A5069489353- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Biological Evaluation
- Synthesis of Organic Compounds
- Click Chemistry and Applications
- Chemical Reaction Mechanisms
- Synthesis and biological activity
- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Synthesis and Reactions of Organic Compounds
- Fluorine in Organic Chemistry
- Synthesis and Reactivity of Heterocycles
- Radical Photochemical Reactions
- Oxidative Organic Chemistry Reactions
- Catalytic Cross-Coupling Reactions
- Chemical Synthesis and Reactions
- Quinazolinone synthesis and applications
- Synthesis of Indole Derivatives
- DNA and Nucleic Acid Chemistry
- HIV/AIDS drug development and treatment
- Biochemical and Molecular Research
- Fungal Plant Pathogen Control
- Plant chemical constituents analysis
- Luminescence and Fluorescent Materials
Ural Federal University
2014-2024
Institute of Organic Synthesis
2015-2023
Ural Branch of the Russian Academy of Sciences
2019-2023
Russian Academy of Sciences
2022
Institute of Chemical Engineering
2020
Wuhan University of Technology
2020
Hunan Institute of Science and Technology
2020
Indian Institute of Chemical Technology
2020
Technion – Israel Institute of Technology
2020
Stockholm University
2020
A green protocol has been developed for the synthesis of simple coumarins and linear pyrano[2,3- f ] [3,2- ]indoles by reaction phenol derivatives with β-ketoesters under ball milling at ambient temperature in presence methanesulfonic acid.
The selectively (15)N labeled azido-1,2,4-triazine 2*A and azidopyrimidine 4*A were synthesized by treating hydrazinoazines with (15)N-labeled nitrous acid. compounds studied (1)H, (13)C, NMR spectroscopy in DMSO, TFA, DMSO/TFA solutions, where the azide-tetrazole equilibrium could lead to formation of two tetrazoles (T, T') one azide (A) isomer for each compound. incorporation label led appearance long-range (1)H-(15)N coupling constants (J(HN)), which can be measured easily using...
Abstract Phenol derivatives are widespread as important building blocks in various pharmaceuticals, agrochemicals and materials. Modern economy requires development of “green” methodologies that improve the efficiency their use reduction waste. One such method is C−H/C−H cross‐coupling, also known cross‐dehydrogenative coupling reaction. In this review article, we have summarised cross‐coupling reactions phenols with five‐ six‐membered heterocyclic compounds, systemised methods activation...
Abstract An operationally facile and high yielding one‐pot protocol has been developed for the preparation of pyridines appended with pyrazole via NH linker. This includes S N ipso /aza‐Diels‐Alder reactions in up to 54 % yields starting from 1,2,4‐triazine precursors. All synthesized compounds have evaluated their silico activity against JAK1, SYK, FAK1 kinases. The most promising compound was tested vitro using A‐172, Hs578T, HepG2 cancer cell lines exhibited considerable cytotoxicity IC...
A transition metal-free process has been reported for 1,2-dithiocyanation of alkynes in the presence sodium persulfate and potassium thiocyanate reagent combination a short reaction time under ambient air. Styrene derivatives are equally applicable same conditions. Monothiocyanated vinyl were also synthesized from 2-ethynylpyridine dimethyl acetylene dicarboxylate. The proceeds by radical/polar pathway as evidenced our experiments literature. After removal solvent mixture evaporation, crude...
A new method for the direct metal-free C–H functionalization of electron-deficient triazines with fragments naturally occurring and synthetic 5,7-dihydroxycoumarins is reported. It has been found that reaction proceeds under mild conditions, showing a high chemo- regioselectivity.
The C-N coupling of 1,2,4-triazolo[1,5-a]pyrimidin-7-ones with 1-adamantanol/1-bromoadamantane leads to 1,2,4-triazolo[4,3-a]pyrimidinium-5-olates, which are represented as mesomeric betaines (MBs). formation MBs involves not only N-alkylation heterocyclic framework but also the rearrangement leading a change in type fusion between pyrimidine and 1,2,4-triazole fragments. structures obtained products were confirmed by X-ray analysis measurements 13 C-13 C (JCC ) constants 1D NMR spectra...
A total of 21 novel xanthone and acridone derivatives were synthesized using the reactions 1,2,4-triazine with 1-hydroxy-3-methoxy-10-methylacridone, 1,3-dimethoxy-, 1,3-dihydroxanthone, followed by optional dihydrotiazine ring aromatization. The compounds evaluated for their anticancer activity against colorectal cancer HCT116, glioblastoma A-172, breast Hs578T, human embryonic kidney HEK-293 tumor cell lines. Five (7a, 7e, 9e, 14a, 14b) displayed good in vitro antiproliferative activities...
A new synthetic protocol for nucleophilic substitution of hydrogen in quinoxalones and pteridinones by the action 5,7-dihydroxycoumarins related m-dihydroxybenzene compounds has been developed. The C–C coupling reaction proved to proceed smoothly under rather mild conditions, thus giving corresponding C–H functionalized products good yields. advantages this environmentally benign are high regio- chemoselectivity, an easy workup procedure. Direct incorporation coumarin moiety into pyrazine...
Abstract A simple and efficient method has been developed to synthesize 1‐oxa‐4‐aza‐spirooxazolines. The reaction was carried out at room temperature using rose bengal as an organic photoredox catalyst blue LED a light source. It observed that quinones underwent spiroannulation with vinyl azide on C−O double bond instead of C−C through which various corresponding 1‐oxa‐4‐aza‐spirooxazolines have synthesized in good excellent yields.
Determining the accurate chemical structures of synthesized compounds is essential for biomedical studies and computer-assisted drug design. The unequivocal determination N-adamantylation or N-arylation site(s) in nitrogen-rich heterocycles, characterized by a low density hydrogen atoms, using NMR methods at natural isotopic abundance difficult. In these compounds, heterocyclic moiety covalently attached to carbon atom substituent group that has no bound connection between two moieties...
Selectively 15N-labeled tetrazolo[1,5-b][1,2,4]triazines and tetrazolo[1,5-a]pyrimidines bearing one, two, or three 15N labels were synthesized. The synthesized compounds studied by 1H, 13C, NMR spectroscopy in DMSO TFA solutions, where the azide–tetrazole equilibrium can lead to formation of two tetrazole (T, T′) isomers one azide (A) isomer for each compound. Incorporation 15N-label(s) leads appearance 15N–15N coupling constants (JNN), which be easily measured via simple 1D spectra, even...
We have designed and synthesized a series of bioinspired pyrano[2,3-
Abstract A protocol for C–H/C–H cross-coupling reaction between 7-aminocoumarins and 1,2,4-triazines has been developed. The was carried out under heptafluorobutyric acid catalysis providing products with yield up to 91%. applicability scope of the proposed method demonstrated on 25 compounds containing different substituents both in triazine ring at nitrogen atom 7-aminocoumarins. study mechanism by EPR radical trapping suggests that radicals are involved this transformation.