A5045342203- Meta-analysis and systematic reviews
- Animal testing and alternatives
- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Ischemic Stroke Management
- Biomedical Text Mining and Ontologies
- Ethics in Clinical Research
- Cell Image Analysis Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Biochemical effects in animals
- Thermal Regulation in Medicine
- Health and Medical Research Impacts
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Photoacoustic and Ultrasonic Imaging
- Neurological Disease Mechanisms and Treatments
- Cardiac Ischemia and Reperfusion
- Metabolomics and Mass Spectrometry Studies
- Antioxidants, Aging, Portulaca oleracea
- Pain Mechanisms and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Plant-based Medicinal Research
- Anesthesia and Neurotoxicity Research
- Hydrogen's biological and therapeutic effects
- Statistical Methods in Clinical Trials
- Neurological Disorders and Treatments
- Cancer Treatment and Pharmacology
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2020-2025
Charité - Universitätsmedizin Berlin
2020-2021
Humboldt-Universität zu Berlin
2020-2021
Freie Universität Berlin
2020-2021
University College London
2021
University of Edinburgh
2014-2019
Imperial College London
2018
McCann Associates (United States)
2018
University of Calgary
2017
Florey Institute of Neuroscience and Mental Health
2013-2015
To determine whether a change in editorial policy, including the implementation of checklist, has been associated with improved reporting measures which might reduce risk bias.The study protocol published at doi: 10.1007/s11192-016-1964-8.Observational cohort study.Articles describing research life sciences Nature journals, submitted after 1 May 2013.Mandatory completion checklist during manuscript revision.(1) Articles before 2013; and (2) similar articles other journals matched for date...
The replicability of research results has been a cause increasing concern to the scientific community. long-held belief that experimental standardization begets also recently challenged, with observation reduction variability within studies can lead idiosyncratic, lab-specific cannot be replicated. An alternative approach is to, instead, deliberately introduce heterogeneity, known as “heterogenization” design. Here, we explore novel perspective in heterogenization program meta-analysis...
<h3>Background</h3> Meta-analysis of preclinical data is used to evaluate the consistency findings and inform design conduct future studies. Unlike clinical meta-analysis, often involve many heterogeneous studies reporting outcomes from a small number animals. Here, we review methodological challenges in meta-analysis estimating explaining heterogeneity treatment effects. <h3>Methods</h3> Assuming aggregate-level data, focus on two topics: (1) estimation using commonly methods meta-analysis:...
Abstract Oxidative stress contributes to the progression of brain injury following ischemic stroke and reperfusion. NADPH oxidase is a well‐established source superoxide in vascular disease, but its contribution tissue has yet be fully elucidated. Here we show spatiotemporal profile subunits Nox2 Nox4 concurrent generation induced by middle cerebral artery constriction conscious rats. mRNA was progressively up‐regulated both ipsilateral cortex striatum from 6 hr 7 days poststroke also...
In both the human and animal literature, it has largely been assumed that edema is primary cause of intracranial pressure (ICP) elevation after stroke more equates to higher ICP. We recently demonstrated a dramatic ICP 24 hours small ischemic strokes in rats, with minimal edema. This was completely prevented by short-duration moderate hypothermia soon stroke. Here, our aims were determine importance whether mild could prevent rise. Experimental performed rats. monitored (35 °C) or (32.5...
Oxidative stress caused by an excess of reactive oxygen species (ROS) is known to contribute stroke injury, particularly during reperfusion, and antioxidants targeting this process have resulted in improved outcomes experimentally. Unfortunately these improvements not been successfully translated the clinical setting. Targeting source oxidative may provide a superior therapeutic approach. The NADPH oxidases are family enzymes dedicated solely ROS production pre-clinical animal studies shown...
In an effort to better utilize published evidence obtained from animal experiments, systematic reviews of preclinical studies are increasingly more common—along with the methods and tools appraise them (e.g., SYstematic Review Center for Laboratory Experimentation [SYRCLE’s] risk bias tool). We performed a cross-sectional study sample recent (2015–2018) examined range epidemiological characteristics used 46-item checklist assess reporting details. identified 442 across 43 countries in 23...
Background Intracranial pressure elevation, peaking three to seven post-stroke is well recognized following large strokes. Data small–moderate stroke are limited. Therapeutic hypothermia improves outcome after cardiac arrest, strongly neuroprotective in experimental stroke, and under clinical trial stroke. Hypothermia lowers elevated intracranial pressure; however, rebound elevation neurological deterioration may occur during rewarming. Hypotheses ( 1 ) increases 24 h moderate small 2...