A5100722091- Asthma and respiratory diseases
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Receptor Mechanisms and Signaling
- Immune Response and Inflammation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Musculoskeletal pain and rehabilitation
- T-cell and B-cell Immunology
- Spine and Intervertebral Disc Pathology
- Lipid metabolism and biosynthesis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Eosinophilic Esophagitis
- Phytochemistry and Biological Activities
- Neuropeptides and Animal Physiology
- Allergic Rhinitis and Sensitization
- Pancreatic function and diabetes
- Genetic Mapping and Diversity in Plants and Animals
- Neonatal Respiratory Health Research
- Natural product bioactivities and synthesis
- Mast cells and histamine
- Neurotransmitter Receptor Influence on Behavior
- Single-cell and spatial transcriptomics
- Galectins and Cancer Biology
- Reproductive Physiology in Livestock
- Peptidase Inhibition and Analysis
Korea Research Institute of Bioscience and Biotechnology
2013-2025
Jaseng Hospital of Korean Medicine
2020-2024
Weatherford College
2021-2024
Korea University of Science and Technology
2023
Gachon University
2022
Boston Children's Hospital
2019
Harvard University
2019
Gyeongsang National University
2014
National Institute of Animal Science
2011
University of Chicago
2002-2006
The purpose of our study was to investigate changes in immunological parameters induced by weaning stress (including milk restriction) calves.Fifteen Holstein calves were subjected at 6 weeks age.Blood samples collected -14, -7, -2, 1, 3, and 5 days post-weaning (DPW; 0 DPW = 42 days).Weaning caused significant (p ＜ 0.01) increases the neutrophil (NE):lymphocyte (LY) ratio with a 0.05) reduction LYs.The concentration acute-phase proteins (haptoglobin serum amyloid A) also increased...
G-protein coupled receptor 43 (GPR43) serves as a for short-chain fatty acids (SCFAs), implicated in neutrophil migration and inflammatory cytokine production. However, the intracellular signaling pathway mediating GPR43 remains unclear. Here, we show that β-arrestin 2 mediates internalization of by agonist. Agonism reduced phosphorylation nuclear translocation factor-κB (NF-κB), which was relieved short interfering RNA (siRNA) 2. Subsequently, mRNA expression proinflammatory cytokines,...
Many linear diarylpentanoids and diarylheptanoids contain a β-hydroxy ketone or 1,3-diol functionality as the structural motif. Reported herein is asymmetric synthesis of (S)-daphneolone, (S)-dihydroyashabushiketol, formal (3S,5S)-yashabushidiol B represented examples, employing readily accessible (3S)-hydroxy-5-phenylpentanoic acid. The acid was conveniently prepared by aldol addition (R)-acetyloxazolidinone with 3-phenylpropanal affording two diastereomers which were cleanly separated...
Triacylglycerol (TG) is the major form of stored energy in eukaryotic organisms and synthesized by diacylglycerol acyltransferase (DGAT) endoplasmic reticulum (ER). DGAT2, one two DGAT enzymes, barely detectable cells, even though its mRNA transcripts are maintained at considerable levels. However, little known about how DGAT2 expression altered protein stability. was highly unstable cells rapidly degraded proteasomes an ubiquitin-dependent manner. Deletion mutation analysis identified...
Diacylglycerol acyltransferase 2 (DGAT2) is one of two distinct DGAT enzymes that catalyze the last step in triacylglycerol (TG) synthesis. Findings from previous studies suggest inhibition DGAT2 a promising strategy for treatment hepatic steatosis and insulin resistance. Here, we identified compound 122 as potent selective inhibitor human DGAT2, which appeared to act competitively against oleoyl-CoA vitro. The was also confirmed by reductions enzymatic activity de novo TG synthesis...
Idiopathic pulmonary fibrosis (IPF) is a chronic and refractory interstitial lung disease. Although there are two approved drugs for IPF, they were not able to completely cure the Therefore, development of new required effective treatment IPF. In this study, we investigated effect theophylline, which has long been used asthma, on fibrosis. The administration theophylline attenuated fibrotic changes tissues improved mechanical functions in bleomycin (BLM)-induced Theophylline suppressed IL-17...
