A5032246267- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Asthma and respiratory diseases
- Metabolism, Diabetes, and Cancer
- Ginseng Biological Effects and Applications
- Immune Cell Function and Interaction
- Phytochemicals and Antioxidant Activities
- Immune Response and Inflammation
- Lipid metabolism and biosynthesis
- Phytochemistry and Bioactive Compounds
- Sphingolipid Metabolism and Signaling
- Bioactive natural compounds
- Receptor Mechanisms and Signaling
- NF-κB Signaling Pathways
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- Pediatric health and respiratory diseases
- Histone Deacetylase Inhibitors Research
- Bone health and treatments
- Bone Metabolism and Diseases
- Cancer, Hypoxia, and Metabolism
- Essential Oils and Antimicrobial Activity
- Microbial Natural Products and Biosynthesis
- Cancer Research and Treatments
- Seaweed-derived Bioactive Compounds
Korea Research Institute of Bioscience and Biotechnology
2016-2025
Xinjiang Technical Institute of Physics & Chemistry
2008
Hanyang University Medical Center
2008
G-protein coupled receptor 43 (GPR43) serves as a for short-chain fatty acids (SCFAs), implicated in neutrophil migration and inflammatory cytokine production. However, the intracellular signaling pathway mediating GPR43 remains unclear. Here, we show that β-arrestin 2 mediates internalization of by agonist. Agonism reduced phosphorylation nuclear translocation factor-κB (NF-κB), which was relieved short interfering RNA (siRNA) 2. Subsequently, mRNA expression proinflammatory cytokines,...
Acellular bacterial ghosts (BGs) are empty non-living cell envelopes, commonly generated by controlled expression of the cloned lysis gene E bacteriophage PhiX174. In this study, Vibrio parahaemolyticus (VPGs) were chemically-induced and method is based on minimum inhibitory concentration (MIC) sodium hydroxide (NaOH), acetic acid, boric citric maleic hydrochloric sulfuric acid. The MIC values respective chemicals 3.125, 6.25, <50.0, 25.0, 1.56, 0.781 mg/mL. Except for efficiency reached...
The recently defined type of cell death ferroptosis has garnered significant attention as a potential new approach to cancer treatment owing its more immunogenic nature when compared with apoptosis. Ferroptosis is characterized by the depletion glutathione (GSH)/glutathione peroxidase-4 (GPx4) and iron-dependent lipid peroxidation. Diplacone (DP), geranylated flavonoid compound found in Paulownia tomentosa fruit, been identified have anti-inflammatory anti-radical activity. In this study,...
As part of an ongoing search for new anti-inflammatory agents from medicinal plants, five dimeric and trimeric flavonoids (1–5) were isolated the roots Pistacia weinmannifolia. The structures pistachalcone A (1), B (2), pistaflavanone (3), C (4), D (5) elucidated by analysis spectroscopic data. known compounds rhuschalcone II (6), VI (7), pauferrol (8) also identified. Our in vitro found that P. weinmannifolia root extract exert effects phorbol myristate acetate (PMA)-induced NCI-H292 airway...
Abstract Background: Myeloid-derived suppressor cells (MDSCs) are a paradigmatic, immunosuppressive cell population found in the blood and tumors of people with cancer. Alternatively-activated tumor-associated macrophages (TAMs) present high numbers tumour microenvironment (TME) derived from circulating monocytes which cancer monocytic (M)-MDSC migrate into TME polarise towards macrophage phenotype. MDSCs express common myeloid marker CD33. We previously reported that anti-CD33 antibody drug...
Diacylglycerol acyltransferase 2 (DGAT2) is one of two distinct DGAT enzymes that catalyze the last step in triacylglycerol (TG) synthesis. Findings from previous studies suggest inhibition DGAT2 a promising strategy for treatment hepatic steatosis and insulin resistance. Here, we identified compound 122 as potent selective inhibitor human DGAT2, which appeared to act competitively against oleoyl-CoA vitro. The was also confirmed by reductions enzymatic activity de novo TG synthesis...
Selenoprotein is associated with a variety of serious diseases, including infectious neurodegenerative disorders, cancer and cardiovascular disease. The aim this study was to produce new transgenic (Tg) rat expressing human selenoprotein M (SelM) in order examine the protective function antioxidant status vivo. To achieve this, lineage Tg rats produced by microinjection pCMV/GFP-hSelM constructs into fertilized egg. Several conclusions can be drawn based on results present study. SelM gene...
Picroside II isolated from Pseudolysimachion rotundum var. subintegrum has been used as traditional medicine to treat inflammatory diseases. In this study, we assessed whether picroside inhibitory effects on airway inflammation in a mouse model of house dust mite (HDM)-induced asthma. the HDM-induced asthmatic model, significantly reduced cell counts bronchoalveolar lavage fluid (BALF), levels total immunoglobulin (Ig) E and HDM-specific IgE IgG1 serum, inflammation, mucus hypersecretion...
As part of an ongoing search for new natural products from medicinal plants to treat respiratory disease, six compounds, a dihydroflavonol (1) and five C-geranylated flavanones (3, 6, 8, 13, 14), 13 known compounds were isolated mature fruits Paulownia tomentosa. The structures the determined via interpretation their spectroscopic data (1D 2D NMR, UV, IR, ECD, MS). In biological activity assays with human alveolar basal epithelial cells, expression TNF-α-induced proinflammatory cytokines...
Asthma is a chronic inflammatory lung disease that causes respiratory difficulties. Black ginseng extract (BGE) has preventative effects on diseases such as asthma. However, the pharmacological mechanisms behind anti-asthmatic activity of BGE remain unknown. To investigate mechanism BGE, phorbol 12-myristate 13-acetate plus ionomycin (PMA/Iono)-stimulated mouse EL4 cells and ovalbumin (OVA)-induced mice with allergic airway inflammation were used. Immune (eosinophils/macrophages),...
Natural killer (NK) cells are innate immune effector that protect against cancer and some viral infections. Until recently, most studies have investigated the molecular signatures of human or mouse NK to identify genes specifically expressed during cell development. However, mechanism regulating development remains unclear. Here, we report a regulatory network potential interactions in vitro differentiation cells, identified using genome-wide mRNA miRNA databases through hierarchical...
The 2 adrenergic receptor (ADRB2) is a G protein-coupled transmembrane expressed in the human respiratory tract and widely recognized as pharmacological target for treatments of asthma chronic obstructive pulmonary disorder (COPD).Although number ADRB2 agonists have been developed use therapy, indacaterol only ultra-long-acting inhaled -agonist (LA-BA) approved by FDA relieving symptoms COPD patients. 1 precise molecular mechanism underlying effect indacaterol, however, remains...
Cigarette smoke (CS) is a risk factor that can induce airway enlargement, obstruction, and mucus hypersecretion. Although studies have shown Korean black ginseng extract (BGE) has potent anti-inflammatory antioxidant activities, the CS-induced inflammatory responses molecular mechanisms are yet to be examined. The aim of this study was examine effect BGE on response its mechanisms, using CS/lipopolysaccharides (LPS)-exposed animals PMA-stimulated human epithelial NCI-H292 cells. results show...
Cigarette smoke (CS) is considered a principal cause of chronic obstructive pulmonary disease (COPD) and associated with mucus hypersecretion airway inflammation. Ginsenoside compound K (CK), product ginsenoside metabolism, has various biological activities. Studies on the effects CK for treatment COPD hypersecretion, including underlying signaling mechanism, have not yet been conducted.To study protective molecular mechanism CK, phorbol 12-myristate 13-acetate (PMA)-induced human epithelial...