A5100440917- Mosquito-borne diseases and control
- Viral Infections and Vectors
- HIV Research and Treatment
- COVID-19 epidemiological studies
- Hepatitis C virus research
- Viral Infections and Immunology Research
- Insect symbiosis and bacterial influences
- Asthma and respiratory diseases
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- CRISPR and Genetic Engineering
- Pneumocystis jirovecii pneumonia detection and treatment
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- Hepatitis B Virus Studies
- Virology and Viral Diseases
- Immune Cell Function and Interaction
- Cancer therapeutics and mechanisms
- Tuberculosis Research and Epidemiology
- HIV/AIDS drug development and treatment
- RNA Research and Splicing
- interferon and immune responses
- Viral Infections and Outbreaks Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
QIMR Berghofer Medical Research Institute
2012-2022
Hubei University of Medicine
2016
Taihe Hospital
2016
Chinese Academy of Medical Sciences & Peking Union Medical College
2015
Queensland University of Technology
2011-2014
Hudson Institute
2009
Burnet Institute
2004
The University of Queensland
2003-2004
Royal Children's Hospital
2003
Section:ChooseTop of pageAbstract <<MATERIALS AND METHODSRESULTSDISCUSSIONReferencesCITING ARTICLES
More than 100 arboviruses, almost all of which have an RNA genome, cause disease in humans. viruses are causing unprecedented health system challenges worldwide, many with little or no specific therapies vaccines available. Certain species mosquito can carry dengue virus (DENV), Zika (ZIKV) and yellow fever (YFV), where co-infection these has occurred. Here, we found that purified synthetic defective interfering particles (DIPs) derived from DENV type 2 (DENV-2) strongly suppressed...
Abstract Dengue virus (DENV) is spread from human to through the bite of female Aedes aegypti mosquito and leads about 100 million clinical infections yearly. Treatment options vaccine availability for DENV are limited. Defective interfering particles (DIPs) considered a promising antiviral approach but infectious contamination has limited their development. Here, DENV-derived DIP production cell line was developed that continuously produced DENV-free DIPs. The DIPs contained could deliver...
A self-modulating mechanism by the hepatitis C virus (HCV) core protein has been suggested to influence level of HCV replication, but current data on this subject are contradictory. We examined effect wild-type and mutated IRES- cap-dependent translation. The was shown inhibit both translation in an vitro system. This duplicated a dose-dependent manner with synthetic peptide representing amino acids 1-20 protein. able bind IRES as mobility shift assay. In contrast, derived from B (HBV) that...
To investigate the role of hepatitis C virus internal ribosome entry site (HCV IRES) domain IV in translation initiation and regulation, two chimeric IRES elements were constructed to contain reciprocal otherwise HCV classical swine fever elements. This permitted an examination control translation. A specific inhibitor IRES, vitamin B(12), was shown inhibit directed by all which contained from GB B elements, whereas core protein could only suppress wild-type IRES. Thus, mechanisms inhibition...
Previously we described a transdominant negative mutant of the HIV-1 Tat protein, termed Nullbasic, that downregulated steady state levels unspliced and singly spliced viral mRNA, an activity caused by inhibition Rev activity. Nullbasic also altered subcellular localizations other cellular proteins, including CRM1, B23 C23 in Rev-dependent manner, suggesting may disrupt function trafficking intervening with unidentified component nucleocytoplasmic transport complex. To seek possible...
Evaluation of: Marazzi I, Ho JSY, Kim J et al. Suppression of the antiviral response by an influenza histone mimic. Nature 483 (7390), 428–433 (2012). It is well known that to survive in cells, viruses have developed a variety means avoid host responses. Recently, reported novel evasion tactic contributed NS1 virus H3N2. In contrast other subtypes such as H1N1 or H5N1, H3N2 contains unique amino acid sequence ARSK at C-terminus NS1, which chemically similar functional domain ARTK N-terminus...