A5083804911- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Heart Rate Variability and Autonomic Control
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Anesthesia and Neurotoxicity Research
- Thermal Regulation in Medicine
- Infant Development and Preterm Care
- Non-Invasive Vital Sign Monitoring
- Advanced MRI Techniques and Applications
- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Advanced NMR Techniques and Applications
- Infectious Encephalopathies and Encephalitis
- Fetal and Pediatric Neurological Disorders
- Neonatal Health and Biochemistry
- Infant Health and Development
- Optical Imaging and Spectroscopy Techniques
Aarhus University Hospital
2019-2024
Aarhus University
2019-2024
Abstract Background Early biomarkers are needed to improve diagnosis and support antibiotic stewardship in neonatal sepsis. Heart rate variability (HRV) is proposed as such a biomarker. However, there lack of studies term newborns. Infusion lipopolysaccharide (LPS) from Escherichia coli induces systemic inflammation comparable sepsis We aimed study the effect LPS induced on HRV newborn piglets. Methods Baseline was recorded for 1 h. This control period compared hourly each piglet ( n = 9)...
Exposure to hypoxic-ischaemia (HI) is consistently followed by a delayed fall in cerebral perfusion. In preterm fetal sheep this associated with impaired oxygenation, consistent mismatch between perfusion and metabolism. the present study we tested hypothesis that alpha-adrenergic inhibition after HI would improve perfusion, so attenuate reduce neural injury. Chronically instrumented (0.7 gestation) received sham-HI (n = 10) or induced complete umbilical cord occlusion for 25 minutes. From...
Abstract There are a variety of devices that quantify biological properties cerebral tissue. Installing such device will cause local insertion trauma, which affect early measurements. Current literature proposes minimum one hour observation before acquiring first measurements when using microdialysis. It is unknown whether this applies to other intracerebral devices. We therefore aimed investigate time needed reach steady state microdialysis and two probes in piglet model. Ten newborn...
Introduction: Hypoxic ischemic encephalopathy (HIE) is one of the major causes death and disability in children worldwide. Apart from supportive care, only established treatment for HIE therapeutic hypothermia (TH). As TH partly neuroprotective; there a need additional therapies. Intermittent periods limb ischemia, called remote postconditioning (RIPC), have been shown to be neuroprotective after rats piglets. However, it unknown whether this will add effect TH. In piglet model we tested was...
Decreased heart rate variability (HRV) may be a biomarker of brain injury severity in neonatal hypoxic-ischemic encephalopathy for which therapeutic hypothermia is standard treatment. While influence the degree injury; also affect HRV per se and obscure potential association between encephalopathy. Previous results are conflicting. This study aimed to investigate effect on healthy, anaesthetised, newborn piglets. Six healthy piglets were anaesthetised. Three first kept normothermic...
Hypoxic ischemic encephalopathy (HIE) after a perinatal insult is dynamic process that evolves over time. Therapeutic hypothermia (TH) standard treatment for severe to moderate HIE. There lack of evidence on the temporal change and interrelation underlying mechanisms constitute HIE under normal hypothermic conditions. We aimed describe early changes in intracerebral metabolism hypoxic-ischemic piglets treated with without TH controls.Three devices were installed into left hemisphere 24...
Abstract Early biomarkers of cerebral damage are essential for accurate prognosis, timely intervention, and evaluation new treatment modalities in newborn infants with hypoxia ischemia at birth. Hyperpolarized 13 C magnetic resonance imaging (MRI) is a novel method which to quantify metabolism vivo unprecedented sensitivity. We aimed investigate the applicability hyperpolarized MRI piglet model whether this may identify early changes after standardized hypoxic–ischemic (HI) insult. Six...
Abstract Background: Epinephrine is an integral component of neonatal resuscitation guidelines, despite sparse evidence. The association between advanced cardiopulmonary (CPR) and poor neurodevelopment well known, epinephrine may improve short-term survival but at the cost neurologic outcome. Our objectives were to investigate effect vs placebo in a piglet model hypoxic cardiac arrest (CA) by: 1) return spontaneous circulation (ROSC), 2) time-to-ROSC, 3) markers CNS outcome by magnetic...