A5081138437- Muscle metabolism and nutrition
- Adipose Tissue and Metabolism
- Cardiovascular and exercise physiology
- Exercise and Physiological Responses
- Nutrition and Health in Aging
- Sports Performance and Training
- Body Composition Measurement Techniques
- Esophageal Cancer Research and Treatment
- Vitamin D Research Studies
- Agriculture, Soil, Plant Science
- Genetics and Physical Performance
- Radiomics and Machine Learning in Medical Imaging
- Pleural and Pulmonary Diseases
- Pharmacological Effects and Assays
- GDF15 and Related Biomarkers
- Physical Activity and Health
- Child Development and Digital Technology
- Pericarditis and Cardiac Tamponade
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Medical Imaging Techniques and Applications
- Hormonal and reproductive studies
- Muscle Physiology and Disorders
- Dialysis and Renal Disease Management
- Lung Cancer Treatments and Mutations
- Frailty in Older Adults
Johns Hopkins University
2023-2024
Johns Hopkins Medicine
2024
Ball State University
2020-2023
Salisbury University
2017-2021
Harefield Hospital
1989-2004
Mount Vernon Hospital
2004
Louisiana State University Agricultural Center
1979
These longitudinal analyses of six muscle groups in septuagenarians provide novel information on the group-specific aging process. Although quadriceps, hamstrings, psoas, and rectus abdominis atrophied with different magnitudes, lateral abdominals paraspinals hypertrophied over 5 years. findings contribute to a better understanding skeletal process highlight need complete studies this area muscle-specific focus.
This investigation studied DNA, RNA, and protein contents of adipose skeletal muscle tissues from young active individuals. A series optimization steps were investigated to aid in determining the optimal approach extract high-yield high-quality biomolecules. These findings contribute knowledge gap tissue requirements for molecular biology assays, which is increasing importance due growing interest research involving human exercise physiology research.
This study demonstrated that even low-dose aspirin concentrations can significantly reduce the prostaglandin (PG)E 2 /cyclooxygenase (COX) pathway activity in human skeletal muscle and this effect is not altered during recovery period following aerobic exercise. These findings are noteworthy since one of most commonly consumed drugs world nonaspirin COX-inhibiting have been shown to regulate health sedentary exercise-training individuals.
Prostaglandin (PG) E2 has been linked to increased inflammation and attenuated resistance exercise adaptations in skeletal muscle. Nonaspirin cyclooxygenase (COX) inhibitors have shown reduce these effects. This study examined the effect of low-dose aspirin on muscle COX production PGE2 at rest following exercise. Skeletal (vastus lateralis) biopsies were taken from six individuals (4 M/2 W) before 3.5 hr after a single bout for ex vivo under control low (10 μM)- or standard (100 μM)-dose...
Abstract Sarcopenia, the loss of muscle mass and strength, is a major risk factor for physical frailty in older adults. Ca2+/calmodulin-dependent protein kinase II (CaMKII) activated by Ca2+ reactive oxygen species contracting muscles to enhance performance adaptation exercise training. We assessed CaMKII activity skeletal young (4-month-old) old (20-month-old) C57BL/6J mice found significantly increased at rest, suggesting that chronically elevated disconnected from contractile aged...
4056 Background: Neoadjuvant chemotherapy using two cycles of cisplatin and 5FU is standard practice in the UK patients with potentially operable cancer esophagus. The role FDG-PET scanning predicting response to this was assessed. Method: Twenty-three disease at presentation underwent as OEO2 trial protocol. performed before chemotherapy, again after second cycle seventeen patients. Two independent assessors, who were unaware histopathological results, assessed percentage change tumour SUV...
Abstract Aspirin is one of the most commonly consumed cyclooxygenase (COX)‐inhibitors and anti‐inflammatory drugs has been shown to block COX‐produced regulators inflammation aging skeletal muscle size. We used propensity score matching compare characteristics individuals from Health ABC study that did not consume aspirin or any other COX‐inhibiting (non‐consumers, n = 497, 74 ± 3 year, 168 9 cm, 75.1 13.8 kg, 33.1 7.4% body fat, 37% women, 34% black) those daily (and drugs) for at least 1...
4056 Background: Neoadjuvant chemotherapy using two cycles of cisplatin and 5FU is standard practice in the UK patients with potentially operable cancer esophagus. The role FDG-PET scanning predicting response to this was assessed. Method: Twenty-three disease at presentation underwent as OEO2 trial protocol. performed before chemotherapy, again after second cycle seventeen patients. Two independent assessors, who were unaware histopathological results, assessed percentage change tumour SUV...
BACKGROUND: Resistance exercise provides an effective stimulus for improving the metabolic plasticity of skeletal muscle, and type acute muscle contraction plays important role in determining specific responses adaptations. The purpose current investigation was to examine effect order on by comparing monophasic concentric eccentric squats versus a protocol incorporating alternated repetitions.METHODS: Twelve recreationally active men (21.1±1.1yr) performed three nearly identical squat...
This study highlights the feasibility of key aspects MoTrPAC adult human clinical protocols. initial preview what can be expected from acute exercise trial data provides an impetus for scientists to design studies interlace with rich phenotypic and -omics that will populate DataHub at completion parent protocol.
Abstract The metabolic and inflammatory cytokine growth-differentiation factor 15 (GDF15) increases with age negatively associates physical cognitive function in older adults. We hypothesized GDF15 also resilient outcomes after surgery. This hypothesis was tested the SPRING study of resiliency total knee replacement by assessing relationships between pre-operative plasma levels postoperative resilience measures including short performance battery (SPPB) scores, fatigability, grip strength....
PURPOSE: Previous studies have found the energy cost of eccentric exercise to be approximately 1/7 1/4 that concentric exercise, but no study has directly compared concentric–and eccentric–only resistance exercise. Therefore, we expenditure between squats performed with or muscle actions. METHODS: 12 healthy men (20.9±1.1yrs) a BMI<26 three protocols once weekly designed compare different actions: (CON), (ECC), and trial incorporating both (BOTH). Subject’s 1RM was determined using...
Abstract Most of the scientific literature on human skeletal muscle aging has focused quadriceps femoris, with remaining few hundred muscles receiving limited specific investigation. This longitudinal investigation compared changes in size via computed tomography (rectus vastus lateralis, medialis, intermedius), hamstrings (biceps femoris short and long heads, semitendinosus, semimembranosus), psoas, rectus abdominis, lateral abdominals (obliques transversus abdominus), paraspinal (erector...
Abstract Aspirin is one of the most commonly consumed cyclooxygenase (COX)-inhibitors and anti-inflammatory drugs may provide insight into control age-related skeletal muscle atrophy. This investigation compared size (via computed tomography) older individuals from Health ABC study that did not consume aspirin or any other COX-inhibiting drug (non-consumers; n=1,155, 74±3y, 48% women, 45% black) to those daily (and drug) for at least year (aspirin consumers; n=515, 39% 30% black, average...