A5010160449- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Herpesvirus Infections and Treatments
University of Szeged
2022-2024
Epstein-Barr virus (EBV) is an important human pathogenic gammaherpesvirus with carcinogenic potential. The EBV transcriptome has previously been analyzed using both Illumina-based short read-sequencing and Pacific Biosciences RS II-based long-read sequencing technologies. Since the various methods have distinct strengths limitations, use of multiplatform approaches proven to be valuable. aim this study provide a more complete picture on transcriptomic architecture EBV.In work, we apply...
Long-read sequencing (LRS) techniques enable the identification of full-length RNA molecules in a single run eliminating need for additional assembly steps. LRS research has exposed unanticipated transcriptomic complexity various organisms, including viruses. Herpesviruses are known to produce range transcripts, either close or overlapping replication origins (Oris) and neighboring genes related transcription replication, which possess confirmed potential regulatory roles. In our research,...
ABSTRACT In the last couple of years, rapid advances and decreasing costs sequencing technologies have revolutionized transcriptomic research. Long-read (LRS) techniques are able to detect full-length RNA molecules in a single run without need for additional assembly steps. LRS studies revealed an unexpected complexity variety organisms, including viruses. A number transcripts with proven or putative regulatory role, mapping close overlapping replication origins (Oris) nearby transcription...