A5067486227- Proteoglycans and glycosaminoglycans research
- Cell Adhesion Molecules Research
- Wound Healing and Treatments
- Osteoarthritis Treatment and Mechanisms
- Nanoparticle-Based Drug Delivery
- Antimicrobial agents and applications
- Polydiacetylene-based materials and applications
- Antimicrobial Peptides and Activities
- Connective tissue disorders research
- Polymer Surface Interaction Studies
- Silk-based biomaterials and applications
- Bone Tissue Engineering Materials
- Acoustic Wave Resonator Technologies
- Dendrimers and Hyperbranched Polymers
Martin Luther University Halle-Wittenberg
2016-2022
Abstract Inflammation and subsequent fibrotic encapsulation that occur after implantation of biomaterials are issues fostered efforts in designing novel biocompatible materials to modulate the immune response. In this study, glycosaminoglycans (GAG) like hyaluronic acid (HA) heparin (Hep) possess anti‐inflammatory activity were covalently bound NH 2 ‐modified surfaces using EDC/NHS cross‐linking chemistry. Immobilization physical surface properties characterized by atomic forces microscopy,...
Background The inflammatory responses evoked by artificial organs and implantation of devices like biosensors guide wires can lead to acute chronic inflammation, largely limiting the functionality longevity with negative effects on patients. Aims present study aimed reduce biomaterials covalent immobilization glycosaminoglycans (GAGs) amino-terminated surfaces used as model here. Methods Results Water contact angle (WCA) zeta potential measurements showed a significant increase in...
Immune response to biomaterials can produce chronic inflammation and fibrosis leading implant failure, which is related the surface properties of biomaterials. This work describes preparation characterization polyelectrolyte multilayer (PEM) coatings that combine anti-inflammatory activity heparin as polyanion with potential release Naproxen, a nonsteroidal drug from polymeric nanoparticles (NP) cationic charge. The multilayers were characterized by physical methods estimate growth,...
The use of implants can be hampered by chronic inflammatory reactions, which may result in failure the implanted device. To prevent such an outcome, present study examines anti-inflammatory properties surface coatings made either hyaluronic acid (HA) or heparin (Hep) combination with chitosan (Chi) prepared as multilayers through layer-by-layer (LbL) technique. glycosaminoglycan (GAG)-modified surfaces were characterized terms topography, thickness and wettability. Results showed a higher...
Emerging and re-emerging infections are a global threat driven by the development of antimicrobial resistance due to overuse agents poor infection control practices. Implantable devices particularly susceptible such formation microbial biofilms. Furthermore, introduction implants into body often results in inflammation foreign reactions. The anti-inflammatory properties gallium (Ga) have been recognized but not yet utilized effectively improve implantable device integration. defensin (De,...
Abstract Biphasic calcium phosphate (BCP) materials are widely employed as bone substitute due to their resorption/degradation properties. Inflammation after implantation of such represents a prerequisite for tissue repair and regeneration but can be also problematic if it is not only transient followed by fibrosis scarring. Here, we modified BCP covalently with hyaluronan (HA) heparin (Hep), glycosaminoglycans that possess anti‐inflammatory Beside the characterization particle surface...