Picroside II isolated from Pseudolysimachion rotundum var. subintegrum has been used as traditional medicine to treat inflammatory diseases. In this study, we assessed whether picroside inhibitory effects on airway inflammation in a mouse model of house dust mite (HDM)-induced asthma. the HDM-induced asthmatic model, significantly reduced cell counts bronchoalveolar lavage fluid (BALF), levels total immunoglobulin (Ig) E and HDM-specific IgE IgG1 serum, inflammation, mucus hypersecretion...
Natural killer (NK) cells are innate immune effector that protect against cancer and some viral infections. Until recently, most studies have investigated the molecular signatures of human or mouse NK to identify genes specifically expressed during cell development. However, mechanism regulating development remains unclear. Here, we report a regulatory network potential interactions in vitro differentiation cells, identified using genome-wide mRNA miRNA databases through hierarchical...
Abstract The emergence of multi-drug resistant bacteria forces the therapeutic world into a position, where development new and alternative kind antibiotics is highly important. Herein, we report triazine-based amphiphilic small molecular antibacterial agents as mimics lysine- arginine-based cationic peptide (CPAs). These compounds were screened against panel both Gram-positive Gram-negative bacterial strains. Further, anti-inflammatory evaluation these led to identification four efficient...
Idiopathic pulmonary fibrosis (IPF) is a refractory interstitial lung disease for which there no effective treatment. Although the pathogenesis of IPF not fully understood, TGF-β and epithelial–mesenchymal transition (EMT) have been shown to be involved in fibrotic changes tissues. Kurarinone prenylated flavonoid isolated from Sophora Flavescens with antioxidant anti-inflammatory properties. In this study, we investigated effect kurarinone on fibrosis. suppressed TGF-β-induced EMT epithelial...
Abstract The commitment of naive T cells to polarized Th requires specific changes in their transcription factors. Retrovirally overexpressed GATA-3 has been reported induce the Th2 cytokine profile developing Th1 cells. In this study, we examined role N-terminal finger (Nf) cell development. Nf, as well C-terminal and transactivation domain, is critical for induction phenotype. Using GATA-3-Nf a bait, our yeast two-hybrid screening identified friend GATA (FOG) cell-specific library. Naive...
The 2 adrenergic receptor (ADRB2) is a G protein-coupled transmembrane expressed in the human respiratory tract and widely recognized as pharmacological target for treatments of asthma chronic obstructive pulmonary disorder (COPD).Although number ADRB2 agonists have been developed use therapy, indacaterol only ultra-long-acting inhaled -agonist (LA-BA) approved by FDA relieving symptoms COPD patients. 1 precise molecular mechanism underlying effect indacaterol, however, remains...
The flower buds of Magnolia fargesii, known traditionally as Xinyi, exert anti-inflammatory effects against inflammatory lung diseases such chronic obstructive pulmonary disease (COPD). Lignans isolated from Xinyi are an important group plant-derived compounds. However, the mechanisms action underlying their protective COPD not yet fully understood. Here, we showed that seven lignans (lignans 1-7) obtained a CHCl3 fraction effectively suppress response in cigarette smoke condensate...
Abstract Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) plays an important role in lung cancer progression. Here, we examined the therapeutic efficacy of CEACAM6 gene silencing using siRNA delivery platform targeting acidic tumour microenvironment a adenocarcinoma xenograft mouse model. An vector was constructed by tethering peptide nucleic acid form (siCEACAM6) to with low pH-induced transmembrane structure (pHLIP) transport siRNAs across plasma membrane. Specific...
Acacetin 7-O-β-D-glucoside (tilianin) is a major constituent of Agastache rugosa, traditional medicine that has long been used for the treatment gastrointestinal disorders. Tilianin wide variety pharmacological properties such as cardioprotective, neuroprotective, and anti-atherogenic activities. We recently discovered tilianin ability to suppress MUC5AC expression in vitro. In addition, we have established an vivo model allergic asthma using house dust mite (HDM) can be applied tilianin.
Allergic asthma causes morbidity in many subjects, and novel precision-directed treatments would be valuable.We sought to examine the role of a innate molecule, repulsive guidance molecule b (RGMb), murine models allergic asthma.In using ovalbumin or cockroach allergen, mice were treated with anti-RGMb control mAb examined for airway inflammation hyperreactivity (AHR), cardinal feature asthma. The mechanisms by which RGMb airways disease also examined.We found that blockade treatment...