Hee Jae Lee

ORCID: 0000-0002-7816-6444
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About
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Research Areas
  • Plant Physiology and Cultivation Studies
  • Horticultural and Viticultural Research
  • Berry genetics and cultivation research
  • Phytochemicals and Antioxidant Activities
  • Postharvest Quality and Shelf Life Management
  • Fermentation and Sensory Analysis
  • Photosynthetic Processes and Mechanisms
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Plant Pathogens and Fungal Diseases
  • Cancer Immunotherapy and Biomarkers
  • Plant Reproductive Biology
  • Natural product bioactivities and synthesis
  • Immune Cell Function and Interaction
  • Fungal Plant Pathogen Control
  • Food Quality and Safety Studies
  • Plant Gene Expression Analysis
  • Inflammasome and immune disorders
  • Immunotherapy and Immune Responses
  • Colorectal Cancer Surgical Treatments
  • Healthcare and Venom Research
  • Neuroendocrine regulation and behavior
  • Immune Response and Inflammation
  • Light effects on plants
  • Neuroscience and Neuropharmacology Research
  • Pesticide and Herbicide Environmental Studies

Kangwon National University
2014-2024

Seoul National University
2014-2024

Korea Institute of Fusion Energy
2024

Yonsei University
2022-2024

Jeonbuk National University
2021-2024

University of Georgia
2024

Neogen (United States)
2021-2024

Kumoh National Institute of Technology
2023

Syracuse University
2022-2023

Ulsan College
2015-2021

The preparation from Percoll-purified cucumber (Cucumis sativus)etiochloroplasts of a subplastidic membrane fraction that is capable high rates Mg insertion into protoporphyrin IX described. plastid stroma was inactive when used either alone or in combination with the fraction. Successful required Mg-protoporphyrin chelatase first stabilized by its substrate. This achieved lysing plastids fortified hypotonic medium containing prior to ultracentrifugation and separation membranes....

10.1104/pp.99.3.1134 article EN PLANT PHYSIOLOGY 1992-07-01

The level of tumor-infiltrating lymphocytes and presence tertiary lymphoid structures are significant prognostic predictive factors in primary breast cancer. However, the understanding about differences at various metastatic sites or between tumors is limited. A total 335 cases cancer from four (lung, liver, brain, ovary) were included. We analyzed percentages sites. mean lung metastases was higher than ovary, matched tumors, while liver brain showed lower levels tumors. Tertiary only found...

10.1038/s41379-018-0113-8 article EN publisher-specific-oa Modern Pathology 2018-08-28

In recent years, a new form of influencer marketing, led by virtual ambassadors has appeared. Motivated influencers’ (VI) potentials as corporate social responsibility (CSR) messengers, the study (1) compared persuasive power VIs with different humanness; and (2) examined how humanness endorser-CSR fit interplay in affecting source credibility via drawing upon expectancy violation theory. An online experiment two (type VI: humanlike vs. cartoonlike) × (endorser-CSR fit: high low)...

10.1080/10496491.2022.2163041 article EN Journal of Promotion Management 2022-12-29

Virtual influencers (VIs) are computer-generated avatars whose purpose is to exert influences on social media. The unique features of VIs have the potential overcome several shortcomings that plague human (HIs) while maintaining advantages HIs. Hence, this study (1) compares persuasiveness HIs and with different humanlike visual cues; (2) examines how interactivity humanness interplay in determining source credibility; (3) investigates credibility endorsers can promote corporate...

10.1080/15252019.2023.2189036 article EN Journal of Interactive Advertising 2023-05-22

Black raspberry seed extract and its tannin fraction were characterized their antioxidant anti-inflammatory activities compared to grape fraction. Tannin of black was mostly composed ellagitannins including pedunculagin, sanguiin H6 H10 isomers galloyl-bis-HHDP glucose isomer, while that proanthocyanidins proanthocyanidin dimers, trimers, tetramers, pentamers, monogallates hexamers. Antioxidant the extract, measured by polyphenol content, FRAP, DPPH ABTS assays, significantly higher than...

