A5070315010- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Diet, Metabolism, and Disease
- Proteins in Food Systems
- Phytochemicals and Antioxidant Activities
- Gout, Hyperuricemia, Uric Acid
- Natural product bioactivities and synthesis
- Genomics, phytochemicals, and oxidative stress
- Pharmacological Effects of Natural Compounds
- Phytochemistry and Biological Activities
- Natural Antidiabetic Agents Studies
- Ginseng Biological Effects and Applications
- Acne and Rosacea Treatments and Effects
- Retinal Diseases and Treatments
- Protein Hydrolysis and Bioactive Peptides
- Food composition and properties
- Cholesterol and Lipid Metabolism
- Nuts composition and effects
- Synthesis and Biological Evaluation
- Glycosylation and Glycoproteins Research
- Phytase and its Applications
- Metabolomics and Mass Spectrometry Studies
- Chromatography in Natural Products
- Computational Drug Discovery Methods
- Antioxidant Activity and Oxidative Stress
Beijing Technology and Business University
2019-2025
Shandong University
2024
Shandong Provincial Hospital
2024
Shandong First Medical University
2024
First Affiliated Hospital of Xinjiang Medical University
2024
Xinjiang Medical University
2024
China Agricultural University
2014-2023
Shanghai Clinical Research Center
2021-2023
Shanghai University
2021-2023
Northeast Normal University
2023
Background: Insulin resistance (IR) affects the development of type 2 diabetes mellitus (T2DM), which is also influenced by accumulated fine particle air pollution [particulate matter (PM) with aerodynamic diameter <2.5μm (PM2.5)] exposure. Previous experimental and epidemiological studies have proposed several potential mechanisms PM2.5 contributes to IR/T2DM, including inflammation imbalance, oxidative stress, endothelial dysfunction. Recent evidence suggests that imbalance gut microbiota...
Background The high morbidity of metabolic dysfunction diseases has heightened interest in seeking natural and safe compounds to maintain optimal health. γ-Oryzanol (OZ), the ferulic acid (FA) ester with phytosterols, mainly present rice bran been shown improve markers syndrome. This study investigates effects FA OZ on alleviating high-fat high-fructose diet (HFFD)-induced syndrome parameters. Methods Male SD rats were fed a regular rodent diet, HFFD, or HFFD supplemented 0.05% 0.16%...
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in world. However, current biomarkers that discriminate HCC from liver cirrhosis (LC) are important but limited. More reliable for diagnosis therefore needed. Serum patients, LC patients and healthy volunteers were analyzed using NMR LC/MS-based approach conjunction with random forest (RF) analysis to their serum metabolic profiles. Thirty-two potential have been identified, feasibility these was evaluated, where 100%...
This study aimed to investigate the protective effect of genistein or puerarin on chronic alcohol-induced liver injury in vivo and explore underlying mechanisms hepatoprotective effects. Mice were administered (0.3 mmol kg(-1) body weight) gastrically infused with 50% alcohol once per day for 5 weeks. Levels serum transaminases, hepatic lipids, antioxidant capacities, inflammation, apoptosis, histopathological sections analyzed. Results showed that exhibited similar effects ameliorating...
Scope Cyanidin‐3‐glucoside (C3G) is a major anthocyanin in berries and potential nutritional supplement for preventing retinal degeneration. However, the protective mechanism of C3G its metabolites, protocatechuic acid (PCA) ferulic (FA), remain unclear. The molecular mechanisms metabolites against photooxidative damage vivo are investigated. Methods results Pigmented rabbits were orally administered C3G, PCA, FA (0.11 mmol/kg/day) 3 weeks. Electroretinography, histological analysis, TUNEL...
Excessive visible light exposure can induce damage to retinal cells and contribute the development or progression of age-related macular degeneration. In this study we created a model phototoxicity in pigmented rabbits. Furthermore, investigated protective effect bilberry anthocyanin extract (BAE, Table A1) explored possible mechanisms action model. The light-induced was established by rabbits exposed at 18,000 lx for 2 h, they were sacrificed on day 7. After administration BAE dosages 250...
Alcoholic liver disease (ALD) has become one of the major global health problems, with augmented morbidity and mortality. Evidence indicates that flavonoids can reduce risk ALD owing to their biological properties. However, effect structurally different flavonoid subclasses on alleviating alcohol-induced damage in a same model never been studied. In this study, mice were supplemented five kinds subgroups, apigenin (flavone), quercetin (flavonol), naringenin (flavanone), (-)-epigallocatechin...
