A5103005665- Asthma and respiratory diseases
- Vasculitis and related conditions
- Eosinophilic Disorders and Syndromes
- Vitamin D Research Studies
- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
- Systemic Sclerosis and Related Diseases
- Sarcoidosis and Beryllium Toxicity Research
- Air Quality and Health Impacts
- Peroxisome Proliferator-Activated Receptors
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inhalation and Respiratory Drug Delivery
- Colorectal Cancer Treatments and Studies
- Cancer, Lipids, and Metabolism
- Climate Change and Health Impacts
- Adrenal Hormones and Disorders
- Neurological and metabolic disorders
- Allergic Rhinitis and Sensitization
- Neuroblastoma Research and Treatments
- Noise Effects and Management
- Urticaria and Related Conditions
- Energy and Environment Impacts
- Neuroendocrine Tumor Research Advances
- T-cell and B-cell Immunology
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
Guy's and St Thomas' NHS Foundation Trust
2021-2024
King's College London
2010-2024
St Thomas' Hospital
2024
Asthma UK
2010-2017
Queen Mary University of London
2013-2017
Royal Brompton Hospital
2014
Royal Brompton & Harefield NHS Foundation Trust
2014
Guy's Hospital
2010
St Bartholomew's Hospital
2003
BackgroundA small population of patients with severe asthma does not respond to glucocorticoids (steroid resistant [SR]). They have high morbidity, highlighting an urgent need for strategies enhance glucocorticoid responsiveness.ObjectiveWe investigated the immunologic differences between steroid-sensitive (SS) and SR asthmatic effect on immunophenotype oral calcitriol treatment because it has been previously shown beneficially modulate clinical response in asthma.MethodsCD8-depleted PBMCs...
Summary Objective It has been reported that both normal pituitary and tumours express PPAR‐γ, a nuclear hormone receptor, the expression being more abundant in tumours, this is basis for antiproliferative effects of thiazolidinedione, rosiglitazone, animal models. However, mechanisms responsivity to rosiglitazone have remained unclear. Design measurements To investigate further, ‘real‐time’ PCR was used assess PPAR‐γ mRNA expression, Western blotting immunohistochemistry study its protein 46...
Summary Background Subsets of patients with severe asthma remain symptomatic despite prolonged, high‐dose glucocorticoid therapy. We hypothesized that the clinical sensitivity these asthmatics is reflected in differences peripheral blood dendritic cell subsets. Objective To compare leucocyte populations using flow cytometry at baseline and after 2 weeks systemic (steroid) treatment to identify immunological between steroid‐sensitive ( SS ) steroid‐resistant SR asthmatics. Methods Adult n =...
<h3>Introduction and Objectives</h3> The BPAP study has previously described real-world outcomes of patients with severe eosinophilic asthma (SEA) following 1 year treatment benralizumab. It is recognised that obesity can be an independent driver respiratory symptoms in associated additional non-T2 inflammatory pathways. Whether co-morbid SEA a differential response to benralizumab poorly understood. <h3>Methods</h3> retrospective, observational from eight UK centres. Clinical were at...
A 78-year-old man presented with severe exertional dyspnoea. He suffered from mild chronic obstructive pulmonary disease, congestive cardiac failure and seropositive myasthaenia gravis. Clinical examination of his chest heart were unremarkable but he had speech dyspnoea was unable to count 20 in a single breath. Consecutive sniff nasal inspiratory measurements (SNIP) fell 55 33 cm H 2 O forced vital capacity (FVC) 3.4 2.4 L. diagnosis myasthenic crisis carried out treatment non-invasive...
An 18-year-old patient with metabolic myopathy due to long-chain fatty acid coenzyme A dehydrogenase-deficiency1 ,2 presented worsening positional dyspnoea. He had required invasive ventilation via tracheostomy 6 months earlier. Examination revealed respiratory distress, a prolonged inspiratory phase and …
Background: EGPA is a rare small-vessel vasculitis. Cardiovascular (CV) involvement an important predictor of adverse outcomes but challenging to detect. CMR as excellent tool detect cardiac not widely available. It unknown who would benefit most from comprehensive CV assessment with CMR. We aimed determine the prevalence multiparametric and identify potential clinical/biochemical predictors involvement. Methods: This single-center study was performed in patients underwent part routine...