Summary objective Mild thyroid failure is associated with an increased risk for development of atherosclerosis, but whether subclinical hypothyroidism related to cardiovascular disease controversial. The purpose the present study was examine a possible association between and disease. design Cross‐sectional general population. patients Twelve hundred twelve subjects, men women, 20 69 years old without not treated drugs interfering function or analysis TSH were included. measurements Clinical...

Background Treatment of hypothyroidism with 3,5,3′-triiodothyronine (T 3 ) is controversial. A recent meta-analysis concludes that no evidence present in favour using T . However, the analysis included a mixture different patient groups and dose-regimens. Objective To compare effect combination therapy thyroxine 4 versus monotherapy patients on stable substitution. Study design Double-blind, randomised cross-over. Fifty micrograms usual dose was replaced either 20 μg or 50 for 12 weeks,...

Introduction. The aim of this study was to estimate the significance TSH, thyroid peroxidase antibody (TPOAb), and mild (subclinical) hypothyroidism in women from Danish General Suburban Population Study (GESUS) on number children born, pregnancies, spontaneous abortions. Methods. Retrospective cross sectional 11254 participating GESUS. Data included biochemical measurements a self-administrated questionnaire. Results. 6.7% had 9.4% prevalent hypothyroidism. In with TPOAb significantly...

Background: The Danish General Suburban Population Study (GESUS), the objective of which is to facilitate epidemiological and genetic research, has included Major Depression Inventory (MDI) WHO-Five Well-Being Index (WHO-5) among medical health questionnaires. We were thus in a position compare 2-week prevalence ICD-10 depression period from 2010 2012 with our previous general population study 2003, MDI was also included. Aims: aim analysis not only evaluate point but describe...

Background: The association between subclinical hypothyroidism (SCH), with and without raised thyroid peroxidase antibodies (anti-TPO), well-being or depression is still controversial, in spite of many studies on the topic. Aims: In this large general population study 8214 individuals, we aim to clarify significance elevated levels anti-TPO as a marker poor euthyroid individuals SCH. Methods: participants from Danish General Suburban Population Study (GESUS), serum stimulating hormone (TSH),...

Diabetic nephropathy is one of the leading causes end-stage renal disease. We examined whether ACE inhibitor treatment may have a nephroprotective effect in normotensive insulin-dependent diabetic patients without microalbuminuria and with normal glomerular filtration rate (GFR), any was associated genotype. In prospective double-blind randomized study, type 1 diabetes mellitus serum creatinine no were treated either placebo or perindopril, an inhibitor. Urine albumine/creatinine ratio...

L-thyroxine (T4), L-triiodothyronine (T3) and 3,5-di-iodothyronine (T2) rapidly (within 30 min) stimulated oxygen consumption in human mononuclear blood cells, whereas the D isomers of T4 T3 Triac had no stimulatory effect. Oxygen was by same magnitude equimolar concentrations (5-500 nmol/l) L-T4, L-T3 3,5-T2 reaching a plateau at 100 nmol/l 0.025 umol/mg DNA × h. The effects T3, but not T2 were inhibited PTU.

Recent studies concerning the association between extraocular muscle (EOM) enlargement in thyroid-associated ophthalmopathy (TAO) and immunological clinical activity have not been conclusive, probably due to a lack of uniform imaging methods (ultrasonography, computer tomography [CT] or magnetic resonance [MRI]) difficulties determination EOM volume. The aim present study was examine significance as established by MRI-based volume determination, with reference proptosis presence...

It is well documented that overt hypothyroidism associated with adverse pregnancy outcomes, but studies of subclinical have demonstrated conflicting results.Thyroid hormones are known to regulate mitochondrial function, and the aim this study was examine possible relationship dysfunction outcomes in pregnant women.Women their third trimester (n = 113) who did not receive thyroid medication were included cross-sectional study. All participants interviewed, status determined. had...

The aim of the present study was to examine mitochondrial function in cells from persons with subclinical hypothyroidism and euthyroid controls. participating were examined clinically had basal oxygen consumption (VO2) determined. concentrations thyroid hormones thyrotropine stimulating hormone determined, isolated mononuclear blood by enzymatic methods [citrate synthase activity (CS)] flow cytometry (mitochondrial membrane potential TMRM fluorescence mass MTG fluorescence). ratio T4/T3...

Abstract Aim: Although obesity and weight gain generally are anticipated to be caused by an imbalance between energy intake expenditure, the significance of thyroid hormones (TH) remains unclear. Examination mitochondrial function may reflect intracellular hormone effect elucidate whether a lower metabolic rate is present. Methods: In group 34 obese adolescents (age <16 years body mass index above age‐related 95th percentile), age‐ gender‐matched 32 lean adolescent, stimulating (TSH)...

Background: The first phase of the Danish General Suburban Population Study (GESUS) including 8214 individuals was an attempt to evaluate association between subclinical hypothyroidism without or with elevated peroxidase antibodies and depression. No such found. In second phase, 14,787 individuals, we have focused on suppressed TSH (thyroid-stimulating hormone) Aims: To what extent is associated Methods: total scores Major Depression Inventory (MDI) were used depression, both by its score...

