A5055701586- Gestational Diabetes Research and Management
- Inflammasome and immune disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Retinal Imaging and Analysis
- interferon and immune responses
- Diabetic Foot Ulcer Assessment and Management
- Diabetes and associated disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Cell death mechanisms and regulation
- Natural Antidiabetic Agents Studies
- Retinal Diseases and Treatments
- Pharmacology and Obesity Treatment
- Thyroid Disorders and Treatments
- Autoimmune and Inflammatory Disorders Research
- Diabetes Management and Research
- Phagocytosis and Immune Regulation
- Gut microbiota and health
- Probiotics and Fermented Foods
- Regulation of Appetite and Obesity
- NF-κB Signaling Pathways
- Vitamin D Research Studies
- Gout, Hyperuricemia, Uric Acid
- Bariatric Surgery and Outcomes
- Iron Metabolism and Disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
Walter and Eliza Hall Institute of Medical Research
2013-2024
The University of Melbourne
2019-2024
Mazandaran University of Medical Sciences
2024
Diabetes Research Center
2008-2013
Shahid Sadoughi University of Medical Sciences and Health Services
2008-2013
Yazd University
2007-2012
Abstract RIPK3 and its substrate MLKL are essential for necroptosis, a lytic cell death proposed to cause inflammation via the release of intracellular molecules. Whether how might drive in manner independent lysis remains unclear. Here we show that following LPS treatment, or LPS-induced TLR adaptor protein TRIF inhibitor apoptosis proteins (IAPs: X-linked IAP, cellular IAP1 IAP2) regulate ubiquitylation. Hence, when IAPs absent, triggers activate caspase-8, promoting NLRP3–caspase-1...
Abstract Background This study was performed to assess the prevalence of dry eye syndrome and diabetic retinopathy (DR) in type 2 patients their contributing factors. Methods 199 referred Yazd Diabetes Research Center were consecutively selected. All Subjects assessed by questionnaire about other diseases drugs. Dry with Tear break up time tests Schirmer. subjects underwent indirect ophthalmoscopy retinal color photography. DR graded according early Treatment Diabetic Retinopathy (ETDRS)...
Background: Vitamin D deficiency has long been suspected as a risk factor for glucose intolerance. This study compared serum levels of 25‐hydroxy vitamin 3 in pregnant women with gestational diabetes mellitus (GDM), impaired tolerance (IGT), and non‐GDM control subjects. Methods: In this case‐control study, 54 diagnosed GDM 39 IGT (1 abnormal oral test) were 111 whom excluded by challenge test. Controls matched age, body mass index groups. Results: Maternal concentration groups at 24–28...
The pyroptotic cell death effector gasdermin D (GSDMD) is required for murine models of hereditary inflammasome-driven, IL-1β-dependent, autoinflammatory disease, making it an attractive therapeutic target. However, the importance GSDMD more common conditions mediated by pathological IL-1β activation, such as gout, remain unclear. In this study, we address whether and recently described inhibitor necrosulfonamide (NSA) contribute to monosodium urate (MSU) crystal-induced death, release,...
Interleukin-1β (IL-1β) is activated by inflammasome-associated caspase-1 in rare autoinflammatory conditions and a variety of other inflammatory diseases. Therefore, IL-1β activity must be fine-tuned to enable anti-microbial responses whilst limiting collateral damage. Here, we show that precursor rapidly turned over the proteasome this correlates with its decoration K11-linked, K63-linked K48-linked ubiquitin chains. The ubiquitylation not just degradation signal triggered inflammasome...
Type 2 diabetes is a common disorder that recognized as major health problem in Iran. Diabetes cause of morbidity, mortality, and economic burden to the society. Some people believe smoking opium can reduce serum glucose lipids mellitus. This study was designed compare blood addicts with non-addicts among patients type diabetes.In this case, control subjects were chosen from diabetic patients. Twenty-three males addicted selected case group, 46 no addiction opioid drugs group. Blood Sugar...
