A5076718307- Cephalopods and Marine Biology
- Genetics and Neurodevelopmental Disorders
- Chromatin Remodeling and Cancer
- Neuroendocrine regulation and behavior
- Thyroid Disorders and Treatments
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Congenital heart defects research
- Memory and Neural Mechanisms
- Electromagnetic Fields and Biological Effects
- Glioma Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Schizophrenia research and treatment
- Mitochondrial Function and Pathology
- Metabolism, Diabetes, and Cancer
- Inhalation and Respiratory Drug Delivery
- Neurobiology and Insect Physiology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Asthma and respiratory diseases
- Human-Animal Interaction Studies
- Anesthesia and Neurotoxicity Research
- Chemical Reactions and Isotopes
- Memory Processes and Influences
- Cerebrospinal fluid and hydrocephalus
- Axon Guidance and Neuronal Signaling
Centre National de la Recherche Scientifique
2008-2025
Institut des Neurosciences Paris-Saclay
2018-2025
Université Paris-Saclay
2019-2025
CEA Paris-Saclay
2023
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2023
Université Paris-Sud
2006-2019
Université de Montréal
2018
Roche (Switzerland)
2012
Laboratoire de Psychologie et NeuroCognition
2008
Canadian Nautical Research Society
2007-2008
The different gene members of the Egr family transcriptional regulators have often been considered to related functions in brain, based on their co-expression many cell-types and structures, relatively high homology translated proteins ability bind same consensus DNA binding sequence. Recent research, however, suggest this might not be case. In review, we focus current understanding functional roles learning memory. We briefly outline evidence from mutant mice that Egr1 is required...
The multifactorial causes impacting the risk of developing sporadic forms Alzheimer's disease (AD) remain to date poorly understood. Epidemiologic studies in humans and research rodents have suggested that hypothyroidism could participate etiology AD. Recently, we reported adult-onset rats favors β-amyloid peptide production hippocampus. Here, using same model with antithyroid molecule propythiouracyl (PTU), further explored AD-related features, dysfunctional cell-signaling mechanisms...
The fifth generation (5G) of mobile communications promotes human exposure to electromagnetic fields exploiting the 3.5 GHz frequency band. We analyzed behaviors, cognitive functions, and gene expression in mice submitted asymmetrical head a 5G-modulated signal. exposures were applied for 1 h daily, 5 days per week over six-week period, at specific absorption rate (SAR) averaging 0.19 W/kg brain. Locomotor activities an open field, object location, recognition memories assessed repeatedly...
ORIGINAL RESEARCH article Front. Behav. Neurosci., 30 December 2007Sec. Learning and Memory Volume 1 - 2007 | https://doi.org/10.3389/neuro.08.006.2007
The idea that an already consolidated memory can become destabilised after recall and requires a process of reconsolidation to maintain it for subsequent use has gained much credence over the past decade. Experimental studies in rodents have shown pharmacological, genetic or injurious manipulation at time reactivation disrupt memory. Despite force experimental data showing this phenomenon, number questions remained unanswered no consensus emerged as conditions under which be disrupted...
Abstract Food preferences were investigated in cuttlefish during the first 3 months' posthatching, using choice tests between crabs, shrimps, and young fish. The results showed that without previous feeding experience, preferred shrimps on Day 3. This suggests an innate food preference; however, it was possible to induce a preference for originally nonpreferred prey item 3‐day‐old naïve cuttlefish, demonstrating flexibility of this initial behavioral response individual experience. learning...
This study investigates effects of the environment on maturation body patterns in cuttlefish (Sepia officinalis). Cuttlefish were reared either individually a uniform background, which authors have termed uniform-solitary conditions (Group A), or grouped variegated backgrounds, varied-social B). At Days 1, 15, 30, and 60, juveniles placed perceptually different testing conditions, small, stones pale gray background. During development both from Group B concealed themselves differently those...
The link between mutations associated with intellectual disability (ID) and the mechanisms underlying cognitive dysfunctions remains largely unknown. Here, we focused on PAK3, a serine/threonine kinase whose gene cause X-linked ID. We generated new mutant mouse model bearing missense R67C mutation of Pak3 (Pak3-R67C), known to moderate severe ID in humans without other clinical signs investigated hippocampal-dependent memory adult hippocampal neurogenesis. Adult male Pak3-R67C mice exhibited...
Adult-onset hypothyroidism is associated with learning and cognitive dysfunctions, which may be related to alterations in synaptic plasticity. Local reduced levels of thyroid hormones (THs) impair glia morphology activity, promote the increase pro-inflammatory cytokine mainly hippocampus. Given that neuroinflammation induces memory impairments, hypothyroidism-related dysfunction participate brain disorders. Thus, we investigated mechanisms linking neuroinflammation, from a protective...
Intellectual disability (ID) is a neurodevelopmental disorder associated with impaired cognitive and adaptive behaviors represents major medical issue. Although ID-patients develop behavioral problems are diagnosed during childhood, most studies in rodent models have been conducted adulthood, missing precocious phenotypes expressed this critical time-window characterized by intense brain plasticity. Here, we selectively assessed postnatal ontogenesis of processes, as well development the...
The cognitive consequences of postnatal brain exposure to ionizing radiation (IR) at low moderate doses in the adult are not fully established. Because advent pediatric computed tomography scans used for head exploration, improving our knowledge these effects represents a major scientific challenge. To evaluate how IR may affect developing brain, models either whole (WB) or targeted dorsal dentate gyrus (DDG) irradiation C57Bl/6J ten-day-old male mice were previously developed. Here, using...
High static magnetic (B0) fields are known to induce a transient disturbance of the inner ear. Recently study demonstrated long-term behavioural effects in mice chronically exposed B0 field 16.4T. In current study, underwent chronic exposure at 11.7T or 17.2T and longitudinally performed tests over study. An auditory brainstem response (ABR) test was end full period assess ear properties. Despite observed immediately after exposure, no short-term alteration detected with ABR tests.
4-cresol (4-methylphenol, p-cresol) is a xenobiotic substance negatively correlated with type 2 diabetes and associated health improvement in preclinical models of diabetes. We aimed at refining our understanding the physiological role this metabolite identifying potential signalling mechanisms. Functional studies revealed that does not deteriorate insulin sensitivity human primary adipocytes exhibits an additive effect to on mouse C2C12 myoblasts. Experiments isolated islets showed...