A5008446646- Neonatal Respiratory Health Research
- Retinopathy of Prematurity Studies
- Parasites and Host Interactions
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Clostridium difficile and Clostridium perfringens research
- Congenital Diaphragmatic Hernia Studies
- Neuroscience of respiration and sleep
- Gut microbiota and health
- Doctoral Education Challenges and Solutions
- Parasite Biology and Host Interactions
- Eosinophilic Esophagitis
- Cytokine Signaling Pathways and Interactions
- Lung Cancer Treatments and Mutations
- Parasitic Infections and Diagnostics
- Pediatric health and respiratory diseases
- Infant Nutrition and Health
- Respiratory Support and Mechanisms
- Antimicrobial Peptides and Activities
- Parasitic Diseases Research and Treatment
- Preterm Birth and Chorioamnionitis
- Neonatal Health and Biochemistry
- IL-33, ST2, and ILC Pathways
- Child Nutrition and Feeding Issues
- Neuroendocrine regulation and behavior
The Alfred Hospital
2020-2024
Monash University
2019-2024
Monash Alfred Psychiatry Research centre
2023
Soil-transmitted helminths cause widespread disease, infecting ~1.5 billion people living within poverty-stricken regions of tropical and subtropical countries. As adult worms inhabit the intestine alongside bacterial communities, we determined whether microbiota impacted on host resistance against intestinal helminth infection. We infected germ-free, antibiotic-treated specific pathogen-free mice, with Heligmosomoides polygyrus bakeri. Mice harboured increased parasite numbers in absence a...
The epidemiological patterns of incident chronic obstructive pulmonary disease (COPD) and lung adenocarcinoma are changing, with an increasing fraction occurring in patients who never-smokers or were not exposed to traditional risk factors. However, causative mechanism(s) obscure. Overactivity Src family kinases (SFKs) myeloid cell-dependent inflammatory epithelial endothelial damage independent candidate mechanisms, but their pathogenic convergence has been demonstrated. Here we present a...
Recent advances in the field of host immunity against parasitic nematodes have revealed importance macrophages trapping tissue migratory larvae. Protective immune mechanisms rodent hookworm Nippostrongylus brasiliensis (Nb) are mediated, at least part, by IL-4-activated that bind and trap larvae lung. However, it is still not clear how recognize parasite. An vitro co-culture system bone marrow-derived Nb infective was utilized to screen for possible ligand-receptor pair involved macrophage...
Bronchopulmonary dysplasia (BPD), also called chronic lung disease of immaturity, afflicts approximately one third all extremely premature infants, causing lifelong damage. There is no effective treatment other than supportive care. Retinopathy prematurity (ROP), which impairs vision irreversibly, common in BPD, suggesting a related pathogenesis. However, specific mechanisms BPD and ROP are not known. Herein, neonatal mouse hyperoxic model coincident retinopathy was used to screen for...
Bronchopulmonary dysplasia (BPD) is a severe lung disease that affects preterm infants receiving oxygen therapy. No standardized, clinically-relevant BPD model exists, hampering efforts to understand and treat this disease. This study aimed evaluate confirm candidate of acute chronic BPD, based on exposure neonatal mice high environment during key developmental stages affected in with BPD. Neonatal C57BL/6 mouse pups were exposed 75% from postnatal day (PN)-1 for 5, 8, or 14 days, their...
Intestinal helminth infection triggers a type 2 immune response that promotes ‘weep-and sweep’ characterised by increased mucus secretion and intestinal hypermotility, which function to dislodge the worm from its habitat. Recent studies have discovered several other pathogens cause dysmotility through major alterations enteric nervous systems (ENS), their interactions, within gastrointestinal tract. However, involvement of these has not been investigated for infections. Eosinophils represent...
Abstract Intestinal helminth infection triggers a type 2 immune response that promotes ‘weep-and sweep’ characterised by increased mucus secretion and intestinal hypermotility, which function to dislodge the worm from its habitat. Recent studies have discovered several other pathogens cause dysmotility through major alterations enteric nervous systems (ENS), their interactions, within gastrointestinal tract. However, involvement of these has not been investigated for infections. Eosinophils...
Bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP) are two severe disorders which arise in the lungs eyes preterm infants exposed to prolonged supplemental oxygen. Due lack a clinically relevant animal model simultaneous lung eye disease, shared molecular pathways underlying development these remain unexplored. To address this, we assessed disease oxygen widely used assess ROP. Neonatal C57Bl/6 mice were (75% oxygen) for 5 days from postnatal day (PN) 7 until PN12,...
Bronchopulmonary Dysplasia (BPD) is a debilitating lung condition that commonly affects infants born premature (less than 37 weeks of normal pregnancy). Despite observation increased inflammation in the lungs human and mouse neonates, little research has been conducted on whether this damage driven by growth survival factor granulocytes, G-CSF (granulocyte colony stimulating factor). Using mice absent G-CSF, we have shown free exposed to same conditions as babies are protected against...