A5027781118- Bone Tissue Engineering Materials
- Calcium Carbonate Crystallization and Inhibition
- Advanced ceramic materials synthesis
- biodegradable polymer synthesis and properties
- Orthopaedic implants and arthroplasty
- Dental Implant Techniques and Outcomes
- Minerals Flotation and Separation Techniques
- Electrophoretic Deposition in Materials Science
- Radioactive element chemistry and processing
- Recycling and utilization of industrial and municipal waste in materials production
- Education and Digital Technologies
- Graphene and Nanomaterials Applications
- Nanoparticle-Based Drug Delivery
- Ferroelectric and Piezoelectric Materials
- Glass properties and applications
- Microencapsulation and Drying Processes
- Advanced materials and composites
- Electrostatics and Colloid Interactions
- Polymer Surface Interaction Studies
- Thermodynamic and Structural Properties of Metals and Alloys
- Diabetes Treatment and Management
- Thermal and Kinetic Analysis
- Recycled Aggregate Concrete Performance
- Coagulation and Flocculation Studies
- Research on Leishmaniasis Studies
University of Aveiro
2011-2024
Universidade Federal de Alagoas
2018
University of Évora
2018
Virginia Commonwealth University Medical Center
1995
Instituto Português de Oncologia Francisco Gentil
1995
In spite of recent efforts to eradicate malaria in the world, this parasitic disease is still considered a major public health problem, with total 216 million cases and 445,000 deaths 2016. Artemisinin-based combination therapies remain effective most parts but resistance Southeast Asia have urged for novel approaches treat caused by Plasmodium falciparum. work, we present chloroquine analogs that exhibited high activity against sensitive chloroquine-resistant P. falciparum blood parasites...
Hydroxyapatite (Hap) is a calcium phosphate with chemical formula that closely resembles of the mineral constituents found in hard tissues, thereby explaining its natural biocompatibility and wide biomedical use. Nanostructured Hap materials appear to present good performance bone tissue applications because their ability mimic dimensions components. However, cell response individual nanoparticles and/or nanoparticle aggregates lost from these largely unknown shows great variability. This...
This work is focused on the potential role of citrate-derived species as tailoring agents for morphology hydroxyapatite particles during their synthesis. Under hydrothermal conditions (T = 180 °C), precursor solutions with different initial citrate:calcium molar ratios (R) allow nucleation and growth whose final shows a significant dependence citrate amount time. Increasing R from 3:1 to 7:1 causes evolve needlelike- rodlike-shaped nanoparticles toward larger microparticles hedgehoglike or...
Hydroxyapatite nanoparticles decorated with gold dots, synthesized by a citrate mediated chemical method, enhance the osteogenic differentiation of HMSC.
Hydroxyapatite (HAP, Ca10(PO4)6(OH)2) was studied from first principles approaches using the local density approximation (LDA) method in combination with various quantum-chemical (QM) and molecular mechanical (MM) methods HypemChem 7.5/8.0. The data then were used for studies of HAP structures, interactions clusters ionic species such as citrates. Computed show that can co-exist different phases at room temperature, both hexagonal monoclinic. Special interest is connected ordered monoclinic...
We reviewed 13 cases of small non-cleaved cell (Burkitt's) lymphoma diagnosed by fine-needle aspiration biopsy (FNAB) and four where that diagnosis was made from touch imprints surgical specimens. The most common site intraabdominal. Histologic confirmation present in 14/17 cases. General microscopic features on smears included high cellularity an individual pattern. Extracellular lymphoglandular bodies were abundant tingible body macrophages prominent. Nuclei intermediate size round with a...
Non-invasive routes for insulin delivery are emerging as alternatives to currently painful subcutaneous injections. For pulmonary delivery, formulations may be in powdered particle form, using carriers such polysaccharides stabilise the active principle. Roasted coffee beans and spent grounds (SCG) rich polysaccharides, namely galactomannans arabinogalactans. In this work, were obtained from roasted SCG preparation of insulin-loaded microparticles. The galactomannan arabinogalactan-rich...
Nanosized hydroxyapatite (HA) is a promising material in clinical applications targeting the bone tissue. NanoHA able to modulate cellular events, which accounts for its potential utility, but also raises safety concerns regarding maintenance of homeostasis. This work analyses effects HA nanoparticles (HAnp) on osteoclastic differentiation and activity, an issue that has been barely addressed. Rod-like HAnp, produced by hydrothermal precipitation method, were tested peripheral blood...
The influence of locust bean gum (LBG) galactomannans (GMs) molecular weight (Mw) to assemble microparticulate systems was evaluated, and carriers for deep lung delivery were developed. A commercial batch LBG with a mannose/galactose (M/G) ratio 2.4 (batch 1) used study the different microwave partial acid hydrolysis conditions on carbohydrate composition, glycosidic linkages, aqueous solutions viscosity. treatment did not affect presenting 4-Man (36-42 %), 4,6-Man (27-35 T-Gal (24-25 %) as...
Cost effective and safely to apply tissue engineered constructs of big volume bone transplants for the reconstruction critical sized defects (CSD) are still not available. Key problems with synthetic scaffold materials shrinkage fast degra
In our previous work we described the preparation and characterization of spray dried hydroxyapatite micro granules loaded with 5-fluorouracil (5-FU). These particles are used as a model drug delivery system (DDS). this study examined in vitro response two cell lines derived from different tissues to 5-FU (LG). Both lines, either L929 cells mouse fibroblast lineage or originating rat osteosarcoma (ROS 17/2.8) showed dose dependent decrease proliferation 5-FU-, dissolved culture medium onto...
Porous chitosan/brushite composite scaffolds were prepared by a freeze-drying technique, starting from brushite suspensions in chitosan solutions. The obtained showed regular macroporous and interconnected structure with particles uniformly distributed the matrix. variation of concentration affected microstructure final freeze-dried scaffold, particular, its porosity average pore size. yield strengths could also be improved increase content.
The results of computational modeling for Hydroxyapatite (HAP) nanostructures and surface interactions properties are presented in this work. HAP were studied from first principles approaches using Local Density Approximation (LDA) method combination with various quantum-chemical (QM), including Functional Theory (DFT) methods, molecular mechanical (MM, BIO CHARM) methods HypemChem 7.5/8.0 package. Obtained data then used studies clusters species (citrates, carbon nanotubes, living cells -...