A5100388406- Finite Group Theory Research
- Coding theory and cryptography
- graph theory and CDMA systems
- Medical Imaging Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Geometric and Algebraic Topology
- Radiopharmaceutical Chemistry and Applications
- Cooperative Communication and Network Coding
- Advanced Topics in Algebra
- Advanced Algebra and Geometry
- Rings, Modules, and Algebras
- Nanoplatforms for cancer theranostics
- Peptidase Inhibition and Analysis
- Quasicrystal Structures and Properties
- Estrogen and related hormone effects
- Antimicrobial Resistance in Staphylococcus
- Advanced Authentication Protocols Security
- Neurogenesis and neuroplasticity mechanisms
- 14-3-3 protein interactions
- Cancer, Hypoxia, and Metabolism
- MRI in cancer diagnosis
- Financial Markets and Investment Strategies
- Cytokine Signaling Pathways and Interactions
- Limits and Structures in Graph Theory
Shenyang Pharmaceutical University
2017
Sun Yat-sen University
2002-2016
Guangxi University
2010-2013
Guangdong University of Technology
2013
Case Western Reserve University
2011-2012
Case Comprehensive Cancer Center
2009-2011
University Hospitals Cleveland Medical Center
2011
Guangdong University of Education
2010
Lingnan University
2010
Shandong Provincial Hospital
2009
Existing antibody-drug conjugate (ADC) linkers, whether cleavable or non-cleavable, are designed to release highly toxic payloads payload derivatives upon internalisation of the ADCs into cells. However, clinical studies have shown that only <1 % dosed accumulate in tumour The remaining >99 nonspecifically distributed healthy tissue cells, thus inevitably leading off-target toxicity. Herein, we describe an intelligent tumour-specific linker strategy address these limitations. A is...
We study the detailed structure of a finite group under assumption that all minimal subgroups generalized Fitting subgroup some normal $G$ are well-suited in $G$.
Myelination is one of the fundamental biological processes in development vertebrate nervous system. Disturbance myelination found to be associated with progression many neurological diseases such as multiple sclerosis. Tremendous efforts have been made develop novel therapeutic agents that prevent demyelination and/or promote remyelination. These need accompanied by imaging tools permit direct quantification vivo . In this work, we describe a near-infrared fluorescence technique capable...
Antibody-drug conjugates (ADCs), designed to selectively deliver cytotoxic agents antigen-bearing cells, are poised become an important class of cancer therapeutics. Human epithelial growth factor receptor (HER2) is considered effective target for treatment, and a HER2-targeting ADC has shown promising results. Most ADCs undergoing clinical evaluation contain linkers that have lysosomal protease-cleavable dipeptide, which the most common valine-citrulline (VC). However, valine-alanine (VA),...
Antibody-drug conjugate (ADC) is a novel efficient drug delivery system that has been successfully used in clinical practice, and it become research hotspot the anti-tumor field. Acid-cleavable linkers were first ADCs, but their structural variety (e.g., hydrazone carbonate) still limited, stability usually insufficient. Designing acid-cleavable for conjugation of popular cytotoxin monomethyl auristatin E (MMAE) always significant topic. In this paper, we generate novel, silyl ether-based...
Monomethyl auristatin E (MMAE) is the most popular and widely used cytotoxin in development of antibody-drug conjugates (ADCs). However, current MMAE-based ADCs are all constructed using cleavable linkers, this design concept still has insurmountable drawbacks. Their potential instabilities lipophilic MMAE-induced “bystander effect” inevitably increase toxicity to normal tissues. Herein, we overturn previous negative views with non-cleavable linkers propose ionized L-Cysteine...
Maleimides are typically applicable for coupling with reactive thiol moieties of antibodies in antibody–drug conjugates (ADCs) via the thiol-Michael click chemistry. Even so, thiosuccinimide group produced ADCs is unstable under physiological conditions, which a unresolved issue ADC industry that can cause serious off-target toxicity. Committed to solving stability defects traditional thiosuccinimide-containing ADCs, we explored series linkers based on ring-opening hydrolysates...
Let G be a finite group, E normal subgroup of and p fixed prime. We say that is p-hypercyclically embedded in if every p-G-chief factor cyclic. A H said to satisfy Π-property |G/K:NG/K((H∩L)K/K)| π((H∩L)K/K)-number for any chief L/K G; Π-normal has subnormal supplement T such H∩T⩽I⩽H some I satisfying G. In this paper, we prove only classes p-subgroups are Many recent results extended.
We are developing a methodology for the noninvasive imaging of glucose transport in vivo with PET and <sup>18</sup>F-labeled 6-fluoro-6-deoxy-d-glucose (<sup>18</sup>F-6FDG), tracer that is transported but not phosphorylated. To validate method, we evaluated biodistribution <sup>18</sup>F-6FDG to test whether it consistent known properties transport, particularly regard insulin stimulation transport. <b>Methods:</b> Under clamp conditions, rats were imaged at baseline under conditions...
Let G be a finite group. The question of how certain arithmetical conditions on the lengths conjugacy classes influence group structure has been studied by several authors. In this paper we study restrictions in which are not divisible p 2 for some prime p. We generalise and provide simplified proofs earlier results.
Carbon-11 radiolabeled amines constitute a very important class of radioligands that are widely used for positron emission tomography (PET) imaging. Radiolabeling is often achieved through radiomethylation using [11C]CH3I or [11C]CH3OTf under basic conditions in strictly anhydrous environment. Functional groups such as hydroxyl and carboxyl present the molecules normally base sensitive require protection deprotection, which substantially prolongs complicates radiolabeling process. Here we...
Let p be a fixed prime, G finite group and P Sylow p-subgroup of G. The main results this paper are as follows: (1) If gcd (p-1, |G|) = 1 2 does not divide |x | for any p′-element x prime power order, then is solvable p-nilpotent G/O (G) elementary abelian. (2) Suppose that p-solvable. p-1 element the p-length at most one. (3) χ(1) χ ∈ Irr (G), both p′-length 2.