A5003890945- Genetic and phenotypic traits in livestock
- Genetic diversity and population structure
- Nutrition, Genetics, and Disease
- Genetic Mapping and Diversity in Plants and Animals
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Meat and Animal Product Quality
- Agriculture and Biological Studies
- Animal Diversity and Health Studies
- Identification and Quantification in Food
- Chromosomal and Genetic Variations
- Nitrogen and Sulfur Effects on Brassica
- BRCA gene mutations in cancer
- Molecular Biology Techniques and Applications
- Wheat and Barley Genetics and Pathology
- Genetic Associations and Epidemiology
- DNA Repair Mechanisms
- Plant Disease Resistance and Genetics
- Human-Animal Interaction Studies
- Cancer-related molecular mechanisms research
- Food Industry and Aquatic Biology
- Human Health and Disease
- Animal Virus Infections Studies
- Glutathione Transferases and Polymorphisms
- Animal Nutrition and Health
Institute of Genetics and Cytology of the National Academy of Sciences of Belarus
2019-2025
International Sakharov Environmental Institute
2011-2018
Republican Scientific and Practical Center of Cardiology
2016-2017
Objective . To conduct molecular genetic studies of patients with myocardial infarction (MI) for polymorphisms genes associated the metabolism antithrombotic drugs, and to evaluate their relationship clinical laboratory parameters. Materials methods The material was venous blood acute MI who underwent percutaneous coronary intervention (PCI) stenting infarct-related artery. This data sample included 69 patients, which 58 (84.1%) were male 11 (15.9%) female. technology based on competitive...
A high differentiating potential of seven polymorphic variants has been identified to distinguish between Yorkshire, Belarusian Large White and Meat pig breeds bred in Belarus. For the Yorkshire breed, a model is proposed including three single nucleotide polymorphisms – Chr.6:g.121005974A>G, Chr.17:g.15827832G>T, Chr.10:g.30081932A>G; for breed Chr.3:g.118879246C>G, Chr.7:g.52269732A>G; Chr.8:g.47482649G>T, Chr.9:g.48882095A>G, Chr.10:g.30081932A>G. The models...
A universal methodological approach has been developed that allows solving the problem of differentiating closely related species using raw NGS sequencing data. The method is based on use single nucleotide polymorphisms (SNPs). This universal; it can be used in bioinformatic analysis results, regardless biological under study. we automating process searching for sequences flanking desired allele. search carried out researcher's personal computer, does not require expensive equipment, Python...
A panel comprising 16 short tandem repeats (STRs) and a gender-specific amelogenin marker was worked out tested for robustness in discrimination between wild domestic swine subspecies encountered Europe, regional populations of boars main breeds pigs reared Belarus. The STR dataset comprised 310 boars, inhabiting all administrative regions Belarus, 313 pigs, representing three local cosmopolitan lines. Additionally, total 835 were genotyped the presence melanocortin 1 receptor (MC1R) alleles...
The aim was to ascertain the genetic and geographical structure of Kyrgyz mountain merino (KMM). We analyzed DNA samples 109 specimens, bred in three state breeding factories (STB), including "Orgochor" Issykul Province, "Katta-Taldyk" Osh Province STb named after Luschikhin Talas Province. identified 126 alleles 12 microsatellite markers (McM042, INRA006, McM527, ETH152, CSRD247, OarFCB20, INRA172, INRA063, MAF065, MAF214, INRA005, INRA023). There were 6 16 each locus (mean 10.500 ± 0.957...
Determining the purebredity of farm animals in a breeding system is key importance for entire livestock industry. Purebred plant breeds designed to ensure production high-value improving material commercial breeding. Determination pigs can be carried out using single nucleotide polymorphisms (SNP). The multiplexing technology today has reached level that makes it possible characterize tens and hundreds thousands polymorphic variants simultaneously one run device. For first time,...
Кыргызская лошадь - уникальная горная порода, приспособленная к существованию в жестких условиях высокогорья Кыргызстана. Целью исследования было изучение особенностей генетической структуры кыргызской породы лошадей с использованием 17 микросателлитных маркеров ДНК. Установлено, что характеризуется высоким уровнем вариабельности. Kyrgyz horse is a unique breed of mountain horses adapted to living in hard conditions high mountains Kyrgyzstan. The aim I the study was investigate genetic...
Using the methods of bioinformatics, analysis data on sequencing genomes individuals species Sus scrofa domesticus , which are located in Sequence Read Archive (NCBI-SRA) database, was carried out. Genotypes were determined silico for five breeds domestic pigs – Duroc, Landrace, Pietrain, Large White and Yorkshire using an algorithm developed Python programming language. Based a two-stage bioinformatics analysis, wide range SNPs with high potential differentiation identified. The results...
Our research focused on the selection of already known markers, as well search for other informative markers based data made publicly available GEO NCBI platform (genome-wide DNA methylation projects using Infinium Human Methylation 450K BeadChip (Illumina ©)). The main objective study was to demonstrate that accuracy determining biological age a person in presence chronic diseases linear-dependent is comparable healthy person. Criminologists, rule, do not have information about who has left...
Background: this study describes the contribution of XRCC1, XRCC3 and PALB2 genes in genesis sporadic forms breast cancer Belarus patients. Materials Methods: included 169 patients with 185 healthy The molecular genetic analysis was performed by RFLP PAGE electrophoresis. Results: we identified genotypes high risk patient’s for PALB2, XRCC1 genes. We also discovered a statistically significant associations between GG genotype p.Q399R (XRCC1) tumor grade, TT gene presence metastases regional...
Genotyping of individuals 7 commercial breeds domestic pigs was carried out: Duroc, Landrace, Belarusian Large White, Black-and-White, meat, Pietrain and Yorkshire for the KDM3A DBX2 genes. The high breed-specific potential polymorphic loci g.58335217A>G (KDM3A gene) g.75953650G>T (DBX2 differentiation Duroc species Sus scrofa domesticus confirmed. A test model by bioinformatic assessment a total contribution two SNPs genes proposed. This has no analogues in world, its estimation...
Using the KASP technology, allelic composition of TaTGW6-A1, TaGASR7-A1, TaCKX6-D1, and TaGs3-D1 loci associated with 1000-grain weight trait was identified in 25 varieties variety accessions common wheat Belarusian foreign breeding. Annotated DNA sequences were selected for modeling synthesis primers. It demonstrated that examined genotypes had carried both favorable alleles weight, producing a negative effect on under study. Six breeding identified. They complex positively correlating...
Differentiation of closely related biological species using molecular genetic analysis is important for breeding farm animals, creating hybrid lines, maintaining the purity breeds, lines and layering. Bos grunniens taurus differentiation based on STR locus polymorphism will help maintain isolation these identify individuals. The aim this study to assess differentiating potential 15 microsatellite loci distinguish between domestic yak (B. grunniens) bred in Kalmak-Ashuu highland region...
In this study, we presented a panel of 14 microsatellite loci (MFW1, MFW2, MFW6, MFW9, MFW10, MFW11, MFW13, MFW16, MFW20, MFW24, MFW26, MFW28, MFW29 and Cid0909), with which studied the genetic structure Cyprinus carpio breed “Izobelinsky” in Republic Belarus. Four offshoots carp were included study: two mirrory (“Smes’ zerkal’naya”, “Tri prim”) scaly cheshujchataya”, “Stolin XVIII”). As result, it was found that exhibits high level in-breed variability. loci, 231 alleles identified, 62 %...