A5048717614- Neonatal and fetal brain pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Anesthesia and Neurotoxicity Research
- Neonatal Respiratory Health Research
- DNA Repair Mechanisms
- Thermal Regulation in Medicine
- Cardiac Arrest and Resuscitation
- Heart Rate Variability and Autonomic Control
- Cardiac Ischemia and Reperfusion
- Genomics and Chromatin Dynamics
- Maternal Mental Health During Pregnancy and Postpartum
- Adolescent and Pediatric Healthcare
- Congenital Heart Disease Studies
- Cardiovascular Conditions and Treatments
- Metabolism and Genetic Disorders
- Non-Invasive Vital Sign Monitoring
- Nuclear Structure and Function
- S100 Proteins and Annexins
- Ultrasound in Clinical Applications
- Hemodynamic Monitoring and Therapy
- Birth, Development, and Health
- Infectious Encephalopathies and Encephalitis
- Digital Imaging in Medicine
- Hospital Admissions and Outcomes
- Aortic Disease and Treatment Approaches
Aarhus University
2005-2024
Aarhus University Hospital
2015-2024
University of Edinburgh
2019
Regionshospitalet Herning
2009
National Institute on Aging
2003-2005
National Institutes of Health
2003-2005
Cyclooxygenase inhibitors are commonly used in infants with patent ductus arteriosus (PDA), but the benefit of these drugs is uncertain. In this multicenter, noninferiority trial, we randomly assigned echocardiographically confirmed PDA (diameter, >1.5 mm, left-to-right shunting) who were extremely preterm (<28 weeks' gestational age) to receive either expectant management or early ibuprofen treatment. The composite primary outcome included necrotizing enterocolitis (Bell's stage IIa...
To determine whether a change in editorial policy, including the implementation of checklist, has been associated with improved reporting measures which might reduce risk bias.The study protocol published at doi: 10.1007/s11192-016-1964-8.Observational cohort study.Articles describing research life sciences Nature journals, submitted after 1 May 2013.Mandatory completion checklist during manuscript revision.(1) Articles before 2013; and (2) similar articles other journals matched for date...
Werner syndrome (WS) is a premature aging disorder, displaying defects in DNA replication, recombination, repair, and transcription. It has been hypothesized that several WS phenotypes are secondary consequences of aberrant gene expression transcription defect may be crucial to the development syndrome. We used cDNA microarrays characterize 6,912 genes ESTs across panel 15 primary human fibroblast cell lines derived from young donors, old patients. Of analyzed genes, 6.3% displayed...
Abstract Up to 13% of women may experience symptoms depression during pregnancy or in the postpartum period. Depression has been associated with an increased risk adverse neurodevelopmental outcomes child and epigenetic mechanisms could be one biological pathways explain this association. In 844 mother–child pairs from Avon Longitudinal Study Parents Children, we carried out epigenome-wide association study (EWAS) investigate associations between prospectively collected data on maternal...
Birth asphyxia, which causes hypoxic-ischemic encephalopathy (HIE), accounts for 0.66 million deaths worldwide each year, about a quarter of the world's 2.9 neonatal deaths. Animal models HIE have contributed to understanding pathophysiology in HIE, and highlighted dynamic process that occur brain injury due perinatal asphyxia. Thus, animal studies suggested time-window post-insult treatment strategies. Hypothermia has been tested as pdiglet subsequently proven effective clinical trials....
Abstract Background Early biomarkers are needed to improve diagnosis and support antibiotic stewardship in neonatal sepsis. Heart rate variability (HRV) is proposed as such a biomarker. However, there lack of studies term newborns. Infusion lipopolysaccharide (LPS) from Escherichia coli induces systemic inflammation comparable sepsis We aimed study the effect LPS induced on HRV newborn piglets. Methods Baseline was recorded for 1 h. This control period compared hourly each piglet ( n = 9)...
