A5068329611- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Gut microbiota and health
- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- IL-33, ST2, and ILC Pathways
- Parasites and Host Interactions
- Tryptophan and brain disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Eosinophilic Esophagitis
The Alfred Hospital
2024
Monash University
2022-2024
University of Manchester
2022
Manchester Academic Health Science Centre
2022
Intestinal helminth infection triggers a type 2 immune response that promotes ‘weep-and sweep’ characterised by increased mucus secretion and intestinal hypermotility, which function to dislodge the worm from its habitat. Recent studies have discovered several other pathogens cause dysmotility through major alterations enteric nervous systems (ENS), their interactions, within gastrointestinal tract. However, involvement of these has not been investigated for infections. Eosinophils represent...
Abstract Eosinophils are key contributors to allergic pathology, however, increasingly eosinophils described have important roles in organ health and immunoregulation. Factors that impact these diverse functions of not understood. Here we show allergic-type lung inflammation, metabolically distinct populations can be identified based on expression Siglec-F (Siglec-F hi int ). Notably, the population was responsive commensal microbiome, expressing short-chain fatty acid receptor GPR109A....