A5044754567- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Medical Imaging Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Frailty in Older Adults
- Traumatic Brain Injury Research
- Neural and Behavioral Psychology Studies
- Advanced MRI Techniques and Applications
- Essential Oils and Antimicrobial Activity
- Neural dynamics and brain function
- Neonatal Respiratory Health Research
- Cerebrospinal fluid and hydrocephalus
- Memory and Neural Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lanthanide and Transition Metal Complexes
- Mesenchymal stem cell research
- Analytical Methods in Pharmaceuticals
- Radiomics and Machine Learning in Medical Imaging
- Dye analysis and toxicity
- Flavonoids in Medical Research
- Neuroscience and Neuropharmacology Research
- Analytical Chemistry and Chromatography
- Saffron Plant Research Studies
- Health, Environment, Cognitive Aging
Florey Institute of Neuroscience and Mental Health
2022-2025
The University of Melbourne
2022-2025
Austin Health
2022-2025
Monash University
2016-2024
Australian Regenerative Medicine Institute
2016-2020
Australian Research Council
2020
Mashhad University of Medical Sciences
2011-2016
Background: 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) regulates intracellular cortisol and its inhibition by the small molecule inhibitor, Xanamem™, may provide a disease-modifying strategy for Alzheimer’s disease (AD). Animal models suggest range of 30–60% enzyme suffice to neuroprotection. Objective: To determine regional brain occupancy 11β-HSD1 Xanamem™ in cognitively normal participants (CN) mild cognitive impairment (MCI)/mild AD patients investigate potential dosing ranges...
The introduction of therapeutics for Alzheimer's disease has led to increased interest in precisely quantifying amyloid-β (Aβ) burden diagnosis, treatment monitoring, and further clinical research. Recent positron emission tomography (PET) hardware innovations including digital detectors have superior resolution sensitivity, improving quantitative accuracy. However, the effect PET scanner on Centiloid remains relatively unexplored is assumed be minimized by harmonizing resolutions. To...
Plasma p-tau217 and tau positron emission tomography (PET) are strong prognostic biomarkers in Alzheimer's disease (AD), but their relative performance predicting future cognitive decline among cognitively unimpaired (CU) individuals is unclear. In a head-to-head comparison study including nine cohorts 1,474 individuals, we show that plasma medial temporal lobe tau-PET signal display similar associations with on global composite test (R2PET = 0.34 versus R2plasma 0.33, Pdifference 0.653)...
Objective: The neuroprotective effects of both garlic and ascorbic acid (AA) have been documented. In this study the on memory deficits brain tissue oxidative damages induced by lead exposure was investigated. Methods: juvenile rats were divided treated: (1) Control, (2) Lead (lead acetate in drinking water, 8 weeks), (3) – Ascorbic Acid (Lead-AA), (4) Garlic (100 mg/kg, daily, gavage) (Lead-Gar). Results: Morris water maze (MWM), escape latency traveled path group significantly higher...
Traumatic brain injury (TBI) is common among military veterans and has been associated with an increased risk of dementia. It unclear if this due to for Alzheimer's disease (AD) or other mechanisms. This case control study sought evidence AD, as defined by the 2018 National Institute on Aging - Association (NIA-AA) research framework, measuring tau, β-amyloid, glucose metabolism using positron emission tomography (PET) in service-related TBI. Seventy male Vietnam war veterans—40 TBI (age...
Commission of errors and conflict between choices might induce behavioral modulations through adjustments in the executive control behavior altered patterns these are detected neuropsychiatric disorders. We examined effects transcranial Direct Current Stimulation (tDCS) applied over dorsolateral prefrontal cortex (DLPFC) on error- conflict-induced modulations. Two separate cohorts participants performed two clinically relevant tests control, respectively. In Wisconsin Card Sorting Test...
The effects of adipose derived stromal cells (ASCs) were evaluated on tracheal responsiveness and biochemical parameters in guinea pigs model chronic obstructive pulmonary disease (COPD). Thirty six divided into 6 groups including: Control, COPD, COPD+intratracheal delivery PBS (COPD+ITPBS), COPD+intravenous (COPD+IVPBS), ASCs (COPD+ITASC) injection (COPD+IVASC). COPD was induced by exposing animals to cigarette smoke for 3 months. Cell therapy then performed after 14 days, responsiveness,...
