Background Epidemiologic research suggests that gut microbiota alteration (dysbiosis) may play a role in the pathogenesis of metabolic syndrome (MetS). Dysbiosis can influence Trimethylamine N-oxide (TMAO) microbiota-derived metabolite, as well kynurenine pathways (KP), which are known new marker for an early predictor chronic diseases. Hence, current study aimed to investigate association between KYN and TMAO with MetS its components. Methods This case-control was conducted on 250 adults...

Abstract Background Caveolin-1 (CAV-1) is a cholesterol-dependent essential component located in caveolae. Several studies have been CAV-1 related to cardio-metabolic parameters animal models, however, there are few humans. Importantly, no study has investigated the interaction between rs3807992 gene and dietary patterns (DPs) on risk factors. Methods The current cross-sectional was conducted 404 overweight obese women. Dietary intake obtained from FFQ with 147 items. genotype measured by...

Obesity affects body composition and anthropometric measurements. A Body Shape Index (ABSI) Roundness (BRI) are reportedly associated with an increased risk of cardiovascular disease. However, the relationship between ABSI, BRI, cardiometabolic factors, inflammatory elements is not well-elucidated. Therefore, this study sought to examine mediatory effect markers on association ABSI BRI factors in overweight obese women. This cross-sectional was performed 394 The typical food intake...

Background Dietary nitrate and nitrite may affect the gut microbiota its metabolites, such as trimethylamine N-oxide (TMAO) kynurenine (KYN). However, this association exact mechanism are still unclear. Therefore, study aimed to assess between dietary consumption of on TMAO KYN levels in adults. Methods This cross-sectional was employed a subsample baseline phase Tehran University Medical Sciences (TUMS) Employee's Cohort Study (TEC). A total 250 adults aged 18 years or older were included...

Abstract Diabetic nephropathy (DN) is one of the most prevalent and severe complications diabetes mellitus (DM) associated with increased morbidity mortality. We aimed to investigate associations between red, processed, white meat consumption odds developing kidney damage DN in women. enrolled 105 eligible women controls (30–65 years). A validated reliable food frequency questionnaire (FFQ) was used evaluate meat. Biochemical variables anthropometric measurements were assessed for all...

Abstract Several studies have reported a significant association between the metabolic syndrome (MetS) and mortality around world. Caveolin-1 (CAV-1) has been widely studied in dyslipidaemia, several indicated that CAV-1 genetic variations may correlate with dietary intake of fatty acids. This study aimed to investigate interaction rs3807992 types acid MetS risk. cross-sectional was carried out on 404 overweight obese females. Dietary obtained from 147-item FFQ. The genotype measured using...

Diabetic nephropathy (DN) is involved in 40% of patients with type 2 diabetes, Phytochemical index (PI) foods are known as antioxidant and anti-inflammatory agents. Higher intake phytochemicals can improve glucose tolerance, hypertension complications DN. This study sought to discern the relationship between dietary PI was a case-control which conducted 210 diabetic women. General characteristics, blood pressure, biochemical serum levels, anthropometric measurements were evaluated. Physical...

Abstract Gene–diet interactions may play an important role in the inter individual diversity observed on cardiovascular disease (CVD) risk factors. Therefore, current study, we examined interaction of CETP TaqB1 polymorphism with dietary insulin index and load (DII DIL), altering CVD factors among type 2 diabetes mellitus (T2DM). In this cross-sectional blood samples were collected from 220 diabetic patients (134 females 86 male) a mean age 52.24 years Tehran, Iran. DIL DII obtained via...

Abstract Objective The increased prevalence of metabolic dyslipidemia (MD) and its association with a variety disorders raised lot attention to management. Caveolin 1 (CAV1) the key protein in caval structure plasma membranes is many cell types that play an important role function. known gene associated obesity. Today, novel diet recognized as Mediterranean Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) reported have positive effect on overall health. Hence, we aimed...

Metabolic syndrome (MetS) prevalence has increased globally.The evidence shows thatdiet and gut microbial metabolites includingtrimethylamine N-oxide (TMAO) kynurenine (KYN) play an important role in developing MetS. However, there is a lack of on associations between diet these metabolites. This study aimed to investigate the interaction dietary nitrate/nitrite (TMAO, KYN) MetS its components.

Abstract Objectives Obesity and insulin resistance (IR) are interrelated in a range of ways. The IR-obesity relationship is not cause-and-effect association. Molecular biology research has made tremendous strides discovering contributors to find this Genes that control adipocyte function such as caveolin-1 ( CAV1 ) ; probably interact the pathogenesis human IR context. involvement glucose/lipid homeostasis revealed could modify signaling receptor. We examined association between modifying...

Abstract Background Metabolic syndrome (MetS) is associated with an increased risk of morbidity and mortality in almost all chronic diseases. The most frequent methods for the calculation a continuous MetS (cMetS) score have used standardized residuals linear regression (z-score). Recently, emerging data suggest that one main genetic targets CAV1 , which plays crucial role regulating body fat distribution. This study designed to investigate relationship between rs3807992 genotypes cMetS,...

Uncontrolled diabetes can lead to diabetic nephropathy (DN). The aim of the study was investigate relationship between different dietary micronutrient patterns and risk DN in women. This a case-control study. One hundred five patients had (defined as urinary mg albumin per gram creatinine ≥30 mg/g) were chosen case 105 women without control. Dietary intakes assessed by semi-quantitative food frequency questionnaire. Principal component analysis with varimax rotation used derive patterns....

Migraine is a common brain disorder characterized by recurrent seizures lasting between 4 and 72 h. Dietary factors can affect migraine headaches. The Alternative Healthy Diet Index (AHEI) measure of diet quality adherence to healthy dietary patterns. This study aimed assess the association AHEI severity, disability, duration, frequency headaches.In this cross-sectional study, 266 women who suffered from migraines were selected. Usual intakes assessed using semi-quantitative, 147-item, food...

ApoB insertion/deletion (ins/del) genetic variant (rs11279109) is thought to be related cardio-metabolic markers and obesity. This association has the potential modified by dietary patterns. Since majority of studies concerned role acid load (DAL) or in type 2 diabetes mellitus (T2DM) its complications independently, due insufficient data regarding possible interactions between variants DAL on anthropometric metabolic markers, we aimed study interaction this along with leptin among Iranian...

Brain-derived neurotrophic factor (BDNF) belongs to the "neurotrophin" family of growth factors, and it has recently been associated cardiovascular disease (CVD). We anticipated that BDNF Val66Met polymorphisms may alter CVD risk markers such as serum lipid profile differences, interaction with total antioxidant capacity diet (DTAC) could these clinical parameters. This cross-sectional study consisted 667 diabetic patients (39.7% male 60.3% female). DTAC was calculated by international...

The present study aimed to investigate the effect of interaction between peroxisome proliferator-activated receptor gamma (PPAR-γ) Pro12Ala polymorphisms and dietary insulin load index (DIL DII) on cardio-metabolic markers among diabetic patients.This cross-sectional was conducted 393 patients. A food-frequency questionnaire used for DIL DII calculation. PPAR-γ genotyped by a polymerase chain reaction-restriction fragment length polymorphism method. Biochemical markers, including total...

A series of recent studies have indicated that the Caveolin-1 (CAV-1) gene variant may be associated with metabolic and inflammatory markers anthropometric measures. Furthermore, it has been shown a plant-based dietary index (PDI) can elicit positive impact on these markers. Therefore, we sought to examine whether PDI intakes affect relationship between CAV-1 (rs3807992) factors, as well serum measures, in women obesity. This current study consisted 400 overweight obesity, mean (SD) age...