A5054351750- Substance Abuse Treatment and Outcomes
- Alcohol Consumption and Health Effects
- Lung Cancer Treatments and Mutations
- Dermatology and Skin Diseases
- Colorectal Cancer Treatments and Studies
- Nail Diseases and Treatments
- Cancer Genomics and Diagnostics
- Mental Health Research Topics
- Urinary Bladder and Prostate Research
- Lung Cancer Research Studies
- demographic modeling and climate adaptation
- Alcoholism and Thiamine Deficiency
- Contact Dermatitis and Allergies
- Autoimmune Bullous Skin Diseases
- Health, Medicine and Society
- Pain Management and Placebo Effect
- Pharmacological Effects and Toxicity Studies
- Chemotherapy-related skin toxicity
- Diagnosis and Treatment of Venous Diseases
- Homelessness and Social Issues
- Osteoarthritis Treatment and Mechanisms
- Melanoma and MAPK Pathways
- Eicosanoids and Hypertension Pharmacology
- Cutaneous Melanoma Detection and Management
- Pain Mechanisms and Treatments
Janssen (France)
2022-2024
Pierre Fabre (France)
2010-2018
Issy Media (France)
2014-2017
Lundbeck (Denmark)
2014-2015
Gestion de l'Eau, Acteurs, Usages
2012
Pierre Fabre (Germany)
2011
Laboratoire Vision Action Cognition
2011
Abstract Background. Hand–foot syndrome (HFS) is a common reaction to certain chemotherapies and new targeted therapies, impairing patient quality of life (QoL). However, there currently no specific tool measure QoL in patients with HFS. Objective. The objective was develop validate HFS-specific questionnaire (HFS-14). Patients Methods. From list 31 items identified from literature review interview notes, item reduction pilot testing by cognitive debriefing resulted final 14-item excellent...
Abstract Background Among localizations of sensitive skin, scalp is one the less known. Objectives We performed a study for better understanding and proposed new score: 3S score. Methods An opinion poll was conducted on 2117 persons, which were representative French population. The total score obtained by multiplying severity abnormal sensations number these sensations. Results About one‐third population declared to suffer from scalp. It increasingly frequent with age. questionnaire allowed...
Abstract Objectives To investigate the prevalence and factors related to sensitive skin in China. Methods A community‐based study was undertaken three major cities China, Beijing, Shanghai Guangzhou, from November 2009 January 2010. The participants were screened by cluster sampling, investigated interview at their own homes. questionnaire, including sensitivity, occurrence of burning, prickling or irritating sensations correlated with factors, history diseases types, given each participant...
Aims: In patients with alcohol dependence, health-related quality of life (QOL) is reduced compared that a normal healthy population. The objective the current analysis was to describe evolution QOL in adults dependence during 24-month period after initial assessment for alcohol-related treatment routine practice setting, and its relation drinking pattern which evaluated across clusters based on predominant use, set against influence baseline variables Methods: Medical Outcomes Study 36-Item...
Patients with advanced, epidermal growth factor receptor (EGFR)-mutated, non-small cell lung cancer (NSCLC) Exon 20 insertion mutations (Exon20ins) have poor prognoses, exacerbated by a previous lack of specific treatment guidelines and unmet need for targeted therapies. Amivantamab, an EGFR MET bispecific antibody, demonstrated efficacy tolerability in patients advanced EGFR-mutated NSCLC Exon20ins following platinum-based therapy CHRYSALIS (NCT02609776; Cohort D+). Since was single-arm,...
To determine whether nalmefene combined with psychosocial support is cost-effective compared alone for reducing alcohol consumption in alcohol-dependent patients high/very high drinking risk levels (DRLs) as defined by the WHO, and to evaluate public health benefit of harmful alcohol-attributable diseases, injuries deaths.
Background The objective of this article was to investigate the effect as-needed nalmefene on health-related quality life (HRQoL) in patients with alcohol dependence, and relate changes drinking behavior status HRQoL outcomes. Methods This post hoc analysis conducted a pooled subgroup at least high risk level (men: >60 g/day; women: >40 g/day) who participated one two randomized controlled 6-month studies, ESENSE 1 2. Patients received 18 mg or placebo an basis, addition motivational...
