A5004091595- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- Synthesis of heterocyclic compounds
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and Biological Evaluation
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Organoselenium and organotellurium chemistry
- Synthesis and Reactivity of Heterocycles
- Synthesis and Reactions of Organic Compounds
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Chemical Reaction Mechanisms
- Chemical synthesis and pharmacological studies
- Quinazolinone synthesis and applications
- Drug-Induced Hepatotoxicity and Protection
- Organic and Inorganic Chemical Reactions
- Organophosphorus compounds synthesis
- Sulfur Compounds in Biology
- Liver Disease Diagnosis and Treatment
- Click Chemistry and Applications
- Chemical Synthesis and Analysis
- Inflammatory mediators and NSAID effects
- Mosquito-borne diseases and control
- Sulfur-Based Synthesis Techniques
Luhansk State Medical University
2015-2024
Vladimir State University
2024
Peter the Great St. Petersburg Polytechnic University
2022-2024
Kuban State University
2015-2021
Virginia Commonwealth University
2021
National University
2019
Volodymyr Dahl East Ukrainian National University
2005-2014
N.D. Zelinsky Institute of Organic Chemistry
2006
Flaviviruses form a large family of enveloped viruses affecting millions people over the world. To date, no specific therapy was suggested for infected people, making treatment exclusively symptomatic. Several attempts were performed earlier design fusion inhibitors mosquito-borne flaviviruses, whereas tick-borne flaviviruses such had not been performed. We have constructed homology models envelope glycoproteins tick-transmitted with detergent binding pocket in open state. Molecular docking...
This Research Article describes the synthesis of an over 700-member library (8R/8S)-3-R-8-aryl-6-oxo-3,4,7,8-tetrahydro-2H,6H-pyrido[2,1-b][1,3,5]thiadiazin-9-carbonitriles by uncatalyzed Mannich-type reaction N-methylmorpholinium (4R/4S)-4-aryl-3-cyano-6-oxo-1,4,5,6-tetrahydropyridin-2-thiolates with a set primary amines and excessive HCHO. The scope limitations were studied. Starting thiolates obtained in yields 53-82% multicomponent aromatic aldehydes, cyanothioacetamide,...
Abstract Tick‐borne encephalitis virus (TBEV), a member of the genus Flavivirus , is leading cause arboviral neuroinfections in Europe. Only few classes nucleoside and non‐nucleoside inhibitors were investigated against TBEV reproduction. Paving way to previously unexplored areas anti‐TBEV chemical space, we assessed inhibition reproduction plaque reduction assay by various compounds derived from cyanothioacetamide cyanoselenoacetamide. Compounds seven classes, including...
Introduction . In the modern world people are exposed to influence of adverse psychological and physical factors, escalating in intensity. The search for new pharmacodynamic effects [1,3,5]-thiadiazine derivatives designated by significant biological activity these compounds is an essential issue. Aim To research adaptogenic tetrahydropyrido[2,1-b][1,3,5]thiadiazine using a modified Porsolt Forced Swim Test. Materials methods Four substances from group...
The Mannich-type reaction of N-methylmorpholinium 4-aryl-3-cyano-6-oxo-1,4,5,6-tetrahydropyridine-2-thiolates with 3-(1,3-benzodioxol-5-yl)-2-methylpropanal (ocean propanal) and p-toluidine afforded 7-aryl-2-(1,3-benzodioxol-5-ylmethyl)-2-methyl-3-[(4-methylphenyl)amino]-5-oxo-2,3,6,7-tetrahydro-5H-thiazolo[3,2-a]pyridine-8-carbonitriles in modest (25–46%) yields. structure the key compound was confirmed by X-ray crystal analysis.
Introduction: Our goal is to conduct an investigation of the analeptic activity tetrahydropyrido [2,1-b] [1, 3, 5] thiadiazine derivative group. Materials and Methods: Biological studies were carried out on 78 white pedigreed mature sexually transmitted rats both sexes weighing 230-270 g in autumn-winter period. The test substances administered intragastrically at a dose 5 mg/kg 1 hour prior induction anesthesia. Animals control group received thiopental sodium 70 mg/kg. As reference...