Skin problems caused by neuropathy and antipathy are common manifestations of diabetes. The most serious about such problem is the diabetic foot, which may lead to eventual ulceration amputation, will decrease a patient's quality life dramatically.The aim this study assess level foot self-care conditions in patients, demonstrate role education care.A total 80 patients were included study, all whom had referred "Yazd Diabetic Research Center." levels their recorded pre-test questionnaires,...
The aim of this study was to evaluate fasting serum leptin concentration and its relation insulin resistance in women with gestational diabetes mellitus (GDM) impaired glucose tolerance (IGT). This case-control study, at 28 weeks gestation, measured leptin, insulin, homeostatic model assessment index three groups, GDM, IGT, normal control, compared them each other. level significantly higher GDM than the two other groups (p = 0.03). In positively related (r 0.221, p 0.03) 0.246, 0.03),...
Adiponectin is an insulin sensitizing protein. Because gestational diabetes mellitus associated with resistance, we compared serum adiponectin levels in women and healthy pregnant women.Twenty-nine 26 impaired glucose tolerance were 27 normal control group. Controls matched for age, age body mass index (BMI) before pregnancy two other groups. At 28 weeks of gestation concentration adiponectin, resistance (calculated by the homeostasis model assessment) measured three groups.The level...
To study the 4 years incidence of diabetic retinopathy in patients with type II diabetes and effective factors on its progression.Among referred to Yazd Diabetes Research Center, 120 without were selected. After complete ophthalmic examination, fasting blood sugar (FBS), postprandial sugar, triglyceride, cholesterol measured height, weight, pressure (BP) recorded. Then followed eye examination yearly for years.Four-year cumulative was 47.5% (95% CI: 38.6-56.4). The mild nonproliferative...
OBJECTIVE To assess the incidence and trend of metabolic syndrome phenotype in adolescents from Tehran Lipid Glucose Study during 3.6 years follow-up. RESEARCH DESIGN AND METHODS A total 932 adolescents, aged 10–19 years, who had complete data returned for reassessment later were investigated. RESULTS Prevalence at baseline after was 7.4 6.7%, respectively, based on Adult Treatment Panel (ATP) III definitions; 3.5 8.0%, International Diabetes Federation (IDF) 4.1 9.4%, American Heart...
This study was performed to estimate prevalence of transaminase levels in type 2 diabetic patients and identify contributing risk factors. In this cross-sectional 348 with diabetes, who attended the clinic Yazd Diabetes Research Center, were studied from October 2004 December 2005. Patients history viral hepatitis, alcohol abuse use drug such as Amiodarone, Bleomycin, methotrexate, tamoxifen sodium valporate excluded. To examine relationships between ALT, AST individuals II diabetes relation...
Pathogen recognition and TNF receptors signal via receptor interacting serine/threonine kinase-3 (RIPK3) to cause cell death, including MLKL-mediated necroptosis caspase-8-dependent apoptosis. However, the post-translational control of RIPK3 is not fully understood. Using mass-spectrometry, we identified that ubiquitylated on K469. The expression mutant K469R demonstrated ubiquitylation can limit both RIPK3-mediated apoptosis necroptosis. enhanced death overexpressed activated endogenous...
Wolfram syndrome is the constellation of juvenile onset diabetes mellitus and optic atrophy, known as DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, Deafness).Patients demonstrate followed by atrophy in first decade, insipidus sensorineural deafness second dilated renal outflow tracts early third multiple neurological abnormalities fourth decade.This study reports two siblings with late diagnosed wolfram insipidus, mellitus, severe urological abnormalities.In conclusion,...
Cell death frequently occurs in the pathogenesis of obesity and metabolic dysfunction-associated fatty liver disease (MAFLD). However, exact contribution core cell machinery to manifestations remains ill-defined. Here, we show via direct comparison mice genetically deficient essential necroptotic regulators, receptor-interacting protein kinase-3 (RIPK3) mixed lineage kinase domain-like (MLKL), as well lacking apoptotic caspase-8 myeloid cells combined with RIPK3 loss, that RIPK3/caspase-8...