A5003695284- Migraine and Headache Studies
- Neuroscience of respiration and sleep
- Phytochemicals and Antioxidant Activities
- Neuroscience and Neuropharmacology Research
- Meteorological Phenomena and Simulations
- Trigeminal Neuralgia and Treatments
- Adenosine and Purinergic Signaling
- Ion Channels and Receptors
- Cryospheric studies and observations
- Plant Molecular Biology Research
- Neurological Disorders and Treatments
- Advanced Sensor and Energy Harvesting Materials
- Climate change and permafrost
- Pain Mechanisms and Treatments
- Teratomas and Epidermoid Cysts
- Arctic and Antarctic ice dynamics
- Circadian rhythm and melatonin
- Functional Brain Connectivity Studies
- Nicotinic Acetylcholine Receptors Study
- Conducting polymers and applications
- Remote Sensing and Land Use
- Sympathectomy and Hyperhidrosis Treatments
- Photoreceptor and optogenetics research
- Climate variability and models
- Remote-Sensing Image Classification
Xi’an Jiaotong-Liverpool University
2013-2024
Xidian University
2024
Chinese Academy of Forestry
2020-2024
University of Liverpool
2021-2024
Nanjing University of Information Science and Technology
2024
Women's Hospital, School of Medicine, Zhejiang University
2022-2024
Research Institute of Forestry
2023
China Meteorological Administration
2010-2023
Jiangxi University of Traditional Chinese Medicine
2023
Sun Yat-sen University
2022
Fog is a severe weather hazard that greatly influences traffic and daily life with potentially heavy economic loss. An increasing number of accidents caused by fog have been reported in China recent years. In this study, we show the frequencies events wintertime over eastern‐central doubled past three decades. For same period, surface wind speeds dropped from 3.7 m/s to about 3 mean cold air outbreaks has decreased 7 around 5 times per winter; relative humidity frequency light also increased...
Atmospheric reanalysis reproduces the past atmospheric conditions through assimilation of historical meteorological observations with fixed version a numerical weather prediction (NWP) model and data (DA) system. It is widely used in weather, climate, even business-related research applications. This paper reports development CMA's first-generation global (RA) covering 1979–2018 (CRA-40; CRA refers to CMA-RA). CRA-40 produced by using Global Spectral Model (GSM)/Gridpoint Statistical...
Abstract Oscillatory synchronization between somatosensory and motor cortex has previously been reported using field potential recordings, but interpretation of such results can be confounded by volume conduction. We examined coherence single‐unit discharge in somatosensory/parietal areas local from the same area as unit, or cortex, two macaque monkeys trained to perform a finger movement task. There were clear peaks at ∼17.5 Hz for cells primary (both proprioceptive cutaneous areas)...
The transient receptor potential ankyrin A 1 (TRPA1) channel and calcitonin gene-related peptide (CGRP) are targets for migraine prophylaxis. This study aimed to understand their mechanisms in by investigating the role of TRPA1 cortical spreading depression (CSD) vivo exploring how reactive oxygen species (ROS)/TRPA1/CGRP interplay regulating susceptibility CSD.Immunohistochemistry was used detecting expression. CSD induced K+ on cerebral cortex, monitored using electrophysiology rats,...
The neuropeptide calcitonin gene-related peptide (CGRP) has now been established as a key player in migraine. However, the mechanisms underlying reported elevation of CGRP serum and cerebrospinal fluid some migraineurs are not known. A candidate mechanism is cortical spreading depression (CSD), which associated with migraine aura traumatic brain injury. aim this study was to investigate whether gene expression may be induced by experimental CSD rat cerebral cortex.CSD topical application KCl...
Thioredoxin reductase (TR) can help pathogens resist oxidative-burst injury from host immune cells by maintaining a thioredoxin-reduction state during NADPH consumption. TR is necessary virulence factor that enables the persistent infection of some parasites. We performed bioinformatics analyses and biochemical assays to characterize activity, subcellular localization, genetic ablation Toxoplasma gondii (TgTR), shed light on its biologic function. expressed TgTR protein with an Escherichia...
Both exotic and native plant invasions can have profound impacts on ecosystems. While many studies examined the effects of soil properties, relatively few tested microbial communities. Furthermore, we know little about communities in litter. In subtropical forests southern China, sampled litter at three decomposition stages top forest sands representing invasion (not invaded, moderately heavily invaded) by Moso bamboo (Phyllostachys edulis (Carriere) J. Houzeau), a species China. We measured...
