A5022327399- DNA Repair Mechanisms
- Acute Myeloid Leukemia Research
- Ion channel regulation and function
- Chronic Lymphocytic Leukemia Research
- BRCA gene mutations in cancer
- Acute Lymphoblastic Leukemia research
- Hematopoietic Stem Cell Transplantation
- Carcinogens and Genotoxicity Assessment
- Electrolyte and hormonal disorders
- Ion Transport and Channel Regulation
Hofstra University
2024
Cohen Children's Medical Center
2024
Memorial Sloan Kettering Cancer Center
2023
Cornell University
2022
The epithelial Na+ channel (ENaC) is a heterotrimeric protein whose assembly, trafficking, and function are highly regulated. To better understand the biogenesis activation of channel, we quantified expression individual subunits ENaC in rat kidneys colon using calibrated Western blots. estimated abundance for three differed by an order magnitude with γENaC ∼ βENaC ≫ αENaC both organs. Transcript kidney, measured digital-drop PCR RNAseq, was similar subunits. In organs, calculated all much...
Abstract Leukocytosis is a common finding in pediatric patients, and the differential diagnosis can be broad, including benign reactive leukocytosis malignant myeloproliferative disorders. Transient abnormal myelopoiesis disorder that occurs young infants with constitutional trisomy 21 somatic GATA1 mutations. Most patients are observed, but outcomes span spectrum from spontaneous resolution to life-threatening complications. Juvenile myelomonocytic leukemia highly aggressive associated...