A5003502101- Mesenchymal stem cell research
- Liver physiology and pathology
- Pharmacogenetics and Drug Metabolism
- Drug-Induced Hepatotoxicity and Protection
- Extracellular vesicles in disease
- Tissue Engineering and Regenerative Medicine
- Long-Term Effects of COVID-19
- Diabetic Foot Ulcer Assessment and Management
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Head and Neck Cancer Studies
- Pancreatic function and diabetes
- Oral health in cancer treatment
- Poisoning and overdose treatments
- Metabolism, Diabetes, and Cancer
- Advanced Drug Delivery Systems
- Drug Transport and Resistance Mechanisms
- Pluripotent Stem Cells Research
- Pharmacological Effects and Toxicity Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- 3D Printing in Biomedical Research
- Organ Transplantation Techniques and Outcomes
- Metastasis and carcinoma case studies
- Liver Disease Diagnosis and Treatment
University of Lisbon
2021-2024
Doxorubicin (Dox) is one of the most widely used treatments for breast cancer, although limited by well-documented cardiotoxicity and other off-target effects. Mesenchymal stem cell (MSC) secretome has shown immunomodulatory regenerative properties, further potentiated under 3D conditions. This work aimed to uncover effect MSC-derived from (CM3D) or 2D (CM2D) cultures, in human malignant cells (MDA-MB-231), non-tumor epithelial (MCF10A) differentiated AC16 cardiomyocytes, co-treated with...
Introduction The development of reliable hepatic in vitro models may provide insights into disease mechanisms, linking hepatocyte dysmetabolism and related pathologies. However, several the existing depend on using high concentrations differentiation-promoting compounds, namely glucose, insulin, dexamethasone, which is among reasons that have hampered their use for modeling metabolism-related diseases. This work focused modulating glucose homeostasis glucocorticoid concentration to improve...
<title>Abstract</title> Idiosyncratic drug-induced liver injury (DILI) is a complex and unpredictable event caused by different drugs, herbal, dietary supplements. The early identification of human hepatotoxicity at the preclinical stages remains major challenge, in which selection validated <italic>in vitro</italic> systems test drugs has significant impact. This systematic review aims to analyse compounds used assays establish unified list DILI positive negative control for validation...