A5039880537- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Advanced Chemical Physics Studies
- Robotics and Sensor-Based Localization
- Spectroscopy and Quantum Chemical Studies
- Molecular spectroscopy and chirality
- Advanced Image and Video Retrieval Techniques
- Health and Medical Research Impacts
- Neural dynamics and brain function
- Animal testing and alternatives
- Mass Spectrometry Techniques and Applications
- Zebrafish Biomedical Research Applications
- Wireless Body Area Networks
- Protein Structure and Dynamics
- Olfactory and Sensory Function Studies
- DNA and Nucleic Acid Chemistry
- Enzyme Structure and Function
- Optical Imaging and Spectroscopy Techniques
- Photoreceptor and optogenetics research
- Nasal Surgery and Airway Studies
- Cell Image Analysis Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Chemical Synthesis and Analysis
- Science, Research, and Medicine
- Ethics in Clinical Research
University of Edinburgh
2018-2022
Discovery Centre
2019
University of Veterinary Medicine Hannover, Foundation
2018
University of Szeged
2013-2017
To determine whether a change in editorial policy, including the implementation of checklist, has been associated with improved reporting measures which might reduce risk bias.The study protocol published at doi: 10.1007/s11192-016-1964-8.Observational cohort study.Articles describing research life sciences Nature journals, submitted after 1 May 2013.Mandatory completion checklist during manuscript revision.(1) Articles before 2013; and (2) similar articles other journals matched for date...
Spatial learning requires estimates of location that may be obtained by path integration or from positional cues. Grid and other spatial firing patterns neurons in the superficial medial entorhinal cortex (MEC) suggest roles behavioral estimation location. However, distinguishing contributions cue-based signals to behaviors is challenging, identified MEC are unclear. We use virtual reality dissociate linear strategies for find mice learn integrate using motor-related self-motion signals,...
Abstract Grid and head direction codes represent cognitive spaces for navigation memory. Pure grid cells generate that have been assumed to be independent of direction, whereas conjunctive representations are tuned a single direction. Here, we demonstrate pure also encode but through distinct mechanisms. We show individual firing fields multiple directions, with the preferred sets directions differing between fields. This local directional modulation is not predicted by previous continuous...
Abstract The ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are widely endorsed but compliance is limited. We sought to determine whether journal-requested completion an checklist improves full with the guidelines. a randomised controlled trial, manuscripts reporting in vivo animal research submitted PLOS ONE (March-June 2015) were allocated either requested or current standard practice. measured change proportion meeting all guideline items between groups. 1,689...
Neurons in the retrohippocampal cortices play crucial roles spatial memory. Many neurons have firing fields that are selectively active at specific locations, with memory for rewarded locations associated reorganization of these fields. Whether this is sole strategy representing memories unclear. Here, we demonstrate during a task encode location through ramping activity extends across segments linear track approaching and following reward, represented by offsets or switches slope activity....
C radicals are typically trigonal planar and thus achiral, regardless of whether they originate from a chiral or an achiral C-atom (e.g., C-H + (•)OH → C• H2O). Oxidative stress could initiate radical formation in proteins when, for example, the H-atom is abstracted Cα-carbon amino acid residue. Electronic structure calculations show that such remains when formed Gly, but small Ala residues. However, longer side-chain containing proteogenic residues studied Asn), provide axis chirality,...
Summary Neurons in the retrohippocampal cortices play crucial roles spatial memory. Many neurons have firing fields that are selectively active at specific locations, with memory for rewarded locations associated reorganisation of these fields. Whether this is sole strategy representing memories unclear. Here, we demonstrate during a task encode location through ramping activity extends within segments linear track approaching and following reward, represented by offsets or switches slope...
Grid and head direction codes represent cognitive spaces for navigation memory. Pure grid cells generate that have been assumed to be independent of direction, whereas conjunctive representations are tuned a single direction. Here, we demonstrate pure also encode but through distinct mechanisms. We show individual firing fields multiple directions, with the preferred sets directions differing between fields. This local directionality is not predicted by previous continuous attractor or...
Questions about information encoded by the brain demand statistical frameworks for inferring relationships between neural firing and features of world. The landmark discovery grid cells demonstrates that neurons can represent spatial through regularly repeating fields. However, influence covariates may be masked in current models cell activity, which employing approaches such as discretizing, aggregating smoothing, are computationally inefficient do not account continuous nature physical...