A5061751303- Genetics, Aging, and Longevity in Model Organisms
- Chemotherapy-induced organ toxicity mitigation
- Cancer-related cognitive impairment studies
- Circadian rhythm and melatonin
- Mitochondrial Function and Pathology
- Selenium in Biological Systems
- Microtubule and mitosis dynamics
- DNA Repair Mechanisms
- Biochemical Acid Research Studies
- Coenzyme Q10 studies and effects
- Sirtuins and Resveratrol in Medicine
- Sodium Intake and Health
- Light effects on plants
- Mycotoxins in Agriculture and Food
- Hormonal Regulation and Hypertension
- Trace Elements in Health
- Glioma Diagnosis and Treatment
- RNA Research and Splicing
- GDF15 and Related Biomarkers
- Seed Germination and Physiology
- Genomics, phytochemicals, and oxidative stress
- Reproductive Biology and Fertility
- Spaceflight effects on biology
- DNA and Nucleic Acid Chemistry
Heinrich Heine University Düsseldorf
2012-2024
RWTH Aachen University
2012
Myricetin is a naturally occurring flavonol found in many plant based food sources. It increases the lifespan of Caenorhabditis elegans, but molecular mechanisms are not yet fully understood. We have investigated impact this flavonoid on transcription factors DAF-16 (C. elegans FoxO homologue) and SKN-1 (Nrf2 homologue), which crucial functions regulation ageing. rapidly assimilated by nematode, causes nuclear translocation SKN-1, finally prolongs mean adult C. 32.9%. The prolongation was...
2,3,5,4′-Tetrahydroxystilbene-2-O- β -D-glucoside (TSG) was isolated from Polygonum multiflorum , a plant which is traditionally used as an anti-ageing drug. We have analysed ageing-related effects of TSG in the model organism C. elegans comparison to resveratrol. exerted high antioxidative capacity both cell-free assay and nematode. The even higher compared Presumably due its effects, treatment with decreased juglone-mediated induction enzyme SOD-3; GST-4 by juglone diminished slightly....
Statins belong to the most pre-scribed cholesterol lowering drugs in western countries. Their competitive inhibition of HMG-CoA reductase causes a reduction mevalonate pool, resulting reduced biosynthesis, impaired protein prenylation and glycosylation. Recently, cohort study showed decreased mortality rate humans between age 78-90 going along with statin therapy, which is independent blood levels. As
Only certain flavonoids have been shown to enhance life span. This was pointed out for e.g. myricetin in the nematode Caenorhabditis elegans. However, structural requirements responsible this effect are not known. We used methylated derivatives of (laricitrin, syringetin, myricetintrimethylether) investigate if free OH moieties B-ring necessary span extending effect. In analogy myricetin, all increased span, decreased oxidative stress (DCF) and accumulation lipofuscin. contrast compounds...
The planar cell polarity (PCP) pathway is highly conserved from Drosophila to humans and a PCP-like has recently been described in the nematode Caenorhabditis elegans. developmental function of this coordinate orientation cells or structures within plane an epithelium organize cell-cell intercalation required for correct morphogenesis. Here, we describe novel role VANG-1, only C. elegans ortholog PCP component Strabismus/Van Gogh. We show that two alleles vang-1 depletion protein by RNAi...
Cisplatin and derivatives are commonly used as chemotherapeutic agents. Although the cytotoxic action of cisplatin on cancer cells is very efficient, clinical oncologists need to deal with two major difficulties: (i) onset resistance drug, (ii) effect in patients. Here we use Caenorhabditis elegans investigate factors influencing response multicellular organisms. In this hermaphroditic model organism, observed that sperm failure a cause cisplatin-induced infertility. RNA-seq data indicate...
Cisplatin is the most common drug in first-line chemotherapy against solid tumors. We and others have previously used nematode Caenorhabditis elegans to identify genetic factors influencing sensitivity resistance cisplatin. In this study, we C. explore cisplatin effects on mitochondrial functions investigate cisplatin-induced neurotoxicity through a high-resolution system for evaluating locomotion. First, report that high-glucose diet sensitizes at physiological level CED-13 protects cell...
Cisplatin not only targets DNA but also RNA. However, it is largely unknown whether platinated RNA (Pt-RNA) causes apoptosis and thus contributes to the cytotoxic effects of cisplatin. Consequently, cellular was isolated from HepG2 LS180 cells, exposed cisplatin, resulting Pt-RNA (20 ng Pt/µg RNA) transfected into these cancer cell lines or used treat an reporter Caenorhabditis elegans (C. elegans) strain (MD701, expressing CED-1::GFP). Cellular molecular were evaluated by luminogenic...
ABSTRACT Cisplatin and derivatives are commonly used as chemotherapeutic agents. Although the cytotoxic action of cisplatin on cancer cells is very efficient, clinical oncologists need to deal with two major difficulties: (i) onset resistance drug, (ii) effect in patients. Here we use Caenorhabditis elegans investigate factors influencing response multicellular organisms. In this hermaphroditic model organism, observed that sperm failure a cause cisplatin-induced infertility. RNA-seq data...
ABSTRACT Cisplatin is the most common drug in first-line chemotherapy against solid tumors. We and others have previously used nematode Caenorhabditis elegans to identify genetic factors influencing sensitivity resistance cisplatin. In this study, we take advantage of C. explore cisplatin effects on mitochondrial functions investigate cisplatin-induced neurotoxicity through a high-resolution semi-automated system for evaluating locomotion. Firstly, report that high-glucose diet sensitizes at...