Plasma p-tau217 and Tau-PET are strong prognostic biomarkers in Alzheimer's disease (AD), but their relative performance predicting future cognitive decline among cognitively unimpaired (CU) individuals is unclear. In this head-to-head comparison study including 9 cohorts 1534 individuals, we found that plasma medial temporal lobe signal showed similar associations with on a global composite test (R
The marmoset monkey (Callithrix jacchus) has gained attention in neurophysiology research as a new primate model for visual processing and behavior. In particular, marmosets have lissencephalic cortex, making multielectrode, optogenetic, calcium-imaging techniques more accessible than other models. However, the degree of homology brain circuits behavior with those identified macaques humans is still being ascertained. For example, whereas location frontal eye fields (FEF) within dorsolateral...
ABSTRACT Tau deposition plays a critical role over cognition and neurodegeneration in Alzheimer’s disease (AD). Recent generation tracers have high target to background ratios giving wide dynamic range that may improve sensitivity for detection of low levels tau (Pascoal, Shin et al. 2018). Building on previous evidence, this study aims characterize the effects as assessed by 18 F-MK6240, large cohort patients across AD spectrum. A total 464 participants, enrolled AIBL-ADNeT study, underwent...
Abstract Background New generation PET scanners achieve superior resolution and sensitivity, but the implications on beta amyloid (Aβ) quantitation are not well understood. The Centiloid (CL) scale (Klunk et al., 2015) was introduced to promote consistent Aβ burden quantification across different positron emission tomography (PET) tracers pipelines, intended control for hardware or reconstruction changes. Instead, post‐reconstruction smoothing harmonisation (Joshi, Koeppe, Fessler, 2009) is...
Recent studies suggest that females and males show different levels of susceptibility to neuropsychological disorders which might be related sex differences in executive control behaviour. Music, as a cognitively salient factor, influence cognitive functions; however, it is unclear how music interact influencing behaviour dynamic environment. We tested female male participants computerized analogue the Wisconsin Card Sorting Test (WCST) while listening or silence. found decreased percentage...
<b>Objective:</b> To investigate one possible mechanism for the observed relaxant effect of <i>A. millefolium</i> (<i>Achillea millefolium</i>), in present study inhibitory extract this plant on muscarinic receptors was examined.<br><b>Materials and Methods:</b> The effects three concentrations aqueous-ethanolic extract, 10 nM atropine, saline were tested conditions: In non incubated tracheal smooth muscle (group 1), chain with propranolol chlorpheniramine 2), 3).<br><b>Results:</b> EC...
Abstract Background: Plasma p217+tau has shown high concordance with cerebrospinal fluid (CSF) and positron emission tomography (PET) measures of amyloid-β (Aβ) tau in Alzheimer’s Disease (AD). However, its association longitudinal cognition comparative performance to PET Aβ predicting cognitive decline are unknown. Objectives: To evaluate whether can predict the rate observed over two-year average follow-up compare this prediction based on ( 18 F-NAV4694) F-MK6240) PET. We also explored...
Abstract Background A standardized scale for the quantification of tau PET imaging would allow comparison and combination data across tracers sites resulting in large meta‐analysis application universal cut‐offs. The proposed approach called CenTauR (CTR) was evaluated on 18 F‐MK6240 using both global regional anchoring. Method 375 & T1w scan pairs (HC Aβ‐ = 179/MCI Aβ+ 98/AD 98) from AIBL&ADNeT were spatially normalised SPM8 SUVR cerebellar cortex. scans then quantified 4 composite...
Different pharmacological effects of Achillea millefolium including its relaxant effect on smooth muscle have been shown previously. In the present study stimulatory plant extract β-adrenoceptor tracheal was examined in order to investigate one possible mechanism for observed effect. Effect three concentrations hydroethanol extract, 10 nM propranolol, and saline tested two experimental groups including; nonincubated muscles (group 1) incubated with chlorpheniramine 2). Concentration response...
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Abstract Background Tau PET is instrumental in tracking the longitudinal progression of Alzheimer's disease (AD). 18 F‐MK6240 a high affinity tracer targeting 3R/4R paired helical filaments tau AD. We aimed to evaluate early phase natural accumulation using F‐MK6240. Method 231 participants: 100 cognitively unimpaired (CU) Aβ− (Centiloid<25CL), 58 CU Aβ+, 73 impaired Aβ+ (41 with mild cognitive impairment (MCI) and 32 dementia) from AIBL cohort were followed‐up over one four years (median...