A5037662982- Bone health and treatments
- Protein Kinase Regulation and GTPase Signaling
- Ion channel regulation and function
- Parathyroid Disorders and Treatments
- Bone Metabolism and Diseases
- Bone health and osteoporosis research
- Ion Transport and Channel Regulation
- Vitamin D Research Studies
- Metabolism, Diabetes, and Cancer
- Osteoarthritis Treatment and Mechanisms
- Receptor Mechanisms and Signaling
- PI3K/AKT/mTOR signaling in cancer
- Magnesium in Health and Disease
University of California, San Francisco
2012-2022
San Francisco VA Medical Center
2012-2021
Northern California Institute for Research and Education
2019
Physiological responses to parathyroid hormone depend on the subcellular location of receptor activity.
Abstract We studied mice with or without heterozygous deletion of the Casr in parathyroid gland (PTG) [PTGCaSR(+/–)] to delineate effects age and sex on manifestations hyperparathyroidism (HPT). In control mice, aging induced a left-shift Ca2+/parathyroid hormone (PTH) set point accompanied by increased PTG CaSR expression along lowered serum Ca2+ mildly PTH levels, suggesting adaptive responses PTGs aging-induced changes mineral homeostasis. The Ca2+/PTH were significantly blunted...
Calcium and its putative receptor (CaSR) control skeletal development by pacing chondrocyte differentiation mediating osteoblast (OB) function during endochondral bone formation-an essential process recapitulated fracture repair. Here, we delineated the role of CaSR in transition callus chondrocytes into OB lineage subsequent formation at sites explored targeting CaSRs pharmacologically to enhance In cultured from soft calluses a closed, unfixed site, extracellular [Ca2+ ] allosteric agonist...
Impaired mineral ion metabolism is a hallmark of CKD-metabolic bone disorder. It can lead to pathologic vascular calcification and associated with an increased risk cardiovascular mortality. Loss calcium-sensing receptor (CaSR) expression in smooth muscle cells exacerbates vitro. Conversely, be reduced by calcimimetics, which function as allosteric activators CaSR.To determine the role CaSR calcification, we characterized mice targeted Casr gene knockout ( SM22α Δflox/Δflox ).Vascular...