A5009129479- Sociology and Education Studies
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Helicobacter pylori-related gastroenterology studies
- Global Peace and Security Dynamics
- Social Policies and Healthcare Reform
- Education Methods and Technologies
- Social and Demographic Issues in Germany
- Inflammatory Bowel Disease
- IL-33, ST2, and ILC Pathways
- International Labor and Employment Law
- Escherichia coli research studies
- Vocational Education and Training
- Microscopic Colitis
- Eosinophilic Esophagitis
- Retinoids in leukemia and cellular processes
- Mycobacterium research and diagnosis
- Labor Movements and Unions
- Peacebuilding and International Security
- Digestive system and related health
- Liver Disease Diagnosis and Treatment
- European Law and Migration
- Legal Issues in South Africa
- T-cell and B-cell Immunology
- Linguistic Education and Pedagogy
University of Applied Sciences Landshut
2025
Alfred-Wegener-Institut Helmholtz-Zentrum für Polar- und Meeresforschung
2023
University of Teacher Education in Special Needs
2010-2022
Bielefeld University
2022
University of Regensburg
2006-2019
European University Viadrina
2019
Ludwig-Maximilians-Universität München
2019
Max Planck Institute for Social Anthropology
2016
Max Planck Society
2016
University Hospital Regensburg
2006-2015
Liver cirrhosis is associated with bacterial translocation (BT) and endotoxemia. Most translocating bacteria belong to the common intestinal microbiota, suggesting a breakdown of barrier function. We hypothesized that diminished mucosal antimicrobial host defense could predispose BT. Two rodent models portal hypertension increased BT were used, CCl(4)-induced ascitic 2-day vein-ligated (PVL) animals. was assessed by standard microbiological techniques on mesenteric lymph nodes. Total RNA...
Despite therapeutic advances multiple myeloma remains largely incurable, and novel concepts are needed. The Hsp90-chaperone is a reasonable target, because it maintains oncogenic signaling of deregulated pathways. However, in contrast to promising preclinical results, only limited clinical efficacy has been achieved through pharmacological Hsp90 inhibition. Because Hsp70 described interact functionally with the Hsp90-complex, we analyzed suitability Hsp72 Hsp73 as potential additional target...
Interleukin-33 (IL-33) is a member of the IL-1 family. Recent evidence shows importance IL-33 in autoimmune and inflammatory diseases. To elucidate its impact on bowel disease we studied effects exogenous during induction acute dextran sodium sulfate (DSS)-induced colitis, period chronic DSS after establishment inflammation.For colitis mice received their drinking water for 7 days were killed at day 8 or 14 first administration. Chronic was induced by four cycles DSS. Animals treated with...
IFN-α is an antineoplastic agent in the treatment of several solid and hematologic malignancies that exerts strong immune- autoimmune-stimulating activity. However, mechanisms immune activation by remain incompletely understood, particularly with regard to CD4(+)CD25(high)Foxp(+) regulatory T cells (Treg). Here, we show deactivates suppressive function human Treg downregulating their intracellular cAMP level. IFN-α-mediated inactivation increased CD4(+) effector T-cell natural killer cell...
The adipokine CTRP-3 (C1q/TNF-related protein-3) belongs to the C1q/TNF-related protein family which antagonizes effects of lipopolysaccharide (LPS). aim was investigate antiinflammatory and antifibrotic role in Crohn's disease (CD).Mesenteric adipose tissue (MAT) patients with CD or colonic cancer (CC) resected. Human primary lamina propria fibroblasts (CLPF) were isolated from controls patients. Concentrations chemokines cytokines supernatants measured by enzyme-linked immunosorbent assay...
The Marine Stations Helgoland and Sylt are permanent coastal stations in the German Bight operated as one joint research infrastructure by Alfred Wegener Institute Helmholtz Centre for Polar Research (AWI). Using both stations, south-west region of North Sea its ecosystem features tightly monitored via ecological time series, which recorded made available to government offices, professional associations, institutes world-wide. a hub national transnational access guest researchers visiting...
