The outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2), alarmed the global community due to significant loss human lives during pandemic. However, as saying goes, every cloud has a silver lining. A positive aspect this recent pandemic been that it stimulated scientists create vaccines against SARS-CoV-2, accelerating emergence new therapeutic agents based on messenger ribonucleic acid (mRNA). Numerous mRNA products are currently in...

The successful application of messenger RNA (mRNA)-based vaccines for the prevention COVID-19 infection has drawn attention scientific community to potential clinical applications these molecules as innovative and alternative therapeutic approaches in various fields medicine. As agents, mRNAs may be advantageous due their unique biological properties – ability target virtually any genetic component cell encode proteins peptides without need transfer them nuclei cells. In addition, can...

Objective. To study the functional state of kidneys in men and women with various types cerebrovascular diseases (CVD). Material methods. The included 378 patients CVD: transient ischemic attack (TIA), stroke (ischemic hemorrhagic), chronic brain ischemia. average age was 61.4±13.0 63.8±11.8 years, respectively. excretory function assessed all participants. Results. TIA recorded 20.9% 13.4% women. Stroke verified 35.7% (56.4% 34.3% women, p<0.05). Recurrent more common (12.9%) than (6.9%,...

Systemic scleroderma (SSc) is one of the most common autoimmune diseases among women, with a peak incidence between ages 44 and 55. Rheumatology distinguishes several clinical forms SSc: diffuse, limited (localized), juvenile (onset before 16 years), overlap (mixed) forms. SSc classic heterogeneous disease wide range manifestations varied courses. The frequent initial symptom Raynaud’s syndrome, which can be either primary or secondary. onset in older adults requires thorough laboratory...

Disseminated intravascular coagulation (DIC) syndrome is a polyetiological clinical and laboratory that always secondary accompanies the course of many internal diseases. The core mechanism DIC involves pathological activation hemostatic system thrombinemia, leading to generalized microthrombosis microcirculatory disorders. Cases sudden-onset in previously healthy individuals are not described literature. Clinically, can present acute, subacute, or chronic forms. process progresses through...

The article presents a rare clinical case of systemic lupus erythematosus (SLE) in 22-year-old patient at week 33 pregnancy, complicated by ischemic stroke, secondary antiphospholipid syndrome, thrombosis the inferior vena cava and vessels lower extremities, polysegmental pneumonia. patient's medical history (September 2022) showed severe muscle weakness fever early postpartum period. examination revealed increased levels C-reactive protein (61.32 mg/L), D-dimer (8.970 mg FEU/L),...

Morbid obesity is defined as a body mass index (BMI) ≥ 40 kg/m² or BMI 35 in combination with severe obesity-related complications. This condition associated an extremely high risk of developing comorbidities. According to global statistics, the prevalence morbid ranges from 4% 8%. Presents clinical case kidney involvement patient and type 2 diabetes mellitus.

Eosinophilic granulomatosis with polyangiitis (Charge-Strauss syndrome) is an eosinophilic granulomatous disease characterized by small caliber vascular lesions and autoimmune in nature. Patients this syndrome experience weight loss, fever, arthralgias, myalgias. The most often begins respiratory tract involvement, including infectious allergic rhinitis, bronchial asthma, symmetric pulmonary infiltrates, pneumonia. In older individuals, the manifests multiple mononeuritis, asymmetric...

Aim. To study biomarkers of inflammation in overweight and obese individuals. Material methods. A total 180 people with or obesity were included. Anthropometric biochemical parameters determined all patients. The concentrations C-reactive protein (CRP), fibrinogen, interleukin (IL)-6, IL-10, tumor necrosis factor alpha (TNF-α) studied. Results. following significant correlations have been established: IL-6 — the levels central aortic pressure, systolic diastolic blood pressure (BP), heart...

The aim of the study was to summarize literature data on various types systemic vasculitis, their mechanisms development, diagnostic possibilities, and describe a clinical case. Systemic vasculitis is group diseases with heterogeneous etiology, which involve vessels different calibers, predominantly small and/or medium, manifesting as multi-organ dysfunction, difficult treat, poor prognosis. Currently, following are distinguished: large vessel vasculitis; medium variable single-organ associated...

To investigate the structural and functional characteristics of carotid vertebral arteries their relationship with tumor necrosis factor-alpha (TNF-α) levels in patients chronic non-infectious diseases (CNIDs), considering sex differences.

Essential hypertension (EH) is the most common cardiovascular disease and leading cause of chronic kidney (CKD) worldwide. The aim study was to investigate frequency nature damage in hypertension. 189 patients (69 men 120 women) with (stages I, II, III) aged 43 years older were examined. average age 61.2 ± 8.7 years. Clinical biochemical tests conducted on all patients, including red blood cell indices, C-reactive protein (CRP), lipid profile, fibrinogen, electrolytes, glucose, uric acid,...

To study a role of cystatin C in the nephrocerebral risk chronic kidney disease at initial stage disease.One hundred and twenty-eight patients (63 men 65 women) with (CKD) were examined pre-dialysis disease. All underwent complex clinical laboratory examination determination lipid spectrum, uric acid, fibrinogen, calcium C, subsequent calculation glomerular filtration rate (GFR). assess structural changes carotid arteries, ultrasound dopplerography was performed. Depending on thickness...

to study clinical-functional features of remodeling carotid arteries and its relation restructuring the left ventricle (LV) in patients with chronic glomerulonephritis at pre-dialysis stage.We examined 269 (189 men, 80 women) (CGN) aged 17-71 years, stages disease. We analyzed biochemical parameters peripheral blood determination daily proteinuria glomerular filtration rate (GFR). For identification structural changes (CA) LV we used Doppler ultrasound echocardiography.Atherosclerotic CA...

To assess the relationship between hypertriglyceridemia (THG) and left ventricular remodeling types in patients with chronic kidney disease(CKD).A total of 152 CKD from stages 1 to 3 were examined, 98 them without THG (subgroup 1) 54 THG. All assessed for parameters anthropometry, hemodynamics, lipid spectrum, uric acid, calcium, C-reactive protein (CRP), serum cystatin C measurement calculation glomerular filtration rate. The vascular stiffness (augmentation index stiffness)...

Objective assessment of the renal status, d-dimer and procalcitonin levels in patients with novel coronavirus disease (COVID-19) material methods: study included 123 diagnosed covid-19 pneumonia indices estimated glomerular filtration rate (egfr) were considered according to ckd-epi (Chronic kidney epidemiology Collaboration) mdrd (Modification Diet Disease) formulas The creatinine clearan concentration creatinine, d-dimer, determined results median interquartile egfr values 80 o (68 0;95 0)...

The aim was to ascertain the genetic and geographical structure of Kyrgyz mountain merino (KMM). We analyzed DNA samples 109 specimens, bred in three state breeding factories (STB), including "Orgochor" Issykul Province, "Katta-Taldyk" Osh Province STb named after Luschikhin Talas Province. identified 126 alleles 12 microsatellite markers (McM042, INRA006, McM527, ETH152, CSRD247, OarFCB20, INRA172, INRA063, MAF065, MAF214, INRA005, INRA023). There were 6 16 each locus (mean 10.500 ± 0.957...