A5059498013- Alkaline Phosphatase Research Studies
- Corporate Governance and Management
- Heterotopic Ossification and Related Conditions
- Biochemical and Molecular Research
- Physiological and biochemical adaptations
- Erythrocyte Function and Pathophysiology
- Bone health and treatments
- Vitamin D Research Studies
- Bone and Dental Protein Studies
- Bone and Joint Diseases
- Bone health and osteoporosis research
- Muscle and Compartmental Disorders
- Corporate Governance and Law
- Pregnancy and preeclampsia studies
- Atrial Fibrillation Management and Outcomes
- RNA modifications and cancer
- Protein Tyrosine Phosphatases
- Cellular Mechanics and Interactions
- Anesthesia and Neurotoxicity Research
- Radiopharmaceutical Chemistry and Applications
- Optical Imaging and Spectroscopy Techniques
- Acute Ischemic Stroke Management
- Microtubule and mitosis dynamics
- Selenium in Biological Systems
University of Würzburg
2013-2022
Charité - Universitätsmedizin Berlin
2013
Orthopedic Center
2012
AimsCerebral and microvascular perfusion is reduced in atrial fibrillation (AF). Maintenance of brain important acute disease long-term course. Assessment oxygenation difficult clinical practice. Our study aimed to determine changes cerebral tissue oxygen saturation (SctO2) with bedside near-infrared spectroscopy (NIRS).
Anti-resorptive bisphosphonates (BP) are used for the treatment of osteoporosis and bone metastases. Clinical studies indicated a benefit in survival tumor relapse subpopulations breast cancer patients receiving zoledronic acid, thus stimulating debate about its anti-tumor activity. Amino-bisphosphonates nM concentrations inhibit farnesyl pyrophosphate synthase leading to accumulation isopentenyl (IPP) ATP/pyrophosphate adduct ApppI, which induces apoptosis osteoclasts. For effects μM needed...
Hypophosphatasia (HPP) is a rare genetic disease with diverse symptoms and heterogeneous severity of onset underlying mutations in the ALPL gene encoding ectoenzyme Tissue-nonspecific alkaline phosphatase (TNAP). Considering establishment zebrafish (Danio rerio) as new model organism for HPP, aim study was spatial temporal analysis alpl expression embryos adult brains. Additionally, we determined functional consequences Tnap inhibition on neural skeletal development zebrafish. We show that...
Mineralization disorders with a broad range of etiological factors represent huge challenge in dental diagnosis and therapy. Hypophosphatasia (HPP) belongs to the rare diseases affecting predominantly mineralized tissues, bones teeth, occurs due mutations ALPL gene, which encodes tissue-nonspecific alkaline phosphatase (TNAP). Here we analyzed stem cells from bone marrow (BMSCs), pulp (DPSCs) periodontal ligament (PDLSCs) absence presence efficient TNAP inhibitors. The differentiation...
Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)
Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)
Hypophosphatasia (HPP) is a rare hereditary disease due to mutations in the tissue-nonspecific alkaline phosphatase (TNAP) gene. HPP leads severe dental and bone mineralization issues, craniosynostosis, neurological disorders like epileptic seizures, anxiety, depression. We established zebrafish (Danio rerio) as vivo model system for detailed investigations visualization of tissue-specific effects context craniosynostosis neuronal symptoms HPP.
Introduction Hypophosphatasia (HPP) is a rare inherited disorder caused by compound- or dominant negative heterozygous loss-of-function mutations in the ALPL gene encoding Tissue- Nonspecific Alkaline Phosphatase (TNAP). Besides skeletal symptoms, some patients also present dental abnormalities, like for example premature loss of deciduous teeth without prior root resorption.