A5064352910- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Ophthalmology and Eye Disorders
- Cerebral Venous Sinus Thrombosis
- Pituitary Gland Disorders and Treatments
- Natural product bioactivities and synthesis
- Lung Cancer Research Studies
- Retinal and Optic Conditions
- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer, Hypoxia, and Metabolism
- Neonatal and fetal brain pathology
- Pharmacological Effects of Natural Compounds
- Polymer Nanocomposites and Properties
- GABA and Rice Research
- Brain Metastases and Treatment
- Phytochemicals and Antioxidant Activities
- Corneal surgery and disorders
- biodegradable polymer synthesis and properties
- Ubiquitin and proteasome pathways
- Dyeing and Modifying Textile Fibers
- Retinopathy of Prematurity Studies
- Methane Hydrates and Related Phenomena
University of South China
2025
Sun Yat-sen University
2014-2024
Sun Yat-sen Memorial Hospital
2017-2024
Sichuan University
2018-2023
Yichang Central People's Hospital
2022
China Three Gorges University
2022
Northwest Normal University
2021
Northwestern Polytechnical University
2021
Nanjing Agricultural University
2015-2020
Second Affiliated Hospital of Nanchang University
2014-2019
Background Tongmai Yangxin Pills (TMYXP) is a well-known traditional Chinese medicine compound to treat coronary heart disease (CHD). Aging key immutable independent risk factor for CHD. Currently, there are few gene expression profiles of patients treated with (TCM) or TCM compound. However, the chemical composition and underlying mechanisms TMYXP against elderly CHD need be elucidated. Objective Exploring mechanism in treating based on human profiles, find pharmacodynamic ingredients...
HER2 (human epidermal growth factor receptor 2) activation is critical in breast cancer development. promotes cell proliferation, angiogenesis, survival, and metastasis by of PI3K/Akt, Ras/MEK/ERK, JAK/STAT pathways. However, beyond these signaling molecules, the key proteins underlining HER2-mediated remain elusive. ATF4 (Activating transcription 4), a regulator unfolded protein response (UPR), implicated migration tumor metastasis. In this study, we demonstrate that upregulated expression...
C-glycosylflavonoids are characterized by a bond between the anomeric carbon of sugar moiety and C-6 or C-8 position flavonoid A ring. These compounds widespread in nature have become subject increasing research interest due to their high biological potential. This review focuses on effects various structure–activity relationships (SAR) as elucidated over last 5 years.
Thioredoxin reductase (TR) can help pathogens resist oxidative-burst injury from host immune cells by maintaining a thioredoxin-reduction state during NADPH consumption. TR is necessary virulence factor that enables the persistent infection of some parasites. We performed bioinformatics analyses and biochemical assays to characterize activity, subcellular localization, genetic ablation Toxoplasma gondii (TgTR), shed light on its biologic function. expressed TgTR protein with an Escherichia...
The effects of Bone morphogenetic protein 2 (BMP-2) on the angiogenesis hepatocellular carcinoma have not yet been observed and its molecular mechanisms is clear. We first constructed recombinant lentivirus vectors expressing small hairpin RNA against BMP-2 gene (LV-SH-BMP2) over-expressing (overexpression-LV-BMP2), then two were respectively transfected into Hep G2 cells. cells with LV-SH-BMP2 or overexpression-LV-BMP2 co-cultured human umbilical vein endothelial (HUVECs) to observe HUVECs....
To evaluate the disease burden of glaucoma in terms disability-adjusted life years (DALY) and assess contribution risk factors to DALY due glaucoma.Global, regional, country number, rate, age-standardized rates were obtained from Global Burden Disease Study 2017 database. The Human Development Index (HDI), Inequality-Adjusted HDI, Socio-Demographic (SDI), other country-level data derived international open databases. Regression analysis was used correlations between rate variables.The global...
To study the clinical significance of Graves' orbitopathy-specific quality life (GO-QOL) questionnaire in mainland Chinese patients. A cross-sectional was performed at Ophthalmology Department Sun Yat-sen Memorial Hospital from April 2017 to 2018. Eighty-eight consecutive orbitopathy (GO) patients completed two subscales GO-QOL questionnaire: visual functioning and appearance. The disease severity GO measured by European Group on Orbitopathy (EUGOGO) classification, activity evaluated score...
Purpose. This study aims to explore the risk factors of asthenopia in myopic population. Methods. In this cross-sectional study, myopia patients were inquired about their eye habits and requested complete an questionnaire ocular examinations. Age, gender, occupation, anisometropia, care education, weekly outdoor activity time, duration continuous near work, daily screen dry eye, phoria, binocular accommodative facility calculated using Student’s test-test, Mann Whitney U test, Pearson’s...
To construct a proper model to screen for diabetic retinopathy (DR) with the RETeval. This was cross-sectional study. Two hundred thirty-two patients and seventy controls were recruited. The DR risk assessment protocol performed obtain subjects' score using Afterwards, receiver operating characteristic (ROC) curve used determine best cutoff diagnosing DR. Random forest decision tree models constructed. With increasing severity, gradually increased. When diagnose DR, ROC had an area under of...
AIM: To quantitatively evaluate the effect of combined use 577-nm subthreshold micropulse macular laser (SML) and multi-point mode pan retinal photocoagulation (PRP) on severe non-proliferative diabetic retinopathy (NPDR) with central-involved edema (CIDME) using optical coherence tomography angiography (OCTA). METHODS: In this observational clinical study, 86 eyes NPDR patients CIDME who underwent SML PRP treatment were included. Images obtained 1d before post-laser (1d, 1wk, 1, 3, 6mo)...
Hydrochemistry and Sr isotope compositions were measured in water samples collected during high- low-water periods from the main stream tributaries of Xijiang River Basin southern China. The primary weathering end-members analyzed calculated using multi-model combination classic hydrogeochemical method. During high-water period, structural factors found to be controlling chemical basin, whereas anthropogenic activity other random had a negligible influence. both controlled weathering....
We investigated the therapeutic potential of ABBV744, a bromodomain and extra-terminal (BET) inhibitor with selectivity for second (BD2) in thyroid eye disease (TED). The anti-fibrotic effects ABBV744 its underlying mechanism were explored cultured orbital fibroblasts (OFs) from patients TED.Immunohistochemistry (IHC) real-time quantitative polymerase chain reaction (RT-qPCR) assays conducted on connective tissues TED controls. RT-qPCR, Western blot, Cell-counting Kit-8 (CCK-8),...
<h3>Importance</h3> Although thoracic twice-daily radiotherapy (TDRT) is one of the standards care for small cell lung cancer, its association with brain metastases remains unknown. <h3>Objective</h3> To investigate TDRT vs once-daily (ODRT) after prophylactic cranial irradiation in patients cancer. <h3>Design, Setting, and Participants</h3> In this multicenter cohort study, data on 778 consecutive cancer who had undergone (609 received ODRT 169 TDRT), chemotherapy, were retrieved from...
To investigate the clinical characteristics of Graves' orbitopathy (GO) with elevated intraocular pressure (IOP) using European Group Orbitopathy (EUGOGO) system.In this retrospective study, data GO patients IOP (≥21 mmHg) were collected in Sun Yat-sen Memorial Hospital from January 2010 to June 2016. The demographic characteristics, history thyroid disease and GO, ocular examination evaluated, activity severity classified.Data 58 eyes 39 patients. durations 15.9 ± 18.9 months 7.5 6.2...