Therapeutic hypothermia is the only proven neuroprotective treatment for hypoxic-ischemic encephalopathy. However, studies have questioned whether therapeutic may benefit newborns subjected to infection or inflammation before a insult. We aimed compare newborn piglets with lipopolysaccharide-sensitized hypoxia-ischemia treated and without regards measures of neuroprotection.A total 32 male female were included in this randomized experimental study. Lipopolysaccharides from Escherichia coli...
Controversy exists about the optimal management of a patent ductus arteriosus (PDA) in preterm infants. A persistent PDA is associated with neonatal mortality and morbidity, but causality remains unproven. Although both pharmacological and/or surgical treatment are effective closure, this has not resulted an improved outcome. In most infants, will eventually close spontaneously, hence potentially increases risk iatrogenic adverse effects. Therefore, expectant gaining interest, even absence...
Abstract There are a variety of devices that quantify biological properties cerebral tissue. Installing such device will cause local insertion trauma, which affect early measurements. Current literature proposes minimum one hour observation before acquiring first measurements when using microdialysis. It is unknown whether this applies to other intracerebral devices. We therefore aimed investigate time needed reach steady state microdialysis and two probes in piglet model. Ten newborn...
Introduction: Hypoxic ischemic encephalopathy (HIE) is one of the major causes death and disability in children worldwide. Apart from supportive care, only established treatment for HIE therapeutic hypothermia (TH). As TH partly neuroprotective; there a need additional therapies. Intermittent periods limb ischemia, called remote postconditioning (RIPC), have been shown to be neuroprotective after rats piglets. However, it unknown whether this will add effect TH. In piglet model we tested was...
Decreased heart rate variability (HRV) may be a biomarker of brain injury severity in neonatal hypoxic-ischemic encephalopathy for which therapeutic hypothermia is standard treatment. While influence the degree injury; also affect HRV per se and obscure potential association between encephalopathy. Previous results are conflicting. This study aimed to investigate effect on healthy, anaesthetised, newborn piglets. Six healthy piglets were anaesthetised. Three first kept normothermic...
Hypoxic ischemic encephalopathy (HIE) after a perinatal insult is dynamic process that evolves over time. Therapeutic hypothermia (TH) standard treatment for severe to moderate HIE. There lack of evidence on the temporal change and interrelation underlying mechanisms constitute HIE under normal hypothermic conditions. We aimed describe early changes in intracerebral metabolism hypoxic-ischemic piglets treated with without TH controls.Three devices were installed into left hemisphere 24...
Comment on: The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation addition to cell cycle DNA damage responses.Ramachander V.N. Turaga, Eric R. Paquet, Mari Sild, Julien Vignard, Chantal Garand, F. Brad Johnson, Jean-Yves Masson Michel Lebel
<b><i>Background:</i></b> The training required for accurate assessment of umbilical catheter placement by ultrasonography (US) is unknown. <b><i>Objective:</i></b> To describe the learning curve and provide an estimate accuracy physicians’ US examinations (US skills) self-confidence when examining tip placement. <b><i>Methods:</i></b> Twenty-one physicians with minimal experience in completed a 1.5-hour eLearning...
Birth asphyxia, which causes hypoxic-ischemic encephalopathy (HIE), accounts for 0.66 million deaths worldwide each year, about a quarter of the world's 2.9 neonatal deaths. Animal models HIE have contributed to understanding pathophysiology in HIE, and highlighted dynamic process that occur brain injury due perinatal asphyxia. Thus, animal studies suggested time-window post-insult treatment strategies. Hypothermia has been tested as pdiglet subsequently proven effective clinical trials....
<b><i>Background:</i></b> Biomarkers may qualify diagnosis, treatment allocation, and prognostication in neonatal encephalopathy. Biomarker development is challenged by competing etiologies, inter-individual genetic variability, a lack of specific markers. To address these challenges, we used standardized hypoxic-ischemic (HI) encephalopathy model with pre- post-HI sampling cerebrospinal fluid (CSF) plasma. <b><i>Objectives:</i></b> The study...