Background: Palmitoyl ethanol amide (PEA) is an endogenously produced substance showing anti-nociceptive effect through both receptor and non-receptor mediated effects at the level of different cellular tissue sites. This study showed results a single blind that was conducted to evaluate safety efficacy ultramicronized PEA (umPEA; 1,200 mg/day) for up 90 days in patients suffering Migraine with Aura (MA) treated NSAIDs. Methods: A total 20 patients, 8 male (33-56-years, average 41.4 ± 7.8)...
Objective: Volatile anesthetic such as isoflurane causes widespread neurodegeneration in the developing animal brains and also induces cognitive impairments. Paeonol is a plant-derived phenolic compound possessing numerous bioactive properties. The study investigates neuroprotective effects of paeonol against isoflurane-induced disturbances neonatal rats.Methods: (50, 100, 150 mg/kg body weight/day) was given orally to separate groups rats from postnatal day 3 (P3) P21 were exposed (0.75%; 6...
Src family kinases (SFK) are a group of non-receptor tyrosine which play pivotal role in cellular responses and oncogenesis. Accumulating evidence suggest that SFK also act as key component signalling pathways the central nervous system (CNS) both physiological pathological conditions. Despite crucial signal transduction CNS, relationship between molecules implicated pain has been relatively unexplored. This article briefly reviews recent advances uncovering interplay with diverse membrane...
Cortical spreading depression (CSD) is a propagating wave of depolarization followed by cortical activity. CSD triggers neuroinflammation via the pannexin-1 (Panx1) channel opening, which may eventually cause migraine headaches. However, regulatory mechanism Panx1 unknown. This study investigates whether sarcoma family kinases (SFK) are involved in transmitting CSD-induced activation, mediated NR2A-containing N-methyl-D-aspartate receptor. was induced topical application K+ to cerebral...
The communication between calcitonin gene-related peptide (CGRP) and cytokines plays a prominent role in maintaining trigeminal ganglion (TG) trigeminovascular sensitization. However, the underlying regulatory mechanism is elusive. In this study, we explored hypothesis that Src family kinases (SFKs) activity facilitates crosstalk CGRP sensitizing TG. Mouse TG tissue culture was performed to study release by enzyme-linked immunosorbent assay, cytokine multiplex gene expression quantitative...
Cortical spreading depression (CSD) is a temporary disruption of local ionic homeostasis that propagates slowly across the cerebral cortex. promotes lesion progression in experimental stroke, and may contribute to initiation migraine attacks. The purpose this study was investigate roles marked increase nitric oxide (NO) formation occurs with CSD. Microdialysis electrodes were implanted cortex anesthetized rats perform following operations within same region: (1) elicitation CSD by perfusion...
Spreading depression (SD) is a local, temporary disruption of cellular ionic homeostasis that propagates slowly across the cerebral cortex and other neural tissues such as retina. depolarization associated with SD occurs in different types stroke, this phenomenon correlates also initiation classical migraine aura. The aim study was to investigate how NMDA receptor antagonists subtype selectivity alter SD.Immunoblotting applied chick retina for subunit protein analysis, an efficient vitro...
Abstract Cortical spreading depression (CSD) is a transient propagating excitation of synaptic activity followed by depression, which implicated in migraine. Increasing evidence points to an essential role NR2A-containing NMDA receptors CSD propagation vitro ; however, whether these mediate genesis vivo requires clarification and the NR2A on still under debate. Using rats with electrophysiology chick retina intrinsic optical imaging, we addressed CSD. We demonstrated that NVP-AAM077, potent...
Purinergic P2X7 receptor plays an important role in migraine pathophysiology. Yet precise molecular mechanism underlying P2X7R signaling remains unclear. This study explores the hypothesis that transmits to Src family kinases (SFKs) during cortical spreading depression (CSD) and neuroinflammation after CSD.
Electric-assisted capillary rise adsorption of polar and nonpolar solvents by cellulose chitosan was studied employing an electrostatic generator to assist a common wetting taking the anode cathode electrodes respectively linked metal tube charged with samples probe solvent. To vary voltage at 0, 100, 200, 300 V, respectively, recorded dynamic results showed that both kept stable hexane diiodomethane, obviously ignoring increase. Moreover, amount adsorbed is similar, while diiodomethane...