Nigella sativa (NS) has been suggested to have neuroprotective and anti-seizures properties. The aim of current study was investigate the effects NS hydro-alcoholic extract on neural damage after pentylenetetrazole (PTZ) - induced repeated seizures. rats were divided into five groups: (1) control (saline), (2) PTZ (50 mg/kg, i.p.), (3-5) PTZ-NS 100, 200 400 (100, mg/kg respectively, 30 min prior each injection 5 consecutive days). passive avoidance (PA) test done brains then removed for...

Clinical applications of mesenchymal stem cells (MSCs) rely on their capacity to home and engraft in the appropriate target injury tissues for long term. However, homing efficiency has been observed be very poor because lack or modifications factors SDF-1α CXCR4 receptors. Hence, this study was designed investigate retention pretreated human adipose tissue-derived MSCs (hASCs) from three different delivery routes response SDF-1α, released chitosan-based injectable hydrogels. After...

Obesity, a rising global health issue, is linked to numerous disorders, including cognitive impairment. This study investigates the effects of coenzyme Q10 (Co-Q10) on performance, antioxidant defense, cholinergic activity, and hippocampal neuron damage in rats rendered obese by monosodium glutamate (MSG) exposure. Forty-eight neonatal male Wistar were randomly assigned one four groups: Control, MSG, MSG + Q10-10, Q10-20. Monosodium (4 g/kg BW) was administered subcutaneously into cervical...

Autophagy is also essential for both male and female infertility since it controls the development of germ cells reproductive organs. This study aimed to investigate effects taurine curcumin on expression genes related autophagy in acrylamide-treated mice. In 2022, this experimental was conducted at Shiraz University Medical Sciences, Stem Cells Technology Research Centre. Forty-eight mice were randomly assigned eight groups (control, 200 mg/Kg, 150 acrylamide 50 acrylamide+curcumin 100 200,...

Abstract Background Novel threads of discovery provide the basis for optimism development a stem‐cell‐based strategy treatment retinal blindness. Accordingly, achievement to suitable cell source with potential‐to‐long‐term survival and appropriate differentiation can be an effective step in this direction. Methods After derivation human adipose‐derived mesenchymal stem cells ( HAD ‐ MSC s), they were stably transfected vector containing Turbo‐green fluorescent protein GFP ) JR ed able trace...

Abstract Background: The cerebellum has been considered a key structure for the processes involved in sensorimotor integration ultimately leading to motor planning and execution of coordinated movement. Thus, deficits behavioral changes can be associated with cerebellar degeneration. Methods: Here, chemical neurotoxin pyridine-2,3-dicarboxylic acid (quinolinic acid, QA) used create partially degeneration adult Wistar rats suitable use stem cell transplantation studies. Stereotaxicaly...

Huntington's disease (HD) is an inherited neurodegenerative disorder that usually occurs in the third or fourth decades of life. Stem cell therapy one approaches for HD treatment. Since mesenchymal stem cells (MSCs) have ability to migrate into lesioned site, we transplanted rat bone marrow-derived MSCs intravenously, following unilateral intrastriatal lesion made by quinolinic acid (QA) Wistar rats. QA administration caused widespread neuropathological deficits similar those found HD,...

The present study investigated the effects of gallic acid (GA) administration on trimethyltin chloride (TMT) induced anxiety, depression, and hippocampal neurodegen- eration in rats.In this experimental study, rats received intraperitoneal (i.p.) injections TMT (8 mg/kg). animals either GA (50, 100 150 mg/kg) or saline as vehicle for 14 consecutive days. We measured depression anxiety levels by conducting behavioral tail suspension (TST), elevatedplusmaze (EPM), novelty suppressed feeding...

Cerebral ischemia/reperfusion (I/R) causes brain inflammation that ultimately long time function disturbances. We aimed to evaluate the effect of ellagic acid (EA) on anxiety, depression, locomotion behaviors, blood-brain barrier (BBB) permeability, edema, and in male rats with cerebral I/R.Sixty Wistar (250-300 g) divided into 6 groups randomly 10 each: 1) Sham+Veh; submitted surgery without any I/R received vehicle (10% DMSO normal saline 5 ml/kg, gavages). 2) I/R+Veh; 3-5) I/R+EA; 50, 75...

Background: Acrylamide (ACR) has cytotoxic effects on various tissues of the body, including reproductive system. The purpose this study was to evaluate protective N-acetylcysteine (NAC) changes in serum levels pituitary–gonadal axis hormones and testicular tissue ACR-treated adult rats. Materials Methods: Forty-two male Wistar rats were randomly divided into 7 equal groups control group, sham group received only distilled water intraperitoneally, ACR 50 mg/kg orally, NAC 40...

Human mesenchymal stem cells (hMSCs) have been presented as alternative sources of to be transplanted into the brain in neurodegenerative disorders. In this regard, efficacy hMSCs transplants reducing motor and non-motor deficits a quinolinic acid (QA) rat model Huntington's disease (HD) was tested present study. After unilateral lesions striatum by QA, isolated purified from liposuction healthy male donors were damaged rats. The stably transfected with vector containing TurboGFP JRed make...

Polycystic ovary syndrome (PCOS) is the most common cause of infertility without ovulation. Aromatase inhibitors were first proposed as new ovulation-inducing drugs in anovulatory women with an inadequate response to clomiphene. Letrozole aromatase inhibitor used ovulation inducer infertile due PCOS. However, there no definitive treatment for PCOS and treatments are mostly symptomatic. In this study, we intend introduce alternative letrozole using library FDA-approved evaluate interaction...

Introduction: Polycystic ovary syndrome (PCOS) is the communal endocrine illness in women and most common cause of infertility due to lack ovulation. The exact PCOS still unknown. Affected may have difficulty getting pregnant ovulation problems. Various methods not been effective treatment positive role photobiomodulation therapy (PBMT) extracellular vesicles (ECV) obtained from cord blood plasma various diseases. aim this study was ECV PBMT maturation improvement with PCOS. Methods: In...

Background: In the present study, effects of endurance training and chronic administration Gallic acid (GA) on hippocampal level brain-derived neurotrophic factor (BDNF) tumor necrosis alpha (TNF-α) in trimethyltin (TMT)-induced degeneration as a model Alzheimer’s disease were investigated. Methods: 70 male Sprague-Dawley rats selected randomly assigned to 7 groups: 1.control, 2.TMT, 3.TMT+GA50, 4.TMT+GA100, 5.TMT+Ex, 6.TMT+Ex+GA50, 7.TMT+Ex+GA100. For induction Alzheimer's disease, groups...

Alzheimer’s disease (AD) can be described by characteristics like dementia, mental and cognitive dysfunctions, memory impairment. Nowadays, with progresses of science, attempts to treat many diseases have increased. Laboratory animals help discover new ways treating disease. AD induced chemical drugs in animal models useful better understanding the mechanisms treatment AD. In recent decades, researchers reported transgenic rat but this modeling has a great problem does not contain all...

Effect of Gallic Acid and Endurance Exercise Training on BDNF in a Model Hippocampal Degeneration