On the one hand, survey aims at development and validation of an auto-administered questionnaire designed to measure everyday burden caused by chronic venous disorders (CVDs). other it reporting initial epidemiological demographic data in CVD patients their correlations.After identification 66 possible items, elimination redundant less relevant questions left a 36 simple Assessment Burden Chronic-Venous Disease (ABC-V) that has been applied prospectively consecutively population 328 actual...
Alcohol consumption is one of the most important factors for disease and disability in Europe. In clinical trials, nalmefene has resulted a significant reduction number heavy-drinking days (HDDs) per month total alcohol (TAC) among alcohol-dependent patients versus placebo.A microsimulation model was developed to estimate alcohol-attributable diseases injuries with dependence explore relevance reducing consumption.For all considered, events (inpatient episodes) increased HDDs TAC year. The...
Most available pharmacotherapies for alcohol-dependent patients target abstinence; however, reduced alcohol consumption may be a more realistic goal. Using randomized clinical trial (RCT) data, previous microsimulation model evaluated the relevance of in terms avoided alcohol-attributable events. real-life observational current analysis aimed to adapt and confirm findings about consumption.Based on prospective CONTROL study, evaluating daily among patients, predicted probability drinking any...
This study explores sociocultural differences in alcohol-related impact on quality of life between France and United Kingdom. We included 38 alcohol-dependent patients Kingdom 10 focus groups. used a text-mining approach. Three classes each corpus regarded identical themes across the countries: (a) core life, (b) drinking habits, (c) sources help. Core was similar two countries. Main were habits referral to Despite domains impacted by alcohol non–country specific.
Context and objective: The objective of assessing “quality life” is to take better consideration the patients’ perception their own state health by developing specific measurement tools. Paradoxically, there no questionnaire evaluating impact such treatment on women's quality life. There was, therefore, a need for creation CosmeceutiQoL. Method: was developed using methodology in accordance with international standards terms Results: score CosmeceutiQoL correlated age. more sensitive skin...
Objective: A microsimulation model was adapted to evaluate the cost-effectiveness of nalmefene combined with psychosocial support (NMF + PS) versus alone (PS). The economic impact alcohol reduction using treatment not evaluated. Method: simulates patient-level consumption over a 5-year time horizon across different cohorts. Study outcomes included probabilities alcohol-attributable diseases and injuries as well deaths from these events. approach used clinical trial data, 1 5 years, U.K....
Abstract Although it is a frequent disease, atopic dermatitis poorly recognised and therefore under‐diagnosed. The aim of this study was to define validate convenient tool allowing presumption for non‐dermatologists. A 20‐item questionnaire (PPAD) an 8‐item short version (PPAD‐S) were developed in French by board experts, then tested on outpatients presenting with or not. Diagnosis confirmed dermatologist, who measured the severity disease using SCORAD. PPAD PPAD‐S proved be efficient tools...
To characterize a contemporaneous cohort of UK general practice patients with alcohol use disorder and describe their management. Prospective observational study in 25 primary care practices England Scotland. Adult known or suspected dependence (Alcohol Use Disorders Identification Test score ≥8) were followed for 6 months profiled using baseline data. Changes over time treatment (strategy, goals, modality) the level compliance examined. Targeted case identification was feasible means...
Amivantamab, an EGFR-MET bispecific antibody, is the first approved targeted therapy for patients with EGFR Ex20ins NSCLC after prior platinum-based chemotherapy—a population historically poor outcomes before amivantamab approval. As antitumor activity in single-arm studies typically focuses on responders, evaluation of stable disease (SD) as best response clinical interest. Among 114 post-platinum CHRYSALIS (NCT02609776; data cutoff: March 30, 2021), was assessed by blinded independent...
Patients with advanced non-small cell lung cancer (NSCLC) epidermal growth factor receptor gene (EGFR) Exon 20 insertions (Exon20ins) at the second line and beyond (2L+) have an unmet need for new treatment. Amivantamab, a bispecific EGFR- MET-targeted antibody, demonstrated efficacy in this setting phase 1b, open-label CHRYSALIS trial (NCT02609776). The primary objective was to compare of amivantamab choices made by real-world physicians (RWPC) using external control cohort from evidence...