A5001355402- interferon and immune responses
- Toxoplasma gondii Research Studies
- Cytomegalovirus and herpesvirus research
- Lipid metabolism and biosynthesis
- Phagocytosis and Immune Regulation
- Autophagy in Disease and Therapy
- Cellular transport and secretion
- Immune cells in cancer
- HIV Research and Treatment
- Endoplasmic Reticulum Stress and Disease
The University of Texas Southwestern Medical Center
2021-2025
Center for Life Sciences
2018
Tsinghua University
2018
Lipid incorporation from endoplasmic reticulum (ER) to lipid droplet (LD) is important in controlling LD growth and intracellular homeostasis. However, the molecular link mediating ER cross talk remains elusive. Here, we identified Rab18 as an Rab guanosine triphosphatase maturation. deficiency resulted a drastically reduced number of mature LDs decreased storage, was accompanied by increased stress. Rab3GAP1/2, GEF Rab18, promoted activating targeting LDs. LD-associated bound specifically...
The cyclic guanosine monophosphate (GMP)-adenosine (AMP) synthase (cGAS) detects microbial and self-DNA in the cytosol to activate immune inflammatory programs. cGAS also associates with chromatin, especially after nuclear envelope breakdown when cells enter mitosis. How is regulated during cell cycle transition not clear. Here, we found direct biochemical evidence that activity was selectively suppressed mitosis human lines uncovered two parallel mechanisms underlying this suppression....
The cGAS–STING pathway mediates innate immune responses to cytosolic DNA. In addition its well-established role in inducing inflammatory cytokines, activation of the also induces noncanonical autophagy, a process involving conjugation ATG8 family ubiquitin-like proteins membranes endolysosomal system. mechanisms and functions STING-induced autophagy remain poorly understood. this study, we demonstrated that STING induced formation pH-elevated Golgi-derived vesicles led ATG16L1...
Abstract The cyclic GMP-AMP synthase (cGAS) detects microbial and self-DNA in the cytosol to activate immune inflammatory programs. cGAS also associates with chromatin especially after nuclear envelop breakdown when cells enter mitosis. How is regulated during cell cycle transition not clear. In this presentation, we will provide direct biochemical data showing that activity selectively suppressed mitosis, report two parallel mechanisms underlying suppression. First, discovered...