A5038200930- Wnt/β-catenin signaling in development and cancer
- PI3K/AKT/mTOR signaling in cancer
- Chronic Myeloid Leukemia Treatments
- Hippo pathway signaling and YAP/TAZ
- Cancer Cells and Metastasis
- Protein Tyrosine Phosphatases
- Chronic Lymphocytic Leukemia Research
- Cancer-related gene regulation
- RNA Research and Splicing
- Management Systems and Quality Improvement
- Caveolin-1 and cellular processes
- T-cell and Retrovirus Studies
- Axon Guidance and Neuronal Signaling
- Ferroptosis and cancer prognosis
- Ovarian cancer diagnosis and treatment
- MicroRNA in disease regulation
- Monoclonal and Polyclonal Antibodies Research
- Galectins and Cancer Biology
- Cancer, Lipids, and Metabolism
- Receptor Mechanisms and Signaling
- FOXO transcription factor regulation
- Management and Organizational Practices
- Acute Lymphoblastic Leukemia research
- Computational Drug Discovery Methods
- Protein Kinase Regulation and GTPase Signaling
Columbia University Irving Medical Center
2024
Tampere University
2017-2022
Tampere University Hospital
2019
Tech Foundation
2017
Abstract Glucocorticoids are routinely used in the clinic as anti-inflammatory and immunosuppressive agents well adjuvants during cancer treatment to mitigate undesirable side effects of chemotherapy. However, recent studies have indicated that glucocorticoids may negatively impact efficacy chemotherapy by promoting tumor cell survival, heterogeneity, metastasis. Here, we show dexamethasone induces upregulation ROR1 expression ovarian (OC), including platinum-resistant OC. Increased resulted...
Ovarian cancer has the highest mortality rate of all gynecologic malignancies. Identification new biomarkers is highly needed due to its late diagnosis and high recurrence rate. The objective this study was identify mechanisms therapy resistance potential by analyzing mRNA protein expression from samples derived patients with platinum-sensitive -resistant ovarian (total cohort n = 53). data revealed candidates for targeted therapies, such as GREB1 ROR2. We showed that development platinum...
Background: Dysregulated lipid metabolism is emerging as a hallmark in several malignancies, including ovarian cancer (OC). Specifically, metastatic OC highly dependent on lipid-rich omentum. We aimed to investigate the therapeutic value of targeting OC. For this purpose, we studied role PCSK9, cholesterol-regulating enzyme, cell survival and its downstream signaling. also investigated cytotoxic efficacy small library metabolic (n = 11) mTOR 10) inhibitors using lines 8) ex vivo...
Mantle cell lymphoma (MCL) is an aggressive form of non-Hodgkin B-cell with poor prognosis due to drug resistance. Introduction the Bruton tyrosine kinase (BTK) inhibitor ibrutinib has markedly improved MCL therapy outcome, but resistance remains a challenge. The selective cell-surface expression oncogenic receptor kinase-like orphan 1 (ROR1) pseudokinase in hematological malignancies made this promising candidate for targeted therapy. We sought identify molecular mechanism underlying...
Abstract Most patients with ovarian cancer (OC) are diagnosed at a late stage when there very few therapeutic options and poor prognosis. This is due to the lack of clearly defined underlying mechanisms or an oncogenic addiction that can be targeted pharmacologically, unlike other types cancer. Here, we identified protein tyrosine kinase 7 (PTK7) as potential new target in OC following multiomics approach using genetic pharmacological interventions. We performed proteomics analyses upon PTK7...
Abstract ROR1, ROR2, and PTK7 are Wnt ligand-binding members of the receptor tyrosine kinase family. Despite their lack catalytic activity, these receptors regulate skeletal, cardiorespiratory, neurological development during embryonic fetal stages. However, overexpression in adult tissue is strongly connected to tumor metastasis, suggesting a strong pharmacological potential for molecules. Wnt5a ligand can activate receptors, but lead divergent signaling functional outcomes through...
Receptor tyrosine kinases (RTKs) orchestrate embryonic development and tissue homeostasis by controlling key cellular processes like growth proliferation. Consequently, the vast majority of 58 RTKs in humans are linked to cancer or metabolic disorders. For instance, represent known oncogenic drivers (such as EGFR non-small cell lung cancer), contribute hallmarks VEGFR pro-tumor angiogenesis), mediate resistance therapeutics hormones Insulin diabetes). Classically, transduce signals through...