A5006808706- Parasites and Host Interactions
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Helicobacter pylori-related gastroenterology studies
- Clostridium difficile and Clostridium perfringens research
- Eosinophilic Esophagitis
- Parasitic Diseases Research and Treatment
- Asthma and respiratory diseases
- CAR-T cell therapy research
- Vibrio bacteria research studies
- Parasite Biology and Host Interactions
- Adipokines, Inflammation, and Metabolic Diseases
- Mycobacterium research and diagnosis
- Clinical Nutrition and Gastroenterology
- Child Nutrition and Feeding Issues
- Antimicrobial Resistance in Staphylococcus
- Wound Healing and Treatments
- Helminth infection and control
- Probiotics and Fermented Foods
- Galectins and Cancer Biology
- Antimicrobial Peptides and Activities
- Neuroendocrine regulation and behavior
- Toxin Mechanisms and Immunotoxins
- Antibiotic Resistance in Bacteria
- Immune cells in cancer
The Alfred Hospital
2021-2024
Monash University
2019-2024
Foundation for laboratory medicine
2024
Boehringer Ingelheim (Germany)
2024
Australian Regenerative Medicine Institute
2024
Boehringer Ingelheim (Switzerland)
2023
Monash Alfred Psychiatry Research centre
2023
École Polytechnique Fédérale de Lausanne
2020-2022
Creative Commons
2020
University of Lausanne
2013-2016
In 2006, 0.6% of healthy subjects living in the Paris area had extended-spectrum β-lactamase (ESBL)-producing Escherichia coli their gut. To assess evolution this rate, a study identical to that 2006 was conducted 2011. Healthy adults who visited IPC check-up centre February–March 2011 and agreed participate, provided stools answered questionnaire on visit day. Stools were analysed detect ESBL producers isolate dominant E. population. ESBLs molecularly characterized. For harbouring...
Hookworms cause a major neglected tropical disease, occurring after larvae penetrate the host skin. Neutrophils are phagocytes that kill large pathogens by releasing neutrophil extracellular traps (NETs), but whether they target hookworms during skin infection is unknown. Using murine hookworm, Nippostrongylus brasiliensis, we observed neutrophils being rapidly recruited and deploying NETs around skin-penetrating larvae. depletion or NET inhibition altered behavior enhanced number of adult...
Macrophages play a critical role in intestinal wound repair. However, the mechanisms of macrophage-assisted repair remain poorly understood. We aimed to characterize more clearly activities murine and human macrophages. Murine macrophages were differentiated from bone marrow cells monocytes isolated peripheral blood mononuclear healthy donors (HD) or Crohn's disease (CD) patients mucosa HD. In-vitro models used study found that both able promote epithelial vitro. This function was mainly...
Soil-transmitted helminths cause widespread disease, infecting ~1.5 billion people living within poverty-stricken regions of tropical and subtropical countries. As adult worms inhabit the intestine alongside bacterial communities, we determined whether microbiota impacted on host resistance against intestinal helminth infection. We infected germ-free, antibiotic-treated specific pathogen-free mice, with Heligmosomoides polygyrus bakeri. Mice harboured increased parasite numbers in absence a...
The WalKR two-component system, controlling cell wall metabolism, is highly conserved among Bacilli and essential for viability. In Staphylococcus aureus, walR walK are followed by three genes of unknown function: walH, walI walJ. Sequence analysis transcript mapping revealed a unique genetic structure this locus in S. aureus: the last gene locus, walJ, transcribed independently, whereas transcription tetra-cistronic walRKHI operon occurred from two independent promoters located upstream...
Despite the proven ability of immunization to reduce Helicobacter infection in mouse models, precise mechanism protection has remained elusive. In this study, we evaluated role inflammatory monocytes vaccine-induced reduction felis infection. We first showed by using flow cytometric analysis that Ly6C(low) major histocompatibility complex class II-positive chemokine receptor type 2 (CCR2)-positive CD64(+) accumulate stomach mucosa during H. To determine whether played a protection, these...
Recent advances in the field of host immunity against parasitic nematodes have revealed importance macrophages trapping tissue migratory larvae. Protective immune mechanisms rodent hookworm Nippostrongylus brasiliensis (Nb) are mediated, at least part, by IL-4-activated that bind and trap larvae lung. However, it is still not clear how recognize parasite. An vitro co-culture system bone marrow-derived Nb infective was utilized to screen for possible ligand-receptor pair involved macrophage...
SUMMARY Intestinal homeostasis following postnatal microbial colonization requires the coordination of multiple processes including activation immune cells, cell-cell communication, controlled deposition extracellular matrix, and epithelial cell turnover differentiation. The intestine harbors largest frequency resident eosinophils all homeostatic organs, yet functional significance eosinophil recruitment to this organ has long remained enigmatic. Eosinophils are equipped both respond to,...
Abstract Macrophage polarization by type-2 cytokines is central to anti-helminth immunity and tissue repair. While some hallmark changes in macrophages are well-characterized associated with protection against helminths, it still unclear how exert their effects. In this context, we investigated Arachidonate 15-lipoxygenase (Alox15), a lipoxygenase well known for its role macrophage the context of metabolic diseases, (M2) human polarization. We show that absence Alox15, M2 cannot trap kill...
Immune check-point blockade (ICB) has revitalized cancer immunotherapy, showing unprecedented efficacy despite only a narrow number of indications and with limited long-term protection. Cancer vaccines are promising combination partners for ICB to widen the patient population profiting from these treatments. Therapeutic heterologous prime-boost vaccination KISIMA
Intestinal helminth infection triggers a type 2 immune response that promotes ‘weep-and sweep’ characterised by increased mucus secretion and intestinal hypermotility, which function to dislodge the worm from its habitat. Recent studies have discovered several other pathogens cause dysmotility through major alterations enteric nervous systems (ENS), their interactions, within gastrointestinal tract. However, involvement of these has not been investigated for infections. Eosinophils represent...
Abstract Type 2 immune cells are key to the maintenance of healthy adipose tissue, however cues responsible for establishment and type two remain unclear. Rana et al. report a specialized stromal cell produces interleukin-33 (IL-33) that activates group innate lymphoid (ILC2s). Activated ILC2s in turn produce cytokines elicit further IL-33 production by stroma positive feedback loop maintains network within visceral tissue (VAT).
Abstract Intestinal helminth infection triggers a type 2 immune response that promotes ‘weep-and sweep’ characterised by increased mucus secretion and intestinal hypermotility, which function to dislodge the worm from its habitat. Recent studies have discovered several other pathogens cause dysmotility through major alterations enteric nervous systems (ENS), their interactions, within gastrointestinal tract. However, involvement of these has not been investigated for infections. Eosinophils...
Hookworm infections cause a neglected tropical disease (NTD) affecting ~740 million people worldwide, principally those living in disadvantaged communities. Infections can high morbidity due to their impact on nutrient uptake and need feed host blood, resulting loss of iron protein, which lead severe anaemia impaired cognitive development children. Currently, only one drug, albendazole is efficient treat hookworm infection the scientific community fears rise resistant strains. As part...
<h3>Background</h3> PD1<sup>+</sup> CD38+ CD8 T-Cells have been shown to be induced during α-PD1 treatment, and show an inverse correlation with therapeutic response in melanoma patients. Additionally, Two Clinical trials recently investigated the potential of α-CD38 enhance PD1/PDL-1 blockade therapy a variety solid tumors based on CD38 contribute adenosine signaling mediated inhibition T cells, or increase expression following PD1/PD-L1 blockade. Both NCT03367819 NCT03637764 utilized...