AIM:To investigate the effects of transforming growth factor β1 (TGF-β1) on differentiation colonic lamina propria fibroblasts (CLPF) into myofibroblasts in vitro . METHODS:Primary CLPF cultures were incubated with TGF-β1 and analyzed for production α-smooth muscle actin (α-SMA), fibronectin (FN) FN isoforms.Migration assays performed a modified 48-well Boyden chamber.Levels total phosphorylated focal adhesion kinase (FAK) after induction migration.RESULTS: Incubation 2 d did not change...
The single nucleotide polymorphism (SNP) rs2542151 within the gene locus region encoding protein tyrosine phosphatase non-receptor type 2 (PTPN2) has been associated with Crohn's disease (CD), ulcerative colitis (UC), type-I diabetes, and rheumatoid arthritis. We have previously shown that PTPN2 regulates mitogen-activated kinase (MAPK) signaling cytokine secretion in human THP-1 monocytes intestinal epithelial cells (IEC). Here, we studied whether intronic SNP rs1893217 immune responses to...
Abstract Bilberries have positive effects in acute and chronic diarrhea. Patients with inflammatory bowel disease (IBD) report on improved symptoms upon ingestion. contain approximately 10% of anthocyanins (ACs), which anti‐oxidative, anti‐carcinogenic, anti‐inflammatory properties. We investigated whether experimental colitis can be ameliorated by dried bilberries or ACs. Acute dextrane sodium sulphate (DSS) were induced Balb/c mice 2.5% DSS the drinking water. Mice fed ACs, respectively....
Abstract Armed actors dominate contemporary conflict environments dramatically. Their degree of dispersion, influence, and effect on international politics make it necessary to establish strategies for interaction with them. This article makes a contribution by assessing particular their suitability applicability regard specific actors. First, delineates options dealing armed based three perspectives from relations theory: realist, institutionalist, constructivist. Second, matches these the...
A disturbed regulation of Toll-like receptor (TLR) signal transduction resulting in the exclusive activation proinflammatory signaling pathways may be critical for perpetuation established chronic colitis. Glycogen synthase kinase 3-β (GSK3-β) was recently identified as an important regulator TLR mediating excessive inflammatory responses. The aim this study to assess role GSK3-β activity intestinal inflammation.Chronic colitis induced by dextran sodium sulfate (DSS) treatment. Mice were...
Dihydroorotate dehydrogenase (DHODH) is a key enzyme involved in pyrimidine biosynthesis. DHODH known target for the treatment of autoimmune diseases. 4SC-101 novel immunosuppressive drug that inhibits DHODH. A goal our study was to examine vitro effects on IL-17 production by mononuclear cells. In addition, we evaluated efficacy against acute TNBS (2,4,6-tritrobenzene sulfonic acid) and chronic dextran sodium sulfate (DSS)-induced colitis mice.Peripheral blood cells (PBMCs) from healthy...
BCL-2 modifying factor (BMF) is a sentinel considered to register damage at the cytoskeleton and convey death signal B-cell lymphoma 2. 2 neutralized by BMF thereby facilitates cytochrome C release from mitochondria. We investigated role of for intestinal epithelial cell (IEC) homeostasis. Acute colitis was induced in Bmf-deficient mice (Bmf(-/-)) with dextran sulfate sodium. Colonic crypt length Bmf(-/-) significantly increased as compared WT mice. Dextran sodium less signs mice, weight...
Abstract Due to climate change and global warming, sustainable consumption—as one possible solution these challenges—is becoming more relevant. One generation that is affected the most by developments are millennials. While baby boomers retiring, millennials now transitioning from being in training full-time employed, which marks a big their lives makes understanding values consumption behaviour important for marketers. The goal of our study clarify influence building attitude millennials,...
Dietary lipids or pharmacologic modulation of lipid metabolism are potential therapeutic strategies in inflammatory bowel disease (IBD). Therefore, we analysed alterations bioactive experimental models colitis and examined the functional consequence second messenger ceramide pathways leading to tissue destruction.