Bee pollen (BP) is collected by honeybees from flower mixed with nectar and its secretions extensive nutritional therapeutic properties. Lipids are known to be critical contributors for the effects of BP vary depending on different plant sources; however, lipid profiles not available. Here, an UPLC-Q-Exactive Orbitrap/MS method was established comprehensive lipidomics analysis derived three major plants (Brassica campestris L., Camellia sinensis Nelumbo nucifera Gaertn.). A total nine...
Astragalus, a medical and edible plant in China, shows several bioactive properties. However, the role of astragalus attenuating alcoholic liver disease (ALD) is less clear. The objective this project to investigate improving effect saponins (AS) polysaccharides (AP), which are two primary constituents on hepatic injury induced by alcohol, potential mechanisms action. Different doses AS (50 100 mg/kg bw) AP (300 600 were orally given alcohol-treated mice for four weeks. results demonstrated...
Purpose: Due to a lack of recognized molecular targets for therapy, patients with triple-negative breast cancer (TNBC), unlike other subtypes cancers, generally have not benefited from the advances made targeted agents. The CXCR4/SDF-1 axis is involved in tumor growth and metastasis TNBC. Therefore, down-regulation expression CXCR4 cells potential therapeutic strategy inhibiting primary In order identify bioactive compounds that inhibit traditional Chinese medicines, we investigated capacity...
Ellagic acid, a natural polyphenolic compound commonly present in vegetables, fruits, nuts, and other edible plants, exerts many pharmacological activities. The project was designed to explore the hepatoprotective effect of ellagic acid against alcohol-induced liver disease (ALD) correlation among alcohol, oxidative stress, inflammation, gut microbiota. Fifty percent (v/v) alcohol (10 mL/kg bw daily) orally administrated for 4 weeks mice along with (50 100 mg/kg bw). Alcohol administration...
STVRE has strong potential in combating HUA through following possible mechanisms; (1), inhibited XOD enzyme (2), exhibited uricosuric effect, (3) improved UA mediated oxidative stress, (4) remarkably reduced renal inflammation caused by UA.
The occurrence of 187 pharmaceuticals and personal care products (PPCPs) was investigated in bottled water samples (35 33 from Chinese foreign brands, respectively). Forty-four compounds belonging to 14 PPCP categories were detected 56 the 68 samples. Further, more than 35% contained at least three PPCPs, one particular sample, 11 different PPCPs detected. Macrolides constituted most prevalent category, salbutamol, erythromycin, azithromycin showed highest detection frequency (17.6%)....
Ferulic acid could promote uric excretion in the kidneys and intestine to ameliorate high-fructose/fat diet-induced hyperuricemia alleviate its associated renal impairment intestinal microbiota disorder.
Metabolic syndrome is a serious health problem worldwide. Increasing evidence indicates that flavonoid-rich foods exert beneficial effects. However, the function of flavonoids in metabolic controversial. Here, we focus on structural effects by comparing effect five purified subclasses high-fat and high-fructose diet (HFFD) induced vivo. Sprague–Dawley (SD) rats were fed with (i) basal (3.21 kcal/g) (ii) HFFD (25% lard 25% fructose, 4.70 kcal/g), (iii) representing different (2.6 mmol/kg...
Limited information is available regarding the relationship between chemical structures and inhibitory effects of anthocyanin (ACN) on triglyceride (TG) overaccumulation. Thus this study investigated antioxidant activity effect blackberry, wild blueberry, strawberry, chokeberry ACN-rich extracts, with different structural characteristics, oleic acid-induced hepatic steatosis in vitro. Four major ACNs from these berries, aglycones, namely cyanidin-3-glucoside (Cy-3-glu),...
2,3,5,4′-Tetrahydroxystilbene-2-O- β -D-glucoside (TSG) was isolated from Polygonum multiflorum , a plant which is traditionally used as an anti-ageing drug. We have analysed ageing-related effects of TSG in the model organism C. elegans comparison to resveratrol. exerted high antioxidative capacity both cell-free assay and nematode. The even higher compared Presumably due its effects, treatment with decreased juglone-mediated induction enzyme SOD-3; GST-4 by juglone diminished slightly....