10.1111/jfbc.12044 article EN Journal of Food Biochemistry 2013-08-05

Pathogen expulsion from the gut is an important defense strategy against infection, but little known about how interaction between intestinal microbiome and host immunity modulates defecation. In Drosophila melanogaster, dual oxidase (Duox) kills pathogenic microbes by generating microbicidal reactive oxygen species (ROS), hypochlorous acid (HOCl) in response to bacterially excreted uracil. The physiological function of enzymatically generated HOCl is, however, unknown aside its...

10.1371/journal.pgen.1005773 article EN cc-by PLoS Genetics 2016-01-04

Ewing sarcoma (ES) is a highly malignant carcinoma prevalent in children and most frequent the second decade of life. It mostly occurs due to t(11;22) (q24;q12) translocation. This translocation encodes oncogenic fusion protein EWS/FLI (Friend leukemia integration 1 transcription factor), which acts as an aberrant factor deregulate target genes essential for cancer. Traditionally, flavonoids from plants have been investigated against viral cancerous diseases shown some promising results...

10.3390/molecules28010414 article EN cc-by Molecules 2023-01-03

Abstract: In the present study, underlying protective mechanism of melatonin on kainic acid (KA)‐induced excitotoxicity was examined in hippocampus mice. KA, administered intracerebroventricularly (i.c.v.), induced marked neuronal cell death with concurrent microglial activation and subsequent induction inducible nitric oxide synthase (iNOS) hippocampus. Histopathological analysis demonstrated that (10 mg/kg), 1 hr prior to attenuated KA‐induced pyramidal neurons CA3 region. Melatonin...

10.1111/j.1600-079x.2005.00283.x article EN Journal of Pineal Research 2005-10-25

Avicularin, quercetin-3-<TEX>${\alpha}$</TEX>-L-arabinofuranoside, has been reported to possess diverse pharmacological properties such as anti-inflammatory and anti-infectious effects. However, the underlying mechanism by which avicularin exerts its activity not clearly demonstrated. This study aimed elucidate of in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. Avicularin significantly inhibited LPS-induced excessive production pro-inflammatory mediators nitric oxide (NO)...

10.4062/biomolther.2012.20.6.532 article EN Biomolecules & Therapeutics 2012-11-30

Low-grade chronic inflammation (metaflammation) is a major contributing factor for the onset and development of metabolic diseases, such as type 2 diabetes, obesity, cardiovascular disease. Nicotinamide riboside (NR), which present in milk beer, functional vitamin B3 having advantageous effects on regulation. However, anti-inflammatory capacity NR unknown. This study evaluated whether modulates hepatic nucleotide binding oligomerization domain-like receptor family, pyrin domain containing 3...

10.1089/jmf.2015.3439 article EN Journal of Medicinal Food 2015-05-14

Machine learning algorithms have been increasingly applied in drug development due to their efficiency and effectiveness. learning-based repurposing can contribute the identification of novel therapeutic applications for drugs with other indications. The current study used a trained machine model screen vast chemical library new JAK2 inhibitors, biological activities which were reported. Reference comprising 1911 compounds, experimentally determined IC50 values. To generate input model,...

10.1021/acs.jcim.3c01090 article EN Journal of Chemical Information and Modeling 2023-10-31

BACKGROUND: Sleep deprivation (SD) affects 20–30% of children and is known to impair cognitive functions, particularly memory. Despite its impact, there currently no standardized treatment. Evidence from both adult animal human suggests that N-acetylcysteine (NAC) possesses neuroprotective properties. This study was conducted evaluate the effects NAC on memory deficits induced by SD in juvenile rats.METHODS: Juvenile Sprague-Dawley rats were subjected using modified multiple platform method....

10.18585/inabj.v17i2.3445 article EN cc-by-nc The Indonesian Biomedical Journal 2025-04-01
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