A5002603242- Saffron Plant Research Studies
- Stress Responses and Cortisol
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- Regulation of Appetite and Obesity
- Medicinal Plants and Bioactive Compounds
- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
- Multiple Sclerosis Research Studies
- Eosinophilic Esophagitis
- Prenatal Substance Exposure Effects
- Pain Mechanisms and Treatments
- Neurological Disease Mechanisms and Treatments
- Glaucoma and retinal disorders
- Flavonoids in Medical Research
- Genetic Neurodegenerative Diseases
- Cytokine Signaling Pathways and Interactions
- Healthcare and Venom Research
- Hedgehog Signaling Pathway Studies
- Health and Well-being Studies
- Research on Leishmaniasis Studies
- Ophthalmology and Visual Health Research
- Hematological disorders and diagnostics
- Central Venous Catheters and Hemodialysis
- Neurotransmitter Receptor Influence on Behavior
Kermanshah University of Medical Sciences
2024
Shiraz University of Medical Sciences
2023
Tarbiat Modares University
2022-2023
Isfahan University of Medical Sciences
2017-2022
Mashhad University of Medical Sciences
2012
In the present study, effect of aqueous extracts saffron on morphine-induced memory impairment was investigated. On training trial, mice received an electric shock when animals were entered into dark compartment. Twenty-four and forty-eight hours later, time latency for entering compartment recorded defined as retention trial. The divided (1) control, (2) morphine which before in passive avoidance test, (3–5) three groups treated by 50, 150 450 mg/kg extract (6 7) two other morphine-treated...
There is an increase in inflammatory and a reduction anti-inflammatory cytokines multiple sclerosis (MS). Considering the role of thyroid hormones development regulation both neural immune systems, aim this study was to evaluate effects levothyroxine on serum concentrations interleukin-10 (IL-10) interferon gamma (IFN-γ) animal models MS.To induce demyelination male Wistar rats, lysolecithin injected into optic chiasm. Then intraperitoneally (20, 50, 100 μg/kg) for 21 days. Serum levels were...
Abstract Epidemiological studies show the prevalence of opioid use, misuse and abuse in adolescents, which imposes social economic accountability worldwide. Chronic exposure, especially may have lasting effects on emotional behaviors that persist into adulthood. The current experiments were therefore designed to study sustained exposure during adolescence anxiety‐like behaviors. Adolescent male Wistar rats underwent increasing doses morphine for 10 days (PNDs 31–40). After open field test...
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system which has no any known definitive treatment. Studies have shown that thyroid hormones (THs) in addition to their roles development and production myelin important adult's brain function. Since only way treat MS restoration myelin, aim this study was evaluate effects levothyroxine on visual evoked potential (VEP) impairment following local injections lysolecithin into rat optic chiasm.To induce demyelination,...
The clinical use and abuse of opioids during human pregnancy have been widely reported. Several studies demonstrated that cross the placenta in rats late gestation, prenatal morphine exposure has shown to negative outcomes cognitive function. medial prefrontal cortex (mPFC) is believed play a crucial role processes, motivation, emotion, integrating neural information from several brain areas sending converted other structures. Dysfunctions this area observed numerous psychiatric neurological...
The lack of social communication is associated with the primary risk proper brain functions. It reported that crocin helps relieve this problem. present study examined protective effect two doses on Long-term potentiation (LTP) hippocampal cornu ammonis 1 (CA1) area as a cellular mechanism in rats exposed to chronic isolated stress.Rats were assigned control, sham, isolation stress, and stress groups (receiving 30 60 mg/kg crocin). Chronic (CIS) was induced 6 h/d, administrated for 21 days....
Adolescence represents a distinctive vulnerable period when exposure to stressful situations including opioid can entail lasting effects on brain and change neural mechanisms involved in memory formation for drug-associated cues, possibly increasing vulnerability of adolescents addiction. Herein, the acute adolescent morphine (AAME, two injections 2.5 mg/kg SC PND 31) were therefore investigated 6 weeks later (adulthood) avoidance hippocampal long-term potentiation (LTP) at Schaffer...
The Impact of Crocin and Chronic Isolation Stress on Passive Avoidance Memory Brain Electrical Activity in Male Rats