A5069653955- T-cell and B-cell Immunology
- Cell Adhesion Molecules Research
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- Neonatal Respiratory Health Research
- interferon and immune responses
- Monoclonal and Polyclonal Antibodies Research
- Retinopathy of Prematurity Studies
- Liver Disease Diagnosis and Treatment
- Phagocytosis and Immune Regulation
- Cytokine Signaling Pathways and Interactions
- Digestive system and related health
- Lipid metabolism and disorders
- Immunotherapy and Immune Responses
- Atherosclerosis and Cardiovascular Diseases
- Endoplasmic Reticulum Stress and Disease
- Obesity and Health Practices
- Inflammasome and immune disorders
- Lung Cancer Treatments and Mutations
- Mast cells and histamine
- Reproductive System and Pregnancy
- Inflammatory Bowel Disease
- Preterm Birth and Chorioamnionitis
- Galectins and Cancer Biology
- Immune cells in cancer
Monash University
2015-2024
Hudson Institute of Medical Research
2023-2024
Monash Alfred Psychiatry Research centre
2024
The Alfred Hospital
2014
The epidemiological patterns of incident chronic obstructive pulmonary disease (COPD) and lung adenocarcinoma are changing, with an increasing fraction occurring in patients who never-smokers or were not exposed to traditional risk factors. However, causative mechanism(s) obscure. Overactivity Src family kinases (SFKs) myeloid cell-dependent inflammatory epithelial endothelial damage independent candidate mechanisms, but their pathogenic convergence has been demonstrated. Here we present a...
Cell death frequently occurs in the pathogenesis of obesity and metabolic dysfunction-associated fatty liver disease (MAFLD). However, exact contribution core cell machinery to manifestations remains ill-defined. Here, we show via direct comparison mice genetically deficient essential necroptotic regulators, receptor-interacting protein kinase-3 (RIPK3) mixed lineage kinase domain-like (MLKL), as well lacking apoptotic caspase-8 myeloid cells combined with RIPK3 loss, that RIPK3/caspase-8...
Systemic lupus erythematosus (SLE) is a complex, heterogeneous autoimmune disease. A common manifestation, nephritis, arises from immune complex deposition in the kidney microvasculature promoting leukocyte activation and infiltration, which triggers glomerular damage renal dysfunction. CD11b integrin mainly expressed on myeloid cells, aside its well-ascribed roles trafficking phagocytosis, it can also suppress cytokine production autoreactivity. Genome-wide association studies have...
The Lyn tyrosine kinase plays a key regulatory role in the immune system that was first highlighted by phenotype of Lyn-/- mice. These animals develop an autoimmune disease similar to disorder systemic lupus erythematosus. Deregulation pathway is also observed patient samples, validating mice as model lupus, well providing archetype for testing suitable therapeutic agents. Here, we present overview cells and autoimmunity, emphasizing pathogenic mechanisms contributing deregulation...
Systemic lupus erythematosus (lupus) is an autoimmune disease characterized by autoantibodies that form immune complexes with self-antigens, which deposit in various tissues, leading to inflammation and disease. The etiology of complex still not completely elucidated. Dysregulated important feature, the mainstay treatment utilizes nonspecific anti-inflammatory drugs. Granulocyte colony-stimulating factor (G-CSF) a growth, survival, activation for neutrophils mobilizer hematopoietic stem...
Bronchopulmonary dysplasia (BPD), also called chronic lung disease of immaturity, afflicts approximately one third all extremely premature infants, causing lifelong damage. There is no effective treatment other than supportive care. Retinopathy prematurity (ROP), which impairs vision irreversibly, common in BPD, suggesting a related pathogenesis. However, specific mechanisms BPD and ROP are not known. Herein, neonatal mouse hyperoxic model coincident retinopathy was used to screen for...
The leukocyte-restricted tetraspanin CD53 has been shown to promote lymphocyte homing lymph nodes (LNs) and myeloid cell recruitment acutely inflamed peripheral organs, accelerate the onset of immune-mediated disease. However, its contribution in setting chronic systemic autoimmunity not investigated. We made use Lyn-/- autoimmune model, generating Cd53-/- mice, compared trafficking immune cells into secondary lymphoid organs disease development with mice lacking either gene alone....
Abstract Cell death frequently occurs in the pathogenesis of obesity and non-alcoholic fatty liver disease (NAFLD). However, exact contribution core cell machinery to manifestations remains ill-defined. Here, we show via direct comparison mice genetically deficient apoptotic caspase-8 myeloid cells, or essential necroptotic regulators, Receptor-interacting protein kinase-3 (RIPK3) Mixed lineage kinase domain-like (MLKL), that RIPK3-caspase-8 signaling regulates macrophage inflammatory...
<h3>Background and Aims</h3> Systemic Lupus Erythematosus (SLE) is a complex, multifactorial autoimmune disease mediated by the deposition of immune complexes in tissues such as kidney, skin brain, with ensuing inflammatory cascade driving progressive tissue damage dysfunction. Mice lacking Lyn tyrosine kinase (Lyn<sup>-/-</sup> mice) develop an similar to SLE, driven dysregulation system, complex systemic inflammation culminating glomerulonephritis. The gut microbiome has been shown have...
<h3>Background and aims</h3> Systemic Lupus Erythematosus (SLE) is a highly complex, heterogeneous autoimmune disease characterised by circulating self-reactive antibodies that deposit in tissues including skin, kidneys brain, alongside chronic inflammatory response leads to progressive tissue damage impaired function. Genome-wide association studies have identified number of receptors signal transduction molecules specific for the immune system predispose development SLE. A loss-of-function...