A5052142282- Synthesis and biological activity
- Synthesis of heterocyclic compounds
- Chemical Thermodynamics and Molecular Structure
- Synthesis and Reactivity of Heterocycles
- Analytical Chemistry and Chromatography
- Synthesis and Characterization of Heterocyclic Compounds
- Tribology and Wear Analysis
- Technical Engine Diagnostics and Monitoring
- Surface Treatment and Coatings
- Synthesis and Biological Evaluation
- Mechanical Systems and Engineering
- Molecular Spectroscopy and Structure
- Radioactive Decay and Measurement Techniques
- Scientific Measurement and Uncertainty Evaluation
- Chemical Synthesis and Analysis
- Transport and Logistics Innovations
- Asymmetric Synthesis and Catalysis
- Coal Combustion and Slurry Processing
- Pharmacological Receptor Mechanisms and Effects
- Phytochemistry and biological activities of Ficus species
- Ionic liquids properties and applications
- Chemical synthesis and pharmacological studies
- Polymer Science and Applications
- Industrial Engineering and Technologies
- Multicomponent Synthesis of Heterocycles
Luhansk State Medical University
2021-2024
Central Ukrainian National Technical University
2019-2020
Volodymyr Dahl East Ukrainian National University
2014-2019
D.I. Mendeleyev All-Russian Institute for Metrology
2017
N.D. Zelinsky Institute of Organic Chemistry
1991
Russian Academy of Sciences
1983
Competition in the field of logistics and individual transport services requires constant analysis chains their links. Given enables implementation new approaches to companies networks trade marketing offtake certain types goods. Industrial commercial enterprises have expand economic relations with other regions aim provide necessary sales volumes domestic market go beyond it. Integration country's economy free policy orientation greatly simplify task establishing between producers...
The paper reports an analysis into tribological efficiency of mating parts "polymeric-composite materials ‒ steel" is carried out. Improperly selected produce significant operating costs in terms tribology. Therefore, selecting the type polymeric-composite to be used structures nodes and machine a task related substantial improvement their technical level.The testing samples made from for relative abrasive resistance when mated with steel 45 has it possible establish that lowest value weight...
BACKGROUND: An urgent task in pharmacology is to identify highly effective drugs with analgesic and anti-inflammatory activity. Heterocyclic cyanothioacetamide compounds are of considerable interest. Most authors evaluate the results studies separate private indicators activity, their comprehensive criterion assessment insufficiently defined.
 AIM: Development a study activity establishment its generalized criteria for samples chemical medicinal products.
 MATERIALS AND METHODS:...
This key comparison aims to assess the core capabilities of participants in gas analysis. Such competences include, among others, prepare primary standard Mixtures (PSMs), perform necessary purity analysis on materials used mixture preparation, verification composition newly prepared PSMs against existing ones, and capability calibrating a mixture. According Strategy for Key Comparisons Gas Analysis Working Group, this is classified as track A comparison, which means that results can be...
Studies of the formation optimal composition Tribological additives to base oil have shown possibility improving characteristics tribosystem.It was revealed that this additive makes it possible form functional surface layers provide normal operating conditions for tribological conjugation parts.Based on optimization technical condition additives, values each its components are obtained.Optimization provided amount wear should tend a minimum, and maximum load loading weld maximum.Based...
The conducted studies of the formation rational composition a tribologically active additive to basic oil showed possibility improve characteristics tribosystems. It was revealed that this enables tribological properties ensure normal working conditions for operation mated parts tribosystem. Based on optimization technical condition additive, values each its components were obtained. Optimization carried out magnitude wear should be minimized, while critical load and welding maximized....
Background. In the majority of cases, contemporary pharmacological correction mainly focuses on most effective analgesia. Therefore, search for and research into new analgesic drugs are a priority in modern pharmacology. Objective — to establish level activity eight novel heterocyclic compounds 1,4-dihydropyridine derivatives synthesized classic test orofacial trigeminal pain animal experiments. Methods. An experimental preclinical randomized trial was carried out. The experiment conducted...
Introduction: It is revelant to solve the problem of anesthesia based on research new highly effective and safe medicines. Among modern studies, preparation heterocyclic compounds starting from cyanothioacetamide with analgesic anti-inflammatory activities considerable interest. Materials Methods: болевой синдром Results: shown that all studied 1,4-dihydropyridines condensed thieno[2,3-b]pyridines reveal activity varying degrees severity, values criterion Anat. Discussion: was found most...
Background . α-сyanothioacetamide derivatives are promising targets for the search effective and safe antinociceptive agents with antipyretic antiexudative activity. The aim To conduct in vivo experimental study of anti-inflammatory analgesic effects new thienopyridines 1,4-dihydropyridines derivatives. Materials methods synthesized cyanothioacetamide were subjected to virtual bioscreening using Swiss Target Prediction online service. 140 laboratory rats randomly distributed into intact...
Background . Over the past decades, scientific community is motivated on finding new anti-inflammatory agents with a safe and high-effective profile to manage pathology. Objectives A study of action novel compounds, 1,4-dihydropyridine derivatives, in classical formalin-induced paw oedema test white rats. Methods Originally synthesised derivatives were preliminarily subjected virtual screening using SwissTargetPrediction toolkit. White laboratory rats (130 animals) divided into control (formalin...
Nowadays the search of new high-efficiency and safe drugs for pharmacotherapy diseases accompanied by pain syndrome is an active area modern pharmacological research. 170 derivatives di- tetrahydropyridines synthesized on basis Chemex Research Laboratory, Vladimir Dahl Lugansk State University were exposed to virtual bioscreening using Swiss Target Prediction software. The paper describes screening studies in vivo 5 samples sulfur-containing (laboratory codes d02-138, as-262, f02-079,...
This article presents the report on COOMET supplementary comparison "Atmospheric air pollutants: CO in Nitrogen, 5 μmol/mol". Carbon monoxide (CO) is present atmosphere due to different natural and anthropogenic sources. a toxic gas concentrations higher than (3-5) μmol/mol it hazardous human health. Main text To reach main of this paper, click Final Report . Note that which appears Appendix B BIPM key database kcdb.bipm.org/ The final has been peer-reviewed approved for publication by CCQM,...
COOMET.QM-S3 is a supplementary comparison of primary standard gas mixtures—'Carbon monoxide in Nitrogen (3 μmol/mol)'. This bilateral between VNIIM and INMETRO it was conducted 2013. Carbon toxic concentrations higher than 3–5 μmol/mol hazardous to human health. Therefore, important for NMIs have the capability an accurate carbon measurements. has shown that mixtures nitrogen on level 3 μmol/mol, prepared Inmetro, do not agree—the pair-wise degree equivalence D (0.77%) appropriate expanded...
This article presents the report on COOMET key comparison COOMET.QM-K111, which is linking to appropriate CCQM comparison—CCQM-K111 'Propane in nitrogen 1000 μmol/mol'. CCQM-K111 was carried out 2014–2016 and it one of a series comparisons gas analysis area assessing core competences. Main text To reach main this paper, click Final Report . Note that appears Appendix B BIPM database kcdb.bipm.org/ The final has been peer-reviewed approved for publication by CCQM, according provisions CIPM...
Current experimental and theoretical methods of research jet elements used in agricultural means mechanization are considered the article. The work processes aerodynamic flows power have been researched on basis simulation modeling ANSYS Fluent software environment. Elements for application seeding systems sowing machines were developed as a result modeling. Dimensional, characteristics operation modes optimized elements. Application new produced provides improvement technical economic machines.