A5100613895- Retinal Diseases and Treatments
- CAR-T cell therapy research
- Ophthalmology and Visual Impairment Studies
- Cancer Immunotherapy and Biomarkers
- Corneal surgery and disorders
- Glaucoma and retinal disorders
- CRISPR and Genetic Engineering
- Intraocular Surgery and Lenses
- SARS-CoV-2 and COVID-19 Research
- Cancer Cells and Metastasis
- Retinal Imaging and Analysis
- Immunotherapy and Immune Responses
- Hemoglobinopathies and Related Disorders
- COVID-19 Clinical Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Ocular Infections and Treatments
- Retinopathy of Prematurity Studies
- Cerebral Venous Sinus Thrombosis
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- Neonatal Health and Biochemistry
- Prostate Cancer Treatment and Research
- Virus-based gene therapy research
- Immune Cell Function and Interaction
- Ophthalmology and Visual Health Research
University of California, San Francisco
2003-2025
Incyte (United States)
2024
University of California System
2024
MacroGenics (United States)
2011-2023
Singapore National Eye Center
2022-2023
Arsenal Biosciences (United States)
2023
Cornell University
2023
Singapore Eye Research Institute
2020-2022
Brown University
2022
Emory University
2021
Tebotelimab, a bispecific PD-1×LAG-3 DART molecule that blocks both PD-1 and LAG-3, was investigated for clinical safety activity in phase 1 dose-escalation cohort-expansion trial patients with solid tumors or hematologic malignancies disease progression on previous treatment. Primary endpoints were maximum tolerated dose of tebotelimab when administered as single agent (n = 269) combination the anti-HER2 antibody margetuximab 84). Secondary included anti-tumor activity. In advanced cancer...
Retifanlimab is a humanized, hinge-stabilized immunoglobulin G4κ monoclonal antibody against human programmed cell death protein 1 (PD-1). This first-in-human, phase I study assessed the safety and efficacy of retifanlimab in patients with advanced solid tumors identified optimal dosing.
The sclera plays an important role in the structural integrity of eye. However, as myopia progresses, elongation eyeball exerts stretching forces on posterior sclera, which typically happens conjunction with scleral remodeling that causes rigidity loss. These biomechanical alterations can cause localized deformation and vision impairment. Therefore, monitoring is clinically for management risk assessment myopia. In this study, we propose fundus pulsation optical coherence elastography...
Combination immunotherapy with antibodies directed against PD-1 and CTLA-4 shows improved clinical benefit across cancer indications compared to single agents, albeit increased toxicity. Leveraging the observation that are co-expressed by tumor-infiltrating lymphocytes, an investigational x bispecific DART molecule, MGD019, is engineered maximize checkpoint blockade in tumor microenvironment via enhanced a PD-1-binding-dependent manner. In vitro, MGD019 mediates combinatorial of CTLA-4,...
See also: Commentaire de travail G. Triadafilopoulos et al., pp. 478Endoscopy 2008; 40(06): 545-545DOI: 10.1055/s-0032-1306841
Background: Local recurrence following definitive treatment for pancreatic adenocarcinoma is common and can be associated with significant morbidity mortality. Retreatment options these patients are limited. Proton beam reirradiation (PRT) may limit dose toxicity to previously irradiated normal tissues in without evidence of metastatic disease. Methods: Between 8/2010–2/2015, 15 isolated, locally-recurrent cancer were treated PRT. Acute was graded using CTC v 4.0 defined as occurring within...
Purpose: Myopic macular degeneration (MMD) can cause irreversible vision loss. Thinner choroid is associated with increased MMD severity. This cross-sectional study analyzed choriocapillaris (CC) alterations in MMD. Methods: Axial length (AL), best-corrected visual acuity (BCVA), fundus photography, and swept-source optical coherence tomography angiography (SS-OCTA) were assessed controls high myopes (spherical equivalent ≤ −6 diopters). patients grade 2 (macular diffuse chorioretinal...
Purpose: To evaluate the agreement of a home vision screening test compared to standard in-office technician-measured Snellen visual acuity allow for remote and triaging patients. Patients Methods: In this prospective study, English-speaking patients with ophthalmology appointments from May August 2020 better than 20/125 were asked complete one week before their scheduled appointment. The was modified ETDRS chart displayed in PDF document that could be printed or viewed on monitor. primary...
Purpose: The purpose of this study was to develop an Asian polygenic risk score (PRS) predict high myopia (HM) in Chinese children the Singapore Cohort Risk factors for Myopia (SCORM) cohort. Methods: We included followed from 6 11 years old until teenage (12–18 old). Cycloplegic autorefraction, ultrasound biometry, Illumina HumanHap 550, or 550 Duo Beadarrays, demographics, and environmental data were obtained. PRS generated Consortium Refractive Error genomewide association (n = 542,934)...
Abstract Vascular endothelial (VE)-cadherin is a well-recognized cell marker. One of its interacting partners, the TGF-β receptor Alk1, essential in cells for adult skin vasculature remodeling during hair homeostasis. Using single-cell transcriptomics, lineage tracing and gene targeting mice, we characterize cellular molecular dynamics VE-cadherin + We describe dynamic changes specific to blood lymphatic vessels uncover an atypical population. The latter not predicted endovascular...
Human T cells are central to physiological immune homeostasis, which protects us from pathogens without collateral autoimmune inflammation. They also the main effectors in most current cancer immunotherapy strategies 1 . Several decades of work have aimed genetically reprogram for therapeutic purposes 2–5 , but as human resistant standard methods large DNA insertion these approaches relied on recombinant viral vectors, do not target transgenes specific genomic sites 6, 7 In addition, need...
ABSTRACT Virus-modified T cells are approved for cancer immunotherapy, but more versatile and precise genome modifications needed a wider range of adoptive cellular therapies 1–4 . We recently developed non-viral CRISPR–Cas9 system genomic site-specific integration large DNA sequences in primary human 5 Here, we report two key improvements efficiency viability an expanded variety clinically-relevant cell types. discovered that addition truncated Cas9 target (tCTS) at the ends homology...
Background: It is unclear whether post-operative errors after toric intraocular lens implantation would be more amenable to pre-operative correction with a fixed adjustment or ratio that scales the magnitude of astigmatism. Purpose: To investigate effect anterior corneal astigmatism orientation on outcomes in large population. Methods: A retrospective cohort study 625 patients undergoing refractive exchange through superior clear incision Oculentis M-Plus at an Optical Express, Inc. located...
Myopia affects 1.4 billion individuals worldwide. Notably, there is increasing evidence that choroidal thickness plays an important role in myopia and risk of developing myopia-related conditions. With the advancements artificial intelligence (AI), segmentation can now be automated, offering inherent advantages such as better repeatability, reduced grader variability, less reliance for manpower. Hence, we aimed to evaluate agreement between AI-automated manual segmented measurements...
Abstract Background We evaluated the fully human polyclonal antibody product SAB-185 in a phase 3 trial for COVID-19. Methods Nonhospitalized high-risk adults within 7 days of symptom onset were randomized 1:1 to open-label 3840 units/kg or casirivimab/imdevimab 1200 mg. Noninferiority comparison was undertaken pre-Omicron population (casirivimab/imdevimab expected be active) and superiority Omicron not active). Primary outcomes composite all-cause hospitalizations/deaths grade ≥3...
We explored viral and symptom rebound after COVID-19 amubarvimab/romlusevimab monoclonal antibody therapy vs placebo in the randomized ACTIV-2/A5401 trial. Participants underwent nasal SARS-CoV-2 PCR at study days 3, 7, 14, 28. Viral was defined as RNA ≥3 ≥0.5 log10 copies/mL increase from day 3 or hospitalization any moderate/severe for ≥2 initial improvement. There no difference (∼5%/arm) (analysis population n=713) among participants who initially improved (hazard ratio 0.95 (95% CI 0.52,...
Purpose: To report a case of Coccidioides immitis endophthalmitis with severe vision loss and return to excellent after aggressive intervention. Methods: Case report. Results: A 41-year-old man history solid organ transplantation who complained floaters decreased in the setting disseminated infection was found have presumed coccidioidal visual acuities 20/20 right eye 20/200 left eye. The patient managed intravenous amphotericin B, oral voriconazole, intravitreal injections B voriconazole...