A5042013596- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- CAR-T cell therapy research
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- DNA Repair Mechanisms
- Polyomavirus and related diseases
- Virus-based gene therapy research
- Trace Elements in Health
- Iron Metabolism and Disorders
- Immune Cell Function and Interaction
- Renal Transplantation Outcomes and Treatments
- Hemoglobinopathies and Related Disorders
- Cancer Research and Treatments
- Hematological disorders and diagnostics
- Lymphoma Diagnosis and Treatment
- Ocular Oncology and Treatments
- Prenatal Screening and Diagnostics
- CNS Lymphoma Diagnosis and Treatment
- Brain Metastases and Treatment
- Childhood Cancer Survivors' Quality of Life
- Biomedical Ethics and Regulation
- Neutropenia and Cancer Infections
- Pneumothorax, Barotrauma, Emphysema
Memorial Sloan Kettering Cancer Center
2015-2025
University of Nebraska Medical Center
2006-2016
St. John Hospital & Medical Center
2012
University Hospital Leipzig
2009
Patients with alcoholic liver disease frequently exhibit iron overload in association increased hepatic fibrosis. Even moderate alcohol consumption elevates body stores; however, the underlying molecular mechanisms are unknown. Hepcidin, a circulatory peptide synthesized liver, is key mediator of metabolism. Ethanol metabolism significantly down-regulated both vitro and vivo hepcidin mRNA protein expression. 4-Methylpyrazole, specific inhibitor alcohol-metabolizing enzymes, abolished effects...
Alcohol reduces and iron increases liver hepcidin synthesis. This study investigates the interaction of alcohol in regulation messenger RNA (mRNA) expression animal models. Mice were administered 10% ethanol for 7 days after an iron-overloaded diet. Rats regular or ethanol-Lieber De Carli diets weeks with without carbonyl iron. Hfe(-/-) mice used as a model genetic overload. Hepcidin mRNA was determined by real-time polymerase chain reaction (PCR) northern blotting. Iron elevated decreased...
Anti-thymocyte globulin (ATG) is used in pediatric allogeneic hematopoietic cell transplantation (HCT) to prevent graft-versus-host-disease (GvHD) and graft failure (GF). Poor or delayed T-cell recovery, associated with increased mortality, the main toxicity of ATG. Model-based precision dosing ATG (MBD-ATG) minimizes while maintaining efficacy. We report updated results single-arm phase II PARACHUTE trial investigating MBD-ATG, combined real-world experience identical MBD-ATG. Consecutive...
Traditional weight-based dosing results in variable rabbit antithymocyte globulin (rATG) clearance that can delay CD4+ T-cell immune reconstitution (CD4+ IR) leading to higher mortality. In a retrospective pharmacokinetic/pharmacodynamic (PK/PD) analysis of patients undergoing their first CD34+ T-cell-depleted (TCD) allogeneic hematopoietic cell transplantation (HCT) after myeloablative conditioning with rATG, we estimated post-HCT rATG exposure as area under the curve (arbitrary unit per...
Abstract Allogeneic hematopoietic cell transplantation (HCT) remains the only cure for hematologic manifestations of Fanconi anemia (FA). We performed retrospective predictor analyses HCT outcomes in FA pediatric and young adult patients transplanted between 2007 2020 across three large referral institutions. Eighty-nine patients, 70 with bone marrow failure +/− cytogenetic abnormalities, 19 MDS/AML, were included. Five-year overall survival (OS) was 83.2% event-free (EFS) 74%. Age ≥19, HLA...
Alcohol downregulates hepcidin expression in the liver leading to an increase intestinal iron transport and storage. We have previously demonstrated that alcohol-mediated oxidative stress is involved inhibition of transcription by alcohol vivo. Kupffer cells TNF-α play a key role alcohol-induced injury. The aim this study was define their involvement regulation alcohol. were inactivated or depleted employing gadolinium chloride liposomes containing clodronate, respectively. Rats pair fed...
To evaluate outcomes and prognostic markers among children with relapsed Hodgkin lymphoma (HL) treated autologous stem cell transplant (ASCT), we conducted a retrospective analysis of 36 consecutive pediatric patients at Memorial Sloan Kettering Cancer Center from 1989 to 2013. With median follow-up 9.6 years, the 10-year overall survival (OS) event-free (EFS) were 74.1 67.1% respectively. Absence B-symptoms, chemotherapy-sensitive disease, date after 1997 each associated superior EFS [HR...
Background Patients with leukemia relapse after allogeneic hematopoietic cell transplant (HCT) have poor survival due to toxicity and disease progression. A second HCT often offers the only curative treatment. Methods We retrospectively reviewed our bi-institutional experience (MSKCC-USA; Utrecht-NL) unrelated cord blood transplantation (CBT) for treatment of post-transplant relapse. Overall (OS) event-free (EFS) were evaluated using Kaplan-Meier method, treatment-related mortality (TRM)...
Abstract Mental health and substance abuse challenges are widespread among incarcerated populations, often coupled with complicated histories of abuse, trauma, other psychological problems. Traditional treatments have largely consisted or pharmaceutical interventions. However, the implementation, effectiveness, financial burden traditional interventions led to exploration into alternative approaches. The purpose this study was evaluate effectiveness a six-week yoga intervention on body...
Busulfan is an alkylating drug routinely used in conditioning regimens for allogeneic hematopoietic cell transplantation (allo-HCT). A myeloablative regimen, including busulfan, commonly patients undergoing T-cell depletion (TCD) and allo-HCT, but data on optimal busulfan pharmacokinetic (PK) exposure this setting are limited. Between 2012 2019, PK was performed to target area under the curve between 55 66 mg × h/L over 3 days using a noncompartmental analysis model. We retrospectively...
Abstract Physical interactions between different cell types are a requirement for the initiation and maintenance of immune responses. The distribution pattern cells within tissue may result from specific cell‐cell‐interactions or random distribution. Tissue architecture, degree inflammation, frequencies cells, number contact partners, type, size as well movement time determine tissues. We developed matrix model to expected two (A B) cell‐cell‐contacts sections. predictions were compared with...
BackgroundAn association between early CD4+ recovery and survival after T-replete allogeneic Hematopoietic Cell Transplantation (HCT) in pediatric young adult patients was previously reported (Admiraal et al, JACI 2017). However, validation a separate cohort undergoing ex vivo T cell depleted (TCD) HCT is lacking. Therefore, we studied the relation immune reconstitution (IR) clinical outcomes, setting where majority of received TCD HCT.MethodsWe performed retrospective analysis data on...
This multi-institutional study was designed to optimize outcomes of alternative donor HCT in patients with FA without using total body irradiation (TBI). TBI replaced by busulfan (BU) (to reduce the risk secondary solid tumors) and BU dose reduced after first 25 find lowest acceptable dose. 45 were transplanted from June 2009 May 2014. These included prior transfusions, androgen use myelosdysplastic syndrome. Patient demographics, disease characteristics are described Table 1. Preparative...