École Nationale Vétérinaire de Toulouse
2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2024
Dynamique Microbienne associée aux Infections Urinaires et Respiratoires
2022-2023
Université Clermont Auvergne
2015-2022
Inserm
2018-2022
Clermont Université
2015-2022
Interaction Hôtes Agents Pathogènes
2021
Centre de Physiopathologie de Toulouse-Purpan
2019
Centre National de la Recherche Scientifique
2017-2019
Enterovirus 71 (EV-71) is involved in epidemics of hand, foot, and mouth disease (HFMD) has been reported to occur with severe neurological complications eastern south-east Asia. In other geographical areas, the transmission this virus poorly understood. We used large sequence datasets (of gene encoding viral protein 1, VP1) a Bayesian phylogenetic approach compare molecular epidemiology spread patterns EV-71 subgenogroups B4, B5, C1, C2, C4 Europe relative parts world. For study, European...
The mammary gland is unique in female mammals. Mammary tissue undergoes development and remodeling during lactation, a stage associated with high susceptibility to bacterial infections, inducing an inflammatory condition called mastitis. Although the immune response of has been subject intense research improve prevention treatment efficacy, precise definition its composition at this particular physiological still missing. We combined single-cell RNA-Seq, flow cytometry, three-dimensional...
ABSTRACT Coxsackievirus A16 (CV-A16; Picornaviridae ) is an enterovirus (EV) type associated with hand, foot, and mouth disease (HFMD) in children. To investigate the spatial spread of CV-A16, we used viral sequence data sampled during a prospective sentinel surveillance HFMD France (2010 to 2014) phylogenetic reconstruction. A set 168 VP1 sequences was assembled 416 publicly available various geographic origins. The CV-A16 reported were assigned two clades, genogroup B previously...
The Triple-Negative Breast Cancer subtype (TNBC) is particularly aggressive and heterogeneous. Thus, Poly-ADP-Ribose Polymerase inhibitors were developed to improve the prognosis of patients treatment protocols are still being evaluated. In this context, we modelized efficacy Olaparib (i.e., 5 50 µM), combined with fractioned irradiation × 2 Gy) on two TNBC cell lines MDA-MB-231 (BRCAness) SUM1315 (BRCA1-mutated). 2D culture for both models, clonogenicity drop was 95-fold higher after µM 10...
The role of suppressor cytokine signaling (SOCS)2 in anti-infective bacterial immunity has been poorly investigated compared to other members the SOCS family.
Dendritic cells (DC) form a collection of antigen-presenting that are distributed throughout the body. Conventional DC (cDC) which include cDC1 and cDC2 subsets, plasmacytoid (pDC) constitute two major ontogenically distinct populations. The pDC complete their differentiation in bone-marrow (BM) while cDC subsets derive from pre-committed precursors, pre-cDC, seed lymphoid non-lymphoid tissues where they further differentiate into mature cDC2. Within different tissues, express phenotype...
Abstract Oxidative stress plays an important role in the ageing of retina and pathogenesis retinal diseases such as age‐related macular degeneration (ARMD). Hydrogen peroxide is a reactive oxygen species generated by photo‐excited lipofuscin that accumulates during pigment epithelium (RPE), accumulation associated with ARMD. Iron also age RPE may contribute to ARMD source oxidative stress. The aim this work was investigate effects L‐Citrulline (CIT), naturally occurring amino acid known...
Abstract The involvement of suppressor cytokine signaling (SOCS)2 in anti-infective bacterial immunity remains largely undetermined compared to other members the SOCS family. We developed a mouse model expressing loss function R96C SOCS2 point mutation characterize response macrophages Staphylococcus aureus and its TLR-ligand derivatives. resumes observations gigantism done Socs2-/- mice. Stimulation bone-marrow-derived with various TLR-2 ligands showed upregulation pro-inflammatory...
Bei 150 Tumor-Patienten wurden kardiologische Verlaufskontrollen mit EKG, UKG und Bestimmung der STI unter einer kardiotoxischen Therapie Anthracyclinen durchgeführt. 10 Patienten ent-wickelte sich eine ADM-CMP, die bei 4 ohne sichere klinische Symptomatik verlief. In alien Fallen war VFR vermin-dert, aus den errechnete PEP/LVET sowie PEPI pathologisch erhöht. Die elektrokardiographisch gewonnenen Parameter erwiesen als unzuverlässig. Extrakardiale Ursachen schränken Aussage von ein, durch...
Unter kardiotoxischer Therapie mit Anthracyclin (ADM) wurden bei 255 Tumorpatienten kardiologische Verlaufskontrollen innerhalb von 4 Jahren EKG, UKG und Ermittlung der STI durchgeführt. Der ausschlaggebende Parameter für die Diagnose einer Kardiomyopathie (CMP) war pathologische Verkürzungsfraktion (VFr) aus dem UKG. Danach entwickelten 23 Patienten eine ADM-CMP, 6 ohne sichere klinische Symptomatik verlief. In alien Fallen VFr vermindert, unter den waren PEP/LVET sowie PEPI pathologisch...