A5057493889- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Visual perception and processing mechanisms
- EEG and Brain-Computer Interfaces
- Single-cell and spatial transcriptomics
- Neural Networks and Applications
- Motor Control and Adaptation
- Hematopoietic Stem Cell Transplantation
- Action Observation and Synchronization
- Behavioral Health and Interventions
- Neuroscience and Neuropharmacology Research
- Mental Health Research Topics
- Cancer Genomics and Diagnostics
- Cognitive Science and Education Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cell Image Analysis Techniques
- Pain Management and Placebo Effect
- Plant and animal studies
Stanford University
2015-2021
Champalimaud Foundation
2015-2019
Howard Hughes Medical Institute
2015
Abstract Neuronal variability in sensory cortex predicts perceptual decisions. This relationship, termed choice probability (CP), can arise from biasing behaviour and top-down signals reflecting behaviour. To investigate the interaction of these mechanisms during decision-making process, we use a hierarchical network model composed reciprocally connected integration circuits. Consistent with monkey fixed-duration motion discrimination task, integrates evidence transiently, giving rise to...
Abstract Dorsal premotor cortex is implicated in somatomotor decisions. However, we do not understand the temporal patterns and laminar organization of decision-related firing rates dorsal cortex. We recorded neurons from monkeys performing a visual discrimination task with reaches as behavioral report. show that these can be organized along bidirectional visuomotor continuum based on task-related rates. “Increased” at one end increased their ~150 ms after stimulus onset covaried...
How deliberation on sensory cues and action selection interact in decision-related brain areas is still not well understood. Here, monkeys reached to one of two targets, whose colors alternated randomly between trials, by discriminating the dominant color a checkerboard cue composed different numbers squares target trials. In Targets First task colored targets appeared first, followed checkerboard; Checkerboard task, this order was reversed. After both tasks, responses dorsal premotor cortex...
Abstract Models of complex heterogeneous systems like the brain are inescapably incomplete, and thus always falsified with enough data. As neural data grow in volume complexity, absolute measures adequacy being replaced by model selection methods that rank relative accuracy competing theories. Selection still depends on incomplete mathematical instantiations, but implicit expectation is ranking robust to their details. Here we highlight a contrary finding “brittleness,” where matching one...
Summary Studies in multiple species have revealed the existence of neural signals that lawfully co-vary with different aspects decision-making process, including choice, sensory evidence supports and reaction time. These signals, often interpreted as representation a decision variable (DV), been identified several motor preparation circuits provide insight about mechanisms underlying process. However, single-trial dynamics this process or its at population level remain poorly understood....
Abstract Purpose. The study aimed to compare social network analysis (SNA) general measures and centrality levels of successful unsuccessful offensive sequences performed by elite national teams in 64 matches the FIFA World Cup 2014 tournament level between playing positions. Methods. Adjacency matrices passing within an unit were built treated a dedicated SNA software. Results. main results indicated significantly lower values total links density comparison with ones that achieved round 8,...
Summary In dynamic environments, subjects often integrate multiple samples of a signal and combine them to reach categorical judgment. The process deliberation on the evidence can be described by time-varying decision variable (DV), decoded from neural activity, that predicts subject’s at end trial. However, within trials, large moment-to-moment fluctuations DV are observed. behavioral significance these their role in remain unclear. Here we show within-trial real time motor cortex tightly...
Single-cell transcriptomics has been widely applied to classify neurons in the mammalian brain, while systems neuroscience historically analyzed encoding properties of cortical without considering cell types. Here we examine how specific transcriptomic types mouse prefrontal cortex (PFC) projection relate axonal projections and across multiple cognitive tasks. We found that most projected targets, targets received from types, except PFC→PAG (periaqueductal gray). By comparing Ca2+-activity...
Summary How deliberation on sensory cues and action selection interact in decision-related brain areas is still not well understood. Here, monkeys reached to one of two targets, whose colors alternated randomly between trials, by discriminating the dominant color a checkerboard cue composed different numbers squares target trials. In “Targets First” task colored targets appeared first, followed checkerboard; “Checkerboard task, this order was reversed. After both tasks, responses dorsal...
SUMMARY Single-cell transcriptomics has been widely applied to classify neurons in the mammalian brain, while systems neuroscience historically analyzed encoding properties of cortical without considering cell types. Here we examine how specific transcriptomic types mouse prefrontal cortex (PFC) projection relate axonal projections and across multiple cognitive tasks. We found that most projected targets, targets received from types, except PFC→PAG (periaqueductal gray). By comparing Ca 2+...