A recent randomized controlled trial suggests that hypothyroid subjects may find levothyroxine (l-T4) and levotriiodothyronine combination therapy to be superior l-T4 monotherapy in terms of quality life, suggesting the brain registered increased T3 availability during therapy.Peripheral tissue might also stimulated T4/T3 compared with T4 monotherapy.Serum levels sex hormone-binding globulin (SHBG), pro-collagen-1-N-terminal peptide (PINP), N-terminal pro-brain natriuretic (NT-proBNP)...

Purpose: To examine the frequency and causes of visual impairment (VI) in a select population Danish adults.Methods: A total 3843 adults aged 20–94 years from General Suburban Population Study (GESUS) were included population-based, cross-sectional ophthalmological study, Rural Eye (DRES). All DRES participants received comprehensive general health examination preceding their eye examination, including measurement best-corrected acuity (BCVA) for each eye, bilateral 45° retinal fundus...

The specific nuclear-binding of T3 (NBT3) in mononuclear blood cells, and the concentrations TSH, thyroid hormones, binding proteins were measured after overnight fasting 12 obese 14 non-obese women, none subjects taking any medicine. TSH free plus bound-T3 (TT3) significantly higher (p less than 0.05), T4 did not differ. NBT3 was lower women; maximal capacity (MBC) 34.5 +/- 11.6 fmol/mg DNA 50.0 0.02). affinities We have previously shown that increasing within physiological range...

Nuclear binding of thyroxine (T4) and triiodothyronine (T3) in mononuclear blood cells was investigated 12 young (age 16-30 years) healthy subjects (group A), middle-aged 31-60 B) elderly (61-90 subjects. Serum free T3 depressed group C as compared to the younger age groups, whereas serum T4 TSH did not differ between groups. Maximal specific nuclear capacity for both decreased with increasing age, A: 1.2 fmol T4/100 micrograms DNA, B: C: 0.7 DNA; 1.7 T3/100 1.0 0.9 DNA. The equilibrium...

Abstract. Serum free T 4 , 3 TSH and maximal nuclear binding capacity for in mononuclear blood cells were measured 12 control women, normal pregnant women the first third trimester. decreased late pregnancy compared to serum : 9.1 pmol/l (mean) vs 12.9 (mean); 4.0 6.2 (mean), without any change levels: 2.2 mU/l 1.8 (mean). Concomitantly, both increased, 2.7 fmol /100 μg DNA DNA; 2.8 2.0 DNA. These data, obtained from healthy during a are compatible with mild compensated hypothyroidism. We...

Bonnema SJ, Møller J, Marving Kvetny J (Departments of Internal Medicine and Clinical Physiology Nuclear Medicine, Esbjerg Centralsygehus, Esbjerg, Denmark). Sarcoidosis causes abnormal seasonal variation in 1,25‐dihydroxy‐cholecalciferol. Intern Med 1996; 239 : 393–98. Objectives. The spontaneous variations the calcium regulating hormones 1,25‐dihydroxy‐cholecalciferol (1,25‐DHCC) parathyroid hormone (PTH) were investigated patients with sarcoidosis. Design. Controlled, prospective...

Mitochondrial function may be impaired in a number of diseases including metabolic syndrome, cardiovascular disease and endocrine disorders. Therefore it is important to able measure mitochondrial human cells.The aim the present study was evaluate method derived cells, which also would reflect regulation by thyroid hormones.The MDA-MB-231 cell line (a breast cancer line) incubated with bioactive iodothyronines (T(4), 3'-3, 5-T(3), 3, 5-T(2)) 50 nmol/l for 3 h. membrane potentials (MMP) were...

Background: The significance of perturbations thyroid-stimulating hormone (TSH) and thyroid hormones within the laboratory reference ranges after hemithyroidectomy is unknown. Our aim was to examine changes in TSH for benign euthyroid goiter, focusing on tissue response by examining mitochondrial membrane potential (MMP) peripheral blood mononuclear cells (PBMCs) basal oxygen consumption (V˙<smlcap>O</smlcap>₂). Materials Methods: In a prospective study 28 patients controls, we...

A series of 597 consecutive patients with acute myocardial infarction (AMI) have been screened for diabetes mellitus (DM). Six per cent the had DM, which is exactly frequency DM in an age-matched population. This finding corresponds results other investigators, indicating that treated diabetics do not increased risk AMI. Diabetics suffering from AMI mortality, nor oral antidiabetics a higher mortality than those insulin.

Objective. Although it is well established that maternal thyroid disease and increased levels of thyrotropin receptor antibodies (TRab) during pregnancy are associated with a number complications, the significance peroxidase (TPOab) alone matter for discussion? The aim present study was to examine whether transplacental passage TPOab from women autoimmune (AITD) interferes function in neonate.Methods. Pregnant AITD (raised TPOab) their neonates were monitored regard variations hormones,...