A5067663921- Muon and positron interactions and applications
- Semiconductor materials and devices
- Corneal surgery and disorders
- Ocular Surface and Contact Lens
- Graphene research and applications
- Corneal Surgery and Treatments
- Semiconductor materials and interfaces
- Intraocular Surgery and Lenses
- Semiconductor Quantum Structures and Devices
- Ammonia Synthesis and Nitrogen Reduction
- Retinal and Optic Conditions
- Particle Detector Development and Performance
- Ocular Infections and Treatments
- Glaucoma and retinal disorders
- Ocular Diseases and Behçet’s Syndrome
- Electron and X-Ray Spectroscopy Techniques
- Advancements in Battery Materials
- Ophthalmology and Visual Impairment Studies
- Silicon Nanostructures and Photoluminescence
- Adhesion, Friction, and Surface Interactions
- Atomic and Molecular Physics
- Silicon and Solar Cell Technologies
- Silicon Carbide Semiconductor Technologies
- Quantum and electron transport phenomena
- Retinal Diseases and Treatments
University of California, Los Angeles
2005-2025
University of California, San Francisco
2024-2025
San Francisco Foundation
2025
Doheny Eye Institute
2020-2024
Atomic Weapons Establishment
2023
Creative Commons
2022
University of Toronto
2017-2020
Hospital for Sick Children
2017-2020
Moorfields Eye Hospital NHS Foundation Trust
2012-2019
University College London
2012-2019
The majority of Na+ channels in the heart are composed tetrodotoxin (TTX)-resistant (KD, 2-6 microm) Nav1.5 isoform; however, recently it has been shown that TTX-sensitive 1-10 nm) neuronal channel isoforms (Nav1.1, Nav1.3 and Nav1.6) also present functionally important myocytes ventricles sinoatrial (SA) node. In study, mouse SA node pacemaker cells, we investigated currents under physiological conditions expression cardiac isoforms. We identified two distinct current components, TTX...
Purpose.: To investigate the impact of diabetic macular ischemia (DMI) on visual acuity (VA), through analysis novel fluorescein angiography (FA) parameters. Methods.: Data were retrospectively collected over a 6-month period. DMI severity was graded using Early Treatment Diabetic Retinopathy Study (ETDRS) protocols. Custom software used to quantify areas foveal avascular zone (FAZ), and capillary nonperfusion papillomacular nerve fiber layer bundle, temporal macula, associations tested with...
PurposeIn previous studies of fungal keratitis (FK) from temperate countries, yeasts were the predominant isolates, with ocular surface disease (OSD) being leading risk factor. Since 2005–2006 outbreak contact lens (CL)-associated Fusarium keratitis, there may have been a rise in CL-associated filamentary FK United Kingdom. This retrospective case series investigated patterns 2007 to 2014. We compared these 1994–2006 data same hospital.DesignRetrospective observational study.MethodsAll cases...
Antibody drug conjugates (ADCs) are an emerging class of treatments designed to improve efficacy and decrease toxicity compared with other systemic therapies through the selective delivery cytotoxic agents tumor cells. Datopotamab deruxtecan (Dato-DXd) is a novel ADC comprising topoisomerase I inhibitor payload monoclonal antibody directed trophoblast cell-surface antigen 2 (TROP2), protein that broadly expressed in several types solid tumors. Dato-DXd being investigated across multiple...
Abdul Fattah, Maamoun MD; Mireskandari, Kamiar FRCOphth, PhD; Fung, Simon S. M. MD, MA(Oxon), FRCOphth; Woo, Jyh Haur Ali, Asim FRCSC Author Information
We have examined sino-atrial node (SAN) function in hearts from adult mice with heterozygous targeted disruption of the Scn5a gene to clarify role Scn5a-encoded cardiac Na+ channels normal SAN and mechanism(s) by which reduced channel might cause sinus dysfunction. Scn5a+/- showed depressed heart rates occasional (SA) block. Their isolated peripheral pacemaker cells a expression slowed intrinsic rates. Wild-type (WT) preparations exhibited similar activation patterns but significantly slower...
We described the optical coherence tomography (OCT) features of diabetic macular ischemia (DMI), and correlate these findings with visual acuity (VA).Clinical imaging data were collected from 100 patients type 2 diabetes. Qualitative grading DMI severity was determined according to criteria defined by Early Treatment Diabetic Retinopathy Study. Quantitative analysis foveal avascular zone (FAZ), OCT images performed using custom software.In all eyes, outer retina thicker in eyes (167.4 ± 18.5...
Purpose: To document the presence and location of new sensory nerve fibers after corneal neurotization using in vivo confocal microscopy (IVCM) 2 patients with neurotrophic keratopathy (NK). Methods: Two unilateral advanced NK received to surgically reinnervate cornea. IVCM was used identify subbasal reinnervation. In 1 patient (case 1), performed before neurotization; second 2), transplantation. Results: case 1, who had hand motion visual acuity due NK-associated perforation that...
<h3>Aim</h3> To estimate current clinical practice for frequency of visual field (VF) monitoring in glaucoma England. <h3>Methods</h3> A cross-sectional review all patients with chronic open angle (COAG) attending specialist clinics at six hospitals England was performed. The number VF tests undertaken prior to the study date and during first 2 years since diagnosis were recorded compared European Glaucoma Society (EGS) guidelines newly-diagnosed patients. Clinician-requested intervals from...
Aim To report clinical outcomes and evidence of corneal innervation in patients with neurotrophic keratopathy (NK) treated minimally invasive neurotisation (MICN) using a sural nerve graft donor sensory nerves from the face. Methods Patients undergoing MICN at The Hospital for Sick Children, Toronto, Canada were prospectively recruited. Data on central sensation (CCS, measured Cochet-Bonnet aesthesiometer), best-corrected visual acuity (BCVA) epithelial integrity collected. In four who...
The measurement of photoconductivity in samples semi-insulating n-type Fe-doped InP are reported. Optical transitions interpreted as between Fe3+, Fe2+ and Fe+ ions the conduction valence bands, well an internal transition level. relative strengths observed found to depend strongly upon doping due change concentration different ion species present. A level scheme energy acceptors at 6K (300K) is deduced consist ground state 0.64 eV (0.66 eV) below Gamma -point minimum with excited 0.351...
Purpose.: To describe novel segmentation protocols for choroidal layers, Sattler's medium and Haller's large vessel using enhanced depth imaging optical coherence tomography (EDI-OCT), to examine the repeatability reproducibility of these measurements in eyes with diabetic retinopathy. Methods.: Fifty-one patients Type 2 diabetes mellitus were imaged custom EDI scanning protocols. Detailed was performed quantify retina, choroid, large, layers total macular circle (TMC) foveal central...
This case report highlights a of lens subluxation in Marfan syndrome diagnosed using swept-source anterior-segment optical coherence tomography (OCT).
Purpose . To report 7 cases of intraocular lens (IOL) opacification following treatment postoperative anterior chamber fibrin with recombinant tissue plasminogen activator (rtPA) after cataract surgery. Methods Retrospective case series eyes in patients who developed IOL receiving rtPA for inflammatory membrane formation resulting from phacoemulsification Three explanted IOLs were investigated light microscopy, histochemical analysis, scanning electron and X-ray spectrometry. Results All...
PURPOSETo investigate whether neurotrophic keratopathy is present in limbal stem cell deficiency (LSCD), by measuring corneal sensation and characterizing subbasal nerve plexus.DESIGNProspective, cross-sectional, case-control comparative study.METHODSA total of 46 eyes with LSCD 14 normal were recruited from 2019 to 2022. Corneal was measured using a Cochet–Bonnet esthesiometer, plexus imaged vivo confocal microscopy (IVCM) at the central cornea 4 regions. Subbasal density (SND, number...
Strong visible electroluminescence (EL) has been observed from a 30 nm silicon nitride thin film multiply implanted with Si ions and annealed at 1100 °C. The EL intensity shows linear relationship the current transport in lower voltages, but departure quenching is higher voltages. spectra show two primary bands including predominant violet band ∼3.0 eV (415 nm) strong green-yellow ∼2.2 (560 nm). Two weak ultraviolet ∼3.8 near infrared ∼1.45 emerge high evolution of each voltage examined....