A5031480779- Neurogenesis and neuroplasticity mechanisms
- Neurological Disease Mechanisms and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Biochemical effects in animals
- Thyroid Disorders and Treatments
- Neuroscience and Neural Engineering
- Neurological Disorders and Treatments
- Nigella sativa pharmacological applications
- Anesthesia and Neurotoxicity Research
- Stress Responses and Cortisol
- Alcoholism and Thiamine Deficiency
- Tryptophan and brain disorders
- Pharmacological Effects of Natural Compounds
- Vitamin C and Antioxidants Research
- Histone Deacetylase Inhibitors Research
- Saffron Plant Research Studies
- Curcumin's Biomedical Applications
- Medicinal Plants and Neuroprotection
- Medicinal Plants and Bioactive Compounds
- Neurogenetic and Muscular Disorders Research
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- Natural product bioactivities and synthesis
Mashhad University of Medical Sciences
2014-2025
Shiraz University of Medical Sciences
2017-2020
Minocycline, a tetracycline derivative, has been found to exert neuroprotective properties. The current project aimed assess the antioxidant status and cholinergic function in amnesia induced by scopolamine.We evaluated passive avoidance performance, acetylcholine esterase (AChE) enzyme activity, oxidative stress indicators following groups: Normal control, scopolamine, treatment groups (the animals were given minocycline (10-30 mg/kg)).Scopolamine (intraperitoneal) injection was associated...
Background: Neuroimmune factors have been proposed as contributors to the pathogenesis of depression. Beside other therapeutic effects including neuroprotective, antioxidant, anticonvulsant and analgesic effects, Nigella sativa its main ingredient, thymoquinone (TQ), shown anti-inflammatory effects. In present study, hydro-alcoholic extract was investigated on lipopolysaccharide- induced depression like behavior in rats. Materials Methods: 50 male Wistar rats were divided into 5 groups:...
Objectives: It has been shown that hypothyroidism-induced oxidative damage in brain tissue is involved its adverse effects on learning and memory. Nigella sativa (N. sativa) suggested to have antioxidant neuroprotective effects. The objective of this study was investigate the hydroalcoholic extract N. hypothyroidism-associated memory impairment during neonatal juvenile growth rats.Methods: Thirty pregnant rats were kept separate cages. After delivery, mothers their offspring randomly divided...
In the present study, effect of aqueous extracts saffron on morphine-induced memory impairment was investigated. On training trial, mice received an electric shock when animals were entered into dark compartment. Twenty-four and forty-eight hours later, time latency for entering compartment recorded defined as retention trial. The divided (1) control, (2) morphine which before in passive avoidance test, (3–5) three groups treated by 50, 150 450 mg/kg extract (6 7) two other morphine-treated...
The positive roles of antioxidants on brain development and learning memory have been suggested. Nigella sativa (NS) has suggested to antioxidant neuroprotective effects. This study was done investigate the effects feeding by hydro-alcoholic extract NS during neonatal juvenile growth rats. pregnant rats were kept in separate cages. After delivery, they randomly divided into four Groups including: (1) control; (2) 100 mg/kg (NS 100); (3) 200 200); (4) 400 400). Rats control group (Group 1)...
Objective. The effects of hydroalcoholic extract Teucrium polium and metformin on diabetes-induced memory impairment brain tissues oxidative damage were investigated. Methods. rats divided into: (1) Control, (2) Diabetic, (3) Diabetic-Extract 100 (Dia-Ext 100), (4) 200 200), (5) 400 400), (6) Diabetic-Metformin (Dia-Met). Groups 3–6 treated by 100, 200, mg/kg the or metformin, respectively, for 6 weeks (orally). Results . In passive avoidance test, latency to enter dark compartment in...
Objective: The neuroprotective effects of both garlic and ascorbic acid (AA) have been documented. In this study the on memory deficits brain tissue oxidative damages induced by lead exposure was investigated. Methods: juvenile rats were divided treated: (1) Control, (2) Lead (lead acetate in drinking water, 8 weeks), (3) – Ascorbic Acid (Lead-AA), (4) Garlic (100 mg/kg, daily, gavage) (Lead-Gar). Results: Morris water maze (MWM), escape latency traveled path group significantly higher...
Neuropathic pain originating from a dysfunction in the nervous system is often intractable and chronic. Recently, several studies using nanoparticles suggested new way to control neuropathic pain. This study intended explore potential neuroprotective effect of Cerium Oxide Nanoparticles (CNPs) synthesized by pullulan rats.On right common sciatic nerve male Wistar rats, chronic constriction injury (CCI) procedure was used establish model. CNPs were injected into caudal vein rat. Behavioral...
ObjectivesHypnotic, analgesic, anticonvulsant, and antioxidant effects of Rosa damascena have been reported. This study, investigated the effect R. hydroalcoholic extract on memory performance in a scopolamine-induced impairment model.MethodsThe rats were divided into control group received just saline; scopolamine was treated by saline for 2 weeks, but injected 30 minutes before each trial Morris water maze test; treatment groups (scopolamine + 50; Sco Ext 50) 250; 250) daily 50 250 mg/kg...
Anti-inflammatory and anti-oxidant agents can alleviate ischemic cerebral injury. The immunomodulary drug Setarud, which is composed of herbal extracts including Rosa canina, Urtica dioica Tanacetum vulgare, supplemented with selenium exhibits anti-inflammatory properties. Therefore, we hypothesized that Setarud will have a neuroprotective effect against To validate this hypothesis, rats were intraperitoneally administered 0.66 mL/kg for 30 minutes